DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18476 and ZNF574

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001317448.1	Gene:	ZNF574 / 64763	HGNCID:	26166	Length:	986	Species:	Homo sapiens

Alignment Length:	903	Identity:	198/903 - (21%)
Similarity:	296/903 - (32%)	Gaps:	264/903 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 YDCSLCIRKFSRSEALEAHLKIH--RNSKRSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQY 296
            |.||.|.:.:...|.:..|...|  :.......:::.....|.|    ...|..|.:.::.:|||
Human   106 YVCSECNQLYGSLEEVLMHQNSHVPQQHFELVGVADPGVTVATD----TASGTGLYQTLVQESQY 166

  Fly   297 NKI---------ADLRRHLEEH------PDIVSLCGRPNMEPHELAELFYP--DSKDL--SEEQL 342
            ..:         :.|..|.|.|      .:.|.....|...|...:.:.|.  |.|.|  |:|..
Human   167 QCLECGQLLMSPSQLLEHQELHLKMMAPQEAVPAEPSPKAPPLSSSTIHYECVDCKALFASQELW 231

  Fly   343 INLIRKDLAAG-------------------------IYQRFYSITNQSGYEMDLDSSE------- 375
            :|..:..|.|.                         ..:..|....:.|....:.|:.
Human   232 LNHRQTHLRATPTKAPAPVVLGSPVVLGPPVGQARVAVEHSYRKAEEGGEGATVPSAAATTTEVV 296

  Fly   376 TDSDLDGDHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQR-------------------QS 421
            |:.:|                ..|.|..|.|.|.......:||.                   |:
Human   297 TEVEL----------------LLYKCSECSQLFQLPADFLEHQATHFPAPVPESQEPALQQEVQA 345

  Fly   422 HSWSDAP-----------HVC----GRCDGRFVSLQLLRHHNESQCRN-AQKRFLCHKCPLRFRW 470
            .|.::.|           |..    |...||....:..|.:|..:... |.:...|..|...|..
Human   346 SSPAEVPVSQPDPLPASDHSYELRNGEAIGRDRRGRRARRNNSGEAGGAATQELFCSACDQLFLS 410

  Fly   471 KHNLKTHFREHRITNQTFECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVK 535
            .|.|:.|.|.||  ...|:|..|.|||....||..| |..|:.||..: |..|...|.....|:.
Human   411 PHQLQQHLRSHR--EGVFKCPLCSRVFPSPSSLDQH-LGDHSSESHFL-CVDCGLAFGTEALLLA 471

  Fly   536 HLKRHGLKE-HDIPLAETLIAATS-----RPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLS 594
            |.:.|.... |..|..:|.:..|.     |.:|...:......:..|..|
Human   472 HRRAHTPNPLHSCPCGKTFVNLTKFLYHRRTHGVGGVPLPTTPVPPEEPV--------------- 521

  Fly   595 LHQSYDSPHNYSITNESGFELQLEDSETEDEMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMH 659
              ..:..|    ...|:| |.:..:....:|...|..:...|.|.|||.:..:..::.:|||.:|
Human   522 --IGFPEP----APAETG-EPEAPEPPVSEETSAGPAAPGTYRCLLCSREFGKALQLTRHQRFVH 579

  Fly   660 RFDKMPHECDDC--IFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYKFMWPENLEQHILLQHSKS 722
            |.::. |:|..|  :||  .||.:.:|.  :..:.|:...|..||..|..|.||.:|.|..
Human   580 RLERR-HKCSICGKMFK--KKSHVRNHL--RTHTGERPFPCPDCSKPFNSPANLARHRLTH---- 635

  Fly   723 SVSNPTGDRHTQGTGDLEKDAT---------------------EDGIPL---------------- 750
                 ||:|..: .||..|..|                     |.|:..
Human   636 -----TGERPYR-CGDCGKAFTQSSTLRQHRLVHAQHFPYRCQECGVRFHRPYRLLMHRYHHTGE 694

  Fly   751 --LQCPHCDRTYQMKSRLNNHIRDVHINGDRKR-----------------------KEAIKRFLC 790
              .:|..|.|::.::..|..|...||......|                       .:|.:||.|
Human   695 YPYKCRECPRSFLLRRLLEVHQLVVHAGRQPHRCPSCGAAFPSSLRLREHRCAAAAAQAPRRFEC 759

  Fly   791 SLCGMETRSAAALVTHMRRHTGEKP---------------------------------------- 815
            ..||.:..|||.|..|...|....|
Human   760 GTCGKKVGSAARLQAHEAAHAAAGPGEVLAKEPPAPRAPRATRAPVASPAALGSTATASPAAPAR 824

  Fly   816 ---FKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYC 877
               .:|..|:..|...:.|..|||:||||:|:.|..|||.|.:|..||.|...|:|.:|..|..|
Human   825 RRGLECSECKKLFSTETSLQVHRRIHTGERPYPCPDCGKAFRQSTHLKDHRRLHTGERPFACEVC 889

  Fly   878 EKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHRLMRRHFDEVEAWLRRQ 935
            .|::..:..|..|.:.||||.|:.|..||:.:...|.|.|||  :.|..:.:|.:|:|
Human   890 GKAFAISMRLAEHRRIHTGERPYSCPDCGKSYRSFSNLWKHR--KTHQQQHQAAVRQQ 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368	5/19 (26%)
		C2H2 Zn finger	401..422	CDD:275368	7/39 (18%)
		C2H2 Zn finger	431..447	CDD:275368	4/19 (21%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		C2H2 Zn finger	490..511	CDD:275368	9/20 (45%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	638..659	CDD:275368	7/20 (35%)
		C2H2 Zn finger	668..690	CDD:275368	7/23 (30%)
		C2H2 Zn finger	698..715	CDD:275368	7/16 (44%)
		C2H2 Zn finger	753..774	CDD:275368	5/20 (25%)
		C2H2 Zn finger	790..810	CDD:275368	8/19 (42%)
		zf-H2C2_2	802..825	CDD:290200	6/65 (9%)
		COG5048	814..>886	CDD:227381	28/114 (25%)
		C2H2 Zn finger	818..838	CDD:275368	7/19 (37%)
		zf-H2C2_2	830..855	CDD:290200	14/24 (58%)
		C2H2 Zn finger	846..866	CDD:275368	9/19 (47%)
		zf-H2C2_2	859..883	CDD:290200	9/23 (39%)
		C2H2 Zn finger	874..894	CDD:275368	5/19 (26%)
		C2H2 Zn finger	902..924	CDD:275368	8/21 (38%)
ZNF574	NP_001317448.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100