DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and Prdm16

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_006539234.1	Gene:	Prdm16 / 70673	MGIID:	1917923	Length:	1277	Species:	Mus musculus

Alignment Length:	1145	Identity:	224/1145 - (19%)
Similarity:	354/1145 - (30%)	Gaps:	420/1145 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 TDTDNLLKLATPSKKYPDKLLSEILCELTEINLDATGS-QKFPQCLCSGCTKKLMGAYCYVKQA- 75
            |||:...:.:...|:..:.|.||..|  .:.|...:|| .|:.:..||...:.|  |.|.:.:.
Mouse   133 TDTEVSSQESCIKKQISEDLGSEKFC--VDANQAGSGSWLKYIRVACSCDDQNL--AMCQINEQI 193

  Fly    76 -------MAANELLMKHLKNGAAPTSTDCLQEAPMELCAEQHVEVKLETEDED----CGENDVTI 129
                   :...|.|:.|:|.||                  ..:.|...:.|||    |.|.|...
Mouse   194 YYKVIKDIEPGEELLVHVKEGA------------------YSLGVMAPSLDEDPTFRCDECDELF 240

  Fly   130 TCSELPEPDETDMESKK----SVDPLTMIETVKLEMEPRSV----EKPAYD--DPTSDFEDEDSL 184
            .|       ..|:...|    |.....:.|.:..|::|..:    :..|::  |....|.::.||
Mouse   241 QC-------RLDLRRHKKYACSSAGAQLYEGLGEELKPEGLGVGSDGQAHECKDCERMFPNKYSL 298

  Fly   185 DNLPLYNRIQKWKTGRKSVYKCHDCPRSFKRFDFLKRHEMRVHKPETRLYDCSLCIRKFSRSEAL 249
            :...:.:..::       .|||..||::|.....|.||:|. |....| ::|..|::.|:....|
Mouse   299 EQHMIVHTEER-------EYKCDQCPKAFNWKSNLIRHQMS-HDSGKR-FECENCVKVFTDPSNL 354

  Fly   250 EAHLKIHRNSKRSANISEHKKAKAVDLNLCKPHGY-----KLIECMICQSQYNKIADLRRHLEEH 309
            :.|::......|:....:..|..|....| |.|.:     |...|.:|...|.:.::|.||...|
Mouse   355 QRHIRSQHVGARAHACPDCGKTFATSSGL-KQHKHIHSTVKPFICEVCHKSYTQFSNLCRHKRMH 418

  Fly   310 PDIVSL-----CGR------------------------------------PNME----------- 322
            .|..:.     ||:                                    |.|:
Mouse   419 ADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHYTPGSIFTPGLPLTPSPMMDKTKPSPTLNHG 483

  Fly   323 -----------PHELAELF----------------------YP-------------------DSK 335
                       ||..:..|                      ||                   |:|
Mouse   484 GLGFSEYFPSRPHPGSLPFSAAPPAFPALTPGFPGIFPPSLYPRPPLLPPTPLLKSPLNHAQDAK 548

  Fly   336 --------------------------DLSEEQLINLIRKDLAAGIYQRFYSITNQSGYE------ 368
                                      ..|||:....:....|..:..|...:::.|.:|
Mouse   549 LPSPLGNPALPLVSAVSNSSQGATAATGSEEKFDGRLEDAYAEKVKNRSPDMSDGSDFEDINTTT 613

  Fly   369 -MDLDS-----SETDSDLDGDHDDQHKRRKKSR------------------------KATYSCEL 403
             .|||:     |:.|||||.|.|   |.:.|.:                        .|.||
Mouse   614 GTDLDTTTGTGSDLDSDLDSDRD---KGKDKGKPVESKPEFGGASVPPGAMNSVAEVPAFYS--- 672

  Fly   404 CQQKF---PRKYQLYDHQRQSHSWSDAPHVCGRCDG-RFVSLQ-----LLRHHNESQCRNAQKRF 459
             |..|   |.:..|........|......:..:..| .|:|:|     .|.:|:
Mouse   673 -QHSFFPPPEEQLLTASGAAGDSIKAIASIAEKYFGPGFMSMQEKKLGSLPYHS----------- 725

  Fly   460 LCHKCPLRF--RWKHNLKTHFREHRITNQTFECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQW 522
               ..|.:|  .:.|:|      :..|::..                .|.|.|.||...
Mouse   726 ---VFPFQFLPNFPHSL------YPFTDRAL----------------AHNLLVKAEPKS------ 759

  Fly   523 CSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQL 587
                           .|..||... |.||.....|::|..||...                   |
Mouse   760 ---------------PRDALKVGG-PSAECPFDLTTKPKEAKPAL-------------------L 789

  Fly   588 ELKLSLSLHQSYDSPHNYSI-----TNESGFELQLEDSETEDEMQPGVGSRPVYICELCSVQCKR 647
            ..|:.|......:.|.:.||     .:::|...:...:....|.:|||...   :.::|..|
Mouse   790 APKVPLIPSSGEEQPLDLSIGSRARASQNGGGREPRKNHVYGERKPGVSEG---LPKVCPAQ--- 848

  Fly   648 KFEMIQHQRTMHRFDKMPHECDDCIFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYKFMWPENLE 712
                :..|.::|.....|...|....:...:.:.|              ..|....|::.|..
Mouse   849 ----LPQQPSLHYAKPSPFFMDPIYSRVEKRKVAD--------------PVGVLKEKYLRPSP-- 893

  Fly   713 QHILLQHSKSSVSNPTGDRHTQGTGDLEKDA---TEDGIPLLQCPHCDRTYQMKS---RLNNHIR 771
               ||.|.:.|.....       |..||..|   .:.|..|...||  ..:..:|   .|::.|.
Mouse   894 ---LLFHPQMSAIETM-------TEKLESFAAMKADSGSSLQPLPH--HPFNFRSPPPTLSDPIL 946

  Fly   772 DVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASH-R 835
                   ||.||   |:.|..||.....:|.|..|:|.||||:|::|..|:.:|...|.|..| |
Mouse   947 -------RKGKE---RYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVR 1001

  Fly   836 RMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLH----LQQHTG 896
            .:|..||||.|.:|.:.|.:...|.||      ||.|:                |    :.||:|
Mouse  1002 NIHNKEKPFKCHLCNRCFGQQTNLDRH------LKKHE----------------HEGAPVSQHSG 1044

  Fly   897 ECPFVCGTCGERFIQSSTLEKHRLMRR----HFDEVEAWL 932
            ......||....  .:|..:.|.|:..    :|.|:..::
Mouse  1045 VLTNHLGTSASS--PTSESDNHALLDEKEDSYFSEIRNFI 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	19/79 (24%)
		C2H2 Zn finger	206..227	CDD:275368	8/20 (40%)
		C2H2 Zn finger	236..256	CDD:275368	5/19 (26%)
		C2H2 Zn finger	401..422	CDD:275368	4/23 (17%)
		C2H2 Zn finger	431..447	CDD:275368	5/21 (24%)
		C2H2 Zn finger	461..481	CDD:275368	4/21 (19%)
		C2H2 Zn finger	490..511	CDD:275368	2/20 (10%)
		C2H2 Zn finger	520..540	CDD:275368	0/19 (0%)
		C2H2 Zn finger	638..659	CDD:275368	3/20 (15%)
		C2H2 Zn finger	668..690	CDD:275368	2/21 (10%)
		C2H2 Zn finger	698..715	CDD:275368	3/16 (19%)
		C2H2 Zn finger	753..774	CDD:275368	5/23 (22%)
		C2H2 Zn finger	790..810	CDD:275368	7/19 (37%)
		zf-H2C2_2	802..825	CDD:290200	10/22 (45%)
		COG5048	814..>886	CDD:227381	22/72 (31%)
		C2H2 Zn finger	818..838	CDD:275368	7/20 (35%)
		zf-H2C2_2	830..855	CDD:290200	11/25 (44%)
		C2H2 Zn finger	846..866	CDD:275368	6/19 (32%)
		zf-H2C2_2	859..883	CDD:290200	6/23 (26%)
		C2H2 Zn finger	874..894	CDD:275368	1/23 (4%)
		C2H2 Zn finger	902..924	CDD:275368	5/25 (20%)
Prdm16	XP_006539234.1	PR-SET_PRDM16	61..223	CDD:380990	24/111 (22%)
		C2H2 Zn finger	233..253	CDD:275368	6/26 (23%)
		zf-C2H2	283..305	CDD:333835	4/21 (19%)
		C2H2 Zn finger	285..305	CDD:275368	4/19 (21%)
		zf-H2C2_2	297..321	CDD:372612	7/30 (23%)
		zf-C2H2	311..333	CDD:333835	10/22 (45%)
		C2H2 Zn finger	313..333	CDD:275368	8/20 (40%)
		zf-C2H2	339..360	CDD:333835	5/20 (25%)
		C2H2 Zn finger	341..359	CDD:275368	5/17 (29%)
		zf-C2H2	368..390	CDD:333835	5/22 (23%)
		C2H2 Zn finger	370..390	CDD:275368	5/20 (25%)
		zf-C2H2	396..418	CDD:333835	6/21 (29%)
		C2H2 Zn finger	398..418	CDD:275368	6/19 (32%)
		C2H2 Zn finger	427..445	CDD:275368	2/17 (12%)
		zf-C2H2	953..975	CDD:333835	7/21 (33%)
		C2H2 Zn finger	955..975	CDD:275368	7/19 (37%)
		zf-H2C2_2	967..991	CDD:372612	10/23 (43%)
		zf-C2H2	981..1004	CDD:333835	7/22 (32%)
		C2H2 Zn finger	983..1004	CDD:275368	7/20 (35%)
		zf-C2H2	1010..1032	CDD:333835	9/27 (33%)
		C2H2 Zn finger	1012..1032	CDD:275368	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910