DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and PRDM16

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_071397.3	Gene:	PRDM16 / 63976	HGNCID:	14000	Length:	1276	Species:	Homo sapiens

Alignment Length:	1139	Identity:	196/1139 - (17%)
Similarity:	316/1139 - (27%)	Gaps:	478/1139 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 GAYCYVKQAMAANELL----------MKHLKNGAAPTSTDCLQEAPMELCAEQHVEVKLETE--- 118
            |...:.|:.|.|.|.|          .|....|.....|| ::.:|.|.|..: :...|.:|
Human    95 GLGVWAKRKMEAGERLGPCVVVPRAAAKETDFGWEQILTD-VEVSPQEGCITK-ISEDLGSEKFC 157

  Fly   119 -DED--------------CGENDVTITCSELPEPDETDMESKKSVDP-LTMIETVKLEMEPRSVE 167
             |.:              |..:|..:|..::.|  :...:..|.::| ..::..||..:.|....
Human   158 VDANQAGAGSWLKYIRVACSCDDQNLTMCQISE--QIYYKVIKDIEPGEELLVHVKEGVYPLGTV 220

  Fly   168 KPAYD-DPTSDFEDEDSLDNLPLYNRIQKWKTGRKSVYKCHDCPRSFKRFDFLKRHE-------- 223
            .|..| :||                            ::|.:|...|:....|:||:
Human   221 PPGLDEEPT----------------------------FRCDECDELFQSKLDLRRHKKYTCGSVG 257

  Fly   224 -------MRVHKPE------TRLYDCSLCIRKFSRSEALEAHLKIHRNSKRSANISEHKKAKAVD 275
                   ....|||      .:.::|..|.|.|....:||.|:.||...:.
Human   258 AALYEGLAEELKPEGLGGGSGQAHECKDCERMFPNKYSLEQHMVIHTEERE-------------- 308

  Fly   276 LNLCKPHGYKLIECMICQSQYNKIADLRRHLEEHPDIVSLCGRPNMEPHELAELFYPDSKDLSEE 340
                    ||   |..|...:|..::|.||...|
Human   309 --------YK---CDQCPKAFNWKSNLIRHQMSH------------------------------- 331

  Fly   341 QLINLIRKDLAAGIYQRFYSITNQSGYEMDLDSSETDSDLDGDHDDQHKRRKKSRKATYSCELCQ 405
                                                         |..||        :.||.|.
Human   332 ---------------------------------------------DSGKR--------FECENCV 343

  Fly   406 QKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRHHNESQCRNAQKRFLCHKCPLRFRW 470
            :.|.....|..|.|..|..:.| |.|..|...|.:...|:.|  ....:..|.|:|..|...:..
Human   344 KVFTDPSNLQRHIRSQHVGARA-HACPDCGKTFATSSGLKQH--KHIHSTVKPFICEVCHKSYTQ 405

  Fly   471 KHNLKTHFREHRITNQTFECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVK 535
            ..||..|.|.|.......:|.:|.::|....||..|.             ::|..|        .
Human   406 FSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHR-------------RFCEGK--------N 449

  Fly   536 HLKRHGLKEHDIPLAETLIAATSRPNGAKRITCRMCNLHFERIVDLRAH---------------- 584
            |....|:....:||..:.:...::|:.    :....:|.|......|.|
Human   450 HYTPGGIFAPGLPLTPSPMMDKAKPSP----SLNHASLGFNEYFPSRPHPGSLPFSTAPPTFPAL 510

  Fly   585 ------------------IQLELKLSLSLHQSYDS-----------PHNYSITN----------- 609
                              :.....|...|:.:.|:           |...:::|
Human   511 TPGFPGIFPPSLYPRPPLLPPTSLLKSPLNHTQDAKLPSPLGNPALPLVSAVSNSSQGTTAAAGP 575

  Fly   610 ESGFELQLED----------------SETED---------EMQPGVGS----------------- 632
            |..||.:|||                |:.||         :...|.||
Human   576 EEKFESRLEDSCVEKLKTRSSDMSDGSDFEDVNTTTGTDLDTTTGTGSDLDSDVDSDPDKDKGKG 640

  Fly   633 -----RPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHE--------CDDCIFKCVSKSIMDHH 684
                 :|.:...|...........:....:.|.|...|.|        ..|.| |.::.....:.
Human   641 KSAEGQPKFGGGLAPPGAPNSVAEVPVFYSQHSFFPPPDEQLLTATGAAGDSI-KAIASIAEKYF 704

  Fly   685 RQGQCSSTEKK------HACGKCSYKFMWPENLEQHI------LLQHSKSSVSNPTGDRHTQGTG 737
            ..|.....|||      |:    ::.|.:..|....:      .|.|:....:.|...|
Human   705 GPGFMGMQEKKLGSLPYHS----AFPFQFLPNFPHSLYPFTDRALAHNLLVKAEPKSPR------ 759

  Fly   738 DLEKDATEDGIPLLQCPH-----------------------------CDRTYQMKSRLNNH---- 769
                ||.:.|.|..:||.                             .|.:...::|.:.:
Human   760 ----DALKVGGPSAECPFDLTTKPKDVKPILPMPKGPSAPASGEEQPLDLSIGSRARASQNGGGR 820

  Fly   770 -IRDVHINGDR----------------------------------------KRK----------- 782
             .|..|:.|:|                                        |||
Human   821 EPRKNHVYGERKLGAGEGLPQVCPARMPQQPPLHYAKPSPFFMDPIYSRVEKRKVTDPVGALKEK 885

  Fly   783 ----------------EAIKRFLCSLCGMETRSAAAL--VTHMRRHTGEKPFKCDLCEMAFPRHS 829
                            |.:...|.|...|:..|.::|  :.|       .||.       |....
Human   886 YLRPSPLLFHPQMSAIETMTEKLESFAAMKADSGSSLQPLPH-------HPFN-------FRSPP 936

  Fly   830 ELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQ- 893
            ...|...:..|::.:.|..|||.|.||..|.||:.||:|.:|::|.||::|:..:.:|:.|::.
Human   937 PTLSDPILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNI 1001

  Fly   894 HTGECPFVCGTCGERFIQSSTLEKHRLMRRHFDE 927
            |..|.||.|..|...|.|.:.|::|  :::|..|
Human  1002 HNKEKPFKCHLCNRCFGQQTNLDRH--LKKHEHE 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	6/26 (23%)
		C2H2 Zn finger	206..227	CDD:275368	6/35 (17%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		C2H2 Zn finger	401..422	CDD:275368	7/20 (35%)
		C2H2 Zn finger	431..447	CDD:275368	4/15 (27%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	490..511	CDD:275368	6/20 (30%)
		C2H2 Zn finger	520..540	CDD:275368	3/19 (16%)
		C2H2 Zn finger	638..659	CDD:275368	1/20 (5%)
		C2H2 Zn finger	668..690	CDD:275368	4/21 (19%)
		C2H2 Zn finger	698..715	CDD:275368	2/16 (13%)
		C2H2 Zn finger	753..774	CDD:275368	5/54 (9%)
		C2H2 Zn finger	790..810	CDD:275368	5/21 (24%)
		zf-H2C2_2	802..825	CDD:290200	4/24 (17%)
		COG5048	814..>886	CDD:227381	23/71 (32%)
		C2H2 Zn finger	818..838	CDD:275368	2/19 (11%)
		zf-H2C2_2	830..855	CDD:290200	7/24 (29%)
		C2H2 Zn finger	846..866	CDD:275368	10/19 (53%)
		zf-H2C2_2	859..883	CDD:290200	11/23 (48%)
		C2H2 Zn finger	874..894	CDD:275368	6/20 (30%)
		C2H2 Zn finger	902..924	CDD:275368	6/21 (29%)
PRDM16	NP_071397.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68
		SET	84..209	CDD:214614	22/117 (19%)
		C2H2 Zn finger	283..303	CDD:275368	7/19 (37%)
		zf-H2C2_2	295..319	CDD:290200	9/48 (19%)
		C2H2 Zn finger	311..331	CDD:275368	6/19 (32%)
		zf-C2H2	337..358	CDD:278523	6/20 (30%)
		C2H2 Zn finger	339..357	CDD:275368	6/17 (35%)
		zf-C2H2	366..388	CDD:278523	6/23 (26%)
		C2H2 Zn finger	368..388	CDD:275368	5/21 (24%)
		zf-C2H2_8	369..450	CDD:292531	21/103 (20%)
		zf-C2H2	394..416	CDD:278523	7/21 (33%)
		C2H2 Zn finger	396..416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	425..443	CDD:275368	6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	533..657		19/123 (15%)
		Interaction with CTBP1, CTBP2 and ZNF516. /evidence=ECO:0000250\|UniProtKB:A2A935	679..1038		74/386 (19%)
		Mediates interaction with SKI and regulation of TGF-beta signaling. /evidence=ECO:0000269\|PubMed:19049980	739..1276		63/321 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	772..804		1/31 (3%)
		COG5048	931..>1083	CDD:227381	35/112 (31%)
		zf-C2H2	951..973	CDD:278523	10/21 (48%)
		C2H2 Zn finger	953..973	CDD:275368	10/19 (53%)
		zf-H2C2_2	965..989	CDD:290200	11/23 (48%)
		zf-C2H2	979..1002	CDD:278523	6/22 (27%)
		C2H2 Zn finger	981..1002	CDD:275368	6/20 (30%)
		zf-C2H2	1008..1030	CDD:278523	7/23 (30%)
		C2H2 Zn finger	1010..1030	CDD:275368	6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1033..1065		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1163
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910