DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18476 and Zfp74

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_848471.2	Gene:	Zfp74 / 72723	MGIID:	107784	Length:	679	Species:	Mus musculus

Alignment Length:	857	Identity:	215/857 - (25%)
Similarity:	310/857 - (36%)	Gaps:	282/857 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 KLETEDEDC------------GE----------ND--------VTITCSELPEPDET----DMES 144
            |||.|:|.|            ||          .|        ||...||.||...:    :.:|
Mouse    59 KLEQEEEPCVVEREVLWRPCPGEILGIDEHQKIQDGQVFEGIVVTSEASECPEEFASTFFPNADS 123

  Fly   145 KKSVDPLTMIETVKLEMEPR----SVEKPAYDDPTSDFEDEDSLDNLPLYNRIQKWKTGRK---- 201
            ..|:..|...:.|...:||.    .|:.|.   |...||.:|::         |.:.|...
Mouse   124 IPSMHSLFECDGVGECLEPNFGDDDVQYPL---PEEQFEYDDAM---------QPFHTSSPHFVL 176

  Fly   202 SVYKCHDCPRSFKRFDFLKRHEMRVHKPETRLYDCSLCIRKFSRSEALEAHLKIHRNSKRSANIS 266
            :.:||:.|.:.|.:...|.|| :||| ...:||:|..|.:.||..|.|..|.|:|...:
Mouse   177 TPFKCNHCGKGFSQTLDLIRH-LRVH-TGGKLYECHQCGKGFSHKEKLINHHKLHSREQ------ 233

  Fly   267 EHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIADLRRHLEEH----PDIVSLCGRPNMEPHELA 327
                        |       .||..|...:.|:::|.||...|    |.:...||:
Mouse   234 ------------C-------YECSECGKTFIKMSNLIRHQRIHTGEKPYVCQECGK--------- 270

  Fly   328 ELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQSGYEMDLDSSETDSDLDGDHDDQHKRRK 392
                      |..|..|||                                    ||:..|...|
Mouse   271 ----------SFGQKSNLI------------------------------------DHEKIHTGEK 289

  Fly   393 KSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRHHNESQCRNAQK 457
                 .|.|..|.:.|.:|..|..||: .|: .:.|:.|..|...|..:..|..|...  ...:|
Mouse   290 -----PYKCNECGKSFSQKQSLVAHQK-VHT-GEKPYACNECGKAFPRVASLALHMRG--HTGEK 345

  Fly   458 RFLCHKCPLRFRWKHNLKTHFREHRITNQTFECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQW 522
            .:.|.||...|.....|..|.|.| ...:.:||.||.:.|.:..:||||:.| |..| |...|:.
Mouse   346 PYKCDKCGKAFSQFSMLIIHVRVH-TGEKPYECGECGKAFSQSSALTVHIRS-HTGE-KPYECKE 407

  Fly   523 CSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQL 587
            |.:.|......:.|.|.|               ...:|.|     |..|.         :|.||:
Mouse   408 CRKSFSHKKNFITHQKIH---------------TREKPYG-----CNECG---------KAFIQM 443

  Fly   588 ELKLSLSLHQSYDSPHNYSITNESGFELQLEDSETEDEMQPGVGSRPVYICELCSVQCKRKFEMI 652
            .   :|..||...:                             |.:| |:|:.|.....:|..:|
Mouse   444 S---NLVRHQRIHT-----------------------------GEKP-YLCKECGKAFSQKSNLI 475

  Fly   653 QHQRTMHRFDKMPHECDDCIFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYKFMWPENLEQHILL 717
            .|:: :|..:| |:||::                           |||.   |...:|     .:
Mouse   476 AHEK-IHSGEK-PYECNE---------------------------CGKA---FSQKQN-----FI 503

  Fly   718 QHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPHCDRTYQMKSRLNNHIRDVHINGDRKRK 782
            .|.|..            ||:...|          |..|.:.:...:.|..|:|. | .|:
Mouse   504 THQKVH------------TGEKPYD----------CNKCGKAFSQIASLTLHLRS-H-TGE---- 540

  Fly   783 EAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCT 847
               |.:.|..||......:.|..|||.||||||:.|:.|..||.:.:.|..|.|.||||||:.|.
Mouse   541 ---KPYECEKCGKAFSQCSLLNLHMRSHTGEKPYVCNECGKAFSQRTSLIVHMRGHTGEKPYECN 602

  Fly   848 VCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQS 912
            .|||.|::|..|..|:..|:|.||..|:.|.|::.|...|.||:::||||.|:||..||:.|.|.
Mouse   603 KCGKAFSQSSSLTIHIRGHTGEKPFDCSNCGKAFSQISSLTLHMRKHTGEKPYVCIECGKAFSQK 667

  Fly   913 STLEKHRLMRRH 924
            |.|.:|:.:..|
Mouse   668 SHLVRHQRIHTH 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368	7/20 (35%)
		C2H2 Zn finger	236..256	CDD:275368	8/19 (42%)
		C2H2 Zn finger	401..422	CDD:275368	7/20 (35%)
		C2H2 Zn finger	431..447	CDD:275368	4/15 (27%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		C2H2 Zn finger	490..511	CDD:275368	9/20 (45%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	668..690	CDD:275368	1/21 (5%)
		C2H2 Zn finger	698..715	CDD:275368	5/16 (31%)
		C2H2 Zn finger	753..774	CDD:275368	5/20 (25%)
		C2H2 Zn finger	790..810	CDD:275368	7/19 (37%)
		zf-H2C2_2	802..825	CDD:290200	12/22 (55%)
		COG5048	814..>886	CDD:227381	31/71 (44%)
		C2H2 Zn finger	818..838	CDD:275368	7/19 (37%)
		zf-H2C2_2	830..855	CDD:290200	14/24 (58%)
		C2H2 Zn finger	846..866	CDD:275368	8/19 (42%)
		zf-H2C2_2	859..883	CDD:290200	9/23 (39%)
		C2H2 Zn finger	874..894	CDD:275368	7/19 (37%)
		C2H2 Zn finger	902..924	CDD:275368	8/21 (38%)
Zfp74	NP_848471.2	KRAB	8..68	CDD:214630	5/8 (63%)
		C2H2 Zn finger	181..201	CDD:275368	7/20 (35%)
		COG5048	205..638	CDD:227381	157/654 (24%)
		C2H2 Zn finger	209..229	CDD:275368	8/19 (42%)
		C2H2 Zn finger	237..257	CDD:275368	6/19 (32%)
		C2H2 Zn finger	265..285	CDD:275368	9/74 (12%)
		C2H2 Zn finger	293..313	CDD:275368	7/20 (35%)
		C2H2 Zn finger	321..341	CDD:275368	5/21 (24%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		C2H2 Zn finger	377..397	CDD:275368	9/20 (45%)
		C2H2 Zn finger	405..425	CDD:275368	5/19 (26%)
		C2H2 Zn finger	433..453	CDD:275368	8/31 (26%)
		C2H2 Zn finger	461..481	CDD:275368	5/20 (25%)
		C2H2 Zn finger	489..509	CDD:275368	8/54 (15%)
		C2H2 Zn finger	517..537	CDD:275368	5/20 (25%)
		C2H2 Zn finger	545..565	CDD:275368	7/19 (37%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	601..621	CDD:275368	8/19 (42%)
		C2H2 Zn finger	629..649	CDD:275368	7/19 (37%)
		zf-H2C2_2	641..666	CDD:372612	13/24 (54%)
		C2H2 Zn finger	657..677	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000