Protein Alignment CG18476 and Zfp606

DIOPT Version :10

• Sequence 1: NP_731615.1
• Gene: CG18476 / 41404
• FlyBaseID: FBgn0037931
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: NP_080388.2
• Gene: Zfp606 / 67370
• MGIID: 1914620
• Length: 794
• Species: Mus musculus
• Alignment Length: 898
• Identity: 204/898 - (22%)
• Similarity: 315/898 - (35%)
• Gaps: 276/898 - (30%)

  Fly    86 LKNGAAPTSTDCLQEAPMELCAE--QHVEVKL-----ETEDEDCGENDVTITCSELPEP------ 137
            |:.|..|.|.:  |..|...|.|  ::.|.|.     ...:|:...|.:.:.......|
Mouse   115 LEQGEEPWSVE--QGYPKSSCPEWMRNTESKALIPAQSVSEEEQSSNGMMLERYIWDNPWLSRLG 177

  Fly   138 -----DETDM-ESKKSVDPLTMIETVKLEMEPRSVEKPAYDDPTSDF-----EDEDSLDNLP--- 188
                 |:.:| ...:|.....|:...|..:..|.          |:|     |...||:.:|
Mouse   178 VLGYGDQLEMYHMNQSTGMRQMVFMQKQVLSQRG----------SEFCELGTEYSQSLNLIPSQR 232

  Fly   189 ------LY---NRIQKWKTGRKSVYKCH-DCPRSFKRFDFLKRHEMRVH-----KPET--RLYDC 236
                  .|   ..::.|......:|... .|..|    |:.|.....|.     |.:|  .|:.|
Mouse   233 VSQLERFYKPDTHLESWSCNSAIMYADKVTCENS----DYNKAFCQSVQPVYPAKMQTGDNLFKC 293

  Fly   237 SLCIRKFSRSEALEAHLKIHRNSKRSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIAD 301
            :..::.|:.......|..:|...|.                    :|||         :|::|.:
Mouse   294 TDAVKSFNHIIQFGDHKAVHTGEKL--------------------YGYK---------EYHQIFN 329

  Fly   302 LRRHLEEHPDIVSLCGRPNMEPHELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFY------- 359
            ....|.|:|.: .:.|....:..|...:||..|  ..|.|.|..:.|......:::.:
Mouse   330 QSPSLIEYPKL-QIGGNQYEKYKEYENIFYFSS--FMEHQKIGSVEKTYKYNEWEKVFGYDSLLT 391

  Fly   360 ----SITNQSGYEMDLDSSETDSDLDGDHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQ 420
                :.|.:..||.:...:   |.:...:..|||:.....| .|.|:.|.:.|..:..|..|:|
Mouse   392 QHTSTYTAEKPYEFNKCGT---SFIWSSYLIQHKKTHPGEK-PYECDKCGKVFRNRSALTKHER- 451

  Fly   421 SHSWSDAPHVCGRCDGRFV-SLQLLRHHNESQCRNAQKRFLCHKCPLRFRWKHNLKTHFREHRIT 484
            :|: ...|:.|.:|...|. :..|:.|   ::....:|.::|::|...|.|..:|..|.|.| ..
Mouse   452 THT-GVKPYECNKCGKAFSWNSHLIVH---TRIHTGEKPYVCNECGKSFNWNSHLIGHQRTH-TG 511

  Fly   485 NQTFECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPL 549
            .:.|||:||.:.|.....|..| :.:|..| |...|..|.:.|..:..|.||.:.|
Mouse   512 EKPFECTECGKSFSWSSHLIAH-MRMHTGE-KPFKCDECEKAFRDYSALSKHERTH--------- 565

  Fly   550 AETLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFE 614
                       :|||...|..|...|                |.|.|
Mouse   566 -----------SGAKPYKCTECGKSF----------------SWSSH------------------ 585

  Fly   615 LQLEDSETEDEMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCVSKS 679
                                                :|.|||| |..:| |:.|.:
Mouse   586 ------------------------------------LIAHQRT-HTGEK-PYNCQE--------- 603

  Fly   680 IMDHHRQGQCSSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDAT 744
                              |||.   |.....|.:|.:: ||
Mouse   604 ------------------CGKA---FRERSALTKHEII-HS------------------------ 622

  Fly   745 EDGIPLLQCPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRR 809
              ||...:|..|.::....:.|..|.| .| .|:       |.:.|:.||.....:..||.|.|.
Mouse   623 --GIKPYECNKCGKSCSQMAHLVRHQR-TH-TGE-------KPYECNKCGKSFSQSCHLVAHRRI 676

  Fly   810 HTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKC 874
            ||||||:||:.||.:|...|.|.:|||.||||||:.|..|||.|..|..|..|:..|:|.||:||
Mouse   677 HTGEKPYKCNQCERSFNCSSHLIAHRRTHTGEKPYRCNECGKAFNESSSLIVHLRNHTGEKPYKC 741

  Fly   875 TYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHRLMRRHFDE 927
            .:|||::.:...|.:|.:.|:||..|:|..||..|...|.|.:|:  :.|.:|
Mouse   742 NHCEKAFCKNSSLIIHQRMHSGEKRFICNQCGRAFSGHSALLQHQ--KNHSEE 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	C2H2 Zn finger	206..227	CDD:275368	4/21 (19%)
		C2H2 Zn finger	236..256	CDD:275368	3/19 (16%)
		C2H2 Zn finger	401..422	CDD:275368	6/20 (30%)
		C2H2 Zn finger	431..447	CDD:275368	4/16 (25%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		C2H2 Zn finger	490..511	CDD:275368	6/20 (30%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	668..690	CDD:275368	1/21 (5%)
		C2H2 Zn finger	698..715	CDD:275368	5/16 (31%)
		C2H2 Zn finger	753..774	CDD:275368	5/20 (25%)
		C2H2 Zn finger	790..810	CDD:275368	7/19 (37%)
		COG5048	814..>886	CDD:227381	35/71 (49%)
		C2H2 Zn finger	818..838	CDD:275368	9/19 (47%)
		C2H2 Zn finger	846..866	CDD:275368	8/19 (42%)
		C2H2 Zn finger	874..894	CDD:275368	6/19 (32%)
		C2H2 Zn finger	902..924	CDD:275368	7/21 (33%)
Zfp606	NP_080388.2	KRAB	63..123	CDD:214630	3/7 (43%)
		COG5048	386..792	CDD:227381	145/577 (25%)
		C2H2 Zn finger	406..425	CDD:275368	4/21 (19%)
		C2H2 Zn finger	433..453	CDD:275368	6/20 (30%)
		C2H2 Zn finger	461..481	CDD:275368	5/22 (23%)
		C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		C2H2 Zn finger	517..537	CDD:275368	6/20 (30%)
		C2H2 Zn finger	545..565	CDD:275368	6/19 (32%)
		C2H2 Zn finger	573..593	CDD:275368	11/90 (12%)
		C2H2 Zn finger	601..621	CDD:275368	7/50 (14%)
		C2H2 Zn finger	629..649	CDD:275368	5/20 (25%)
		C2H2 Zn finger	657..677	CDD:275368	7/19 (37%)
		C2H2 Zn finger	685..705	CDD:275368	9/19 (47%)
		C2H2 Zn finger	713..733	CDD:275368	8/19 (42%)
		C2H2 Zn finger	741..761	CDD:275368	6/19 (32%)
		C2H2 Zn finger	769..789	CDD:275368	7/21 (33%)