DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and Zfp808

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001034328.2	Gene:	Zfp808 / 630579	MGIID:	3704127	Length:	753	Species:	Mus musculus

Alignment Length:	917	Identity:	231/917 - (25%)
Similarity:	350/917 - (38%)	Gaps:	214/917 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LATPSKKYPDKLLSEILCELTEINLDATGSQKFPQCLCSGCTKKLMGAYCYVKQAMAANELLMKH 85
            |..||:|   ||..:::.| |..||:|.|.....|.:...|........|...|:
Mouse    20 LLDPSQK---KLYKDVMLE-TYRNLNAIGFNWEAQNIEEHCQSSRRHRRCERSQS---------- 70

  Fly    86 LKNGAAPTSTDCLQEAPMELCAEQHVE-------VKLETEDEDCGENDVTITCSELPEPDETDME 143
                |...|....::....|.|..|.:       .|:.:||..|.|:
Mouse    71 ----AEKPSEYTQRDKAFALRAHSHAQRHERIHTEKIPSEDIHCVED------------------ 113

  Fly   144 SKKSVDPLTMIETVKLEMEPRSVEKPAYDDPTSDFEDEDSLDNLPLYNRIQKWKTGRKSVYKCHD 208
                |.|.|                                 :|.::.|.|   ||:|. |:|..
Mouse   114 ----VLPYT---------------------------------SLQVHKRTQ---TGQKP-YECKQ 137

  Fly   209 CPRSFKRFDFLKRHEMRVHKPETRLYDCSLCIRKFSRSEALEAHLKIHRNSKRSANISEHKKAKA 273
            |.:.|.:...||||| |.|..| :.:.|:.|...||....|:.|:::|.
Mouse   138 CGKGFAKPSHLKRHE-RFHTVE-QPFICNECDEVFSFKHHLQTHIRVHT---------------- 184

  Fly   274 VDLNLCKPHGYKLIECMICQSQYNKIADLRRHLEEHPDIVSLCGRPNMEPHELAELFYPDSKDLS 338
                     |.|..:|.:|...::|    ..||:.|           ...|...:.:..|..|.:
Mouse   185 ---------GEKPFKCNLCDKSFSK----HNHLQSH-----------RRTHTGEKPYKCDQCDKA 225

  Fly   339 EEQLINLIRKDLAAGIYQRFYSI-TNQSGYEMDLDSSETDSDLDGDHDDQHKRRKKSRKATYSCE 402
            ..:..||          |....| |.:..|:.| ...:|.|  :..|..:|.|.....| .|.|.
Mouse   226 FSEKCNL----------QTHIRIHTGEKPYKCD-QCDKTFS--EKCHLQKHIRIHTGEK-PYKCN 276

  Fly   403 LCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRHHNESQCRNAQKRFLCHKCPLR 467
            .|.:.|.:...|..| |::|: .:.|:.|.:||..|.....|:.|..:  ...:|.|.|::|...
Mouse   277 QCDKAFSQYSTLQTH-RRTHT-GEKPYKCNQCDKAFSQYGNLQTHRRT--HTGEKPFKCNQCDKA 337

  Fly   468 FRWKHNLKTHFREHRITNQTFECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDY 532
            |.....|:||.|.| ...:.::|::|.:.|.:|.||..| :.:|..| |...|..|::.|..:.:
Mouse   338 FSQYSTLQTHRRTH-TGEKPYKCNQCDKAFSEKCSLQRH-IRIHTGE-KPYKCNQCNKAFSHNYH 399

  Fly   533 LVKHLKRHGLKEHDIPLAETLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLH- 596
            |..|.:.|                    .|.|...|..|:..|                  |:|
Mouse   400 LHIHRRTH--------------------TGEKPYKCNQCDKAF------------------SIHF 426

  Fly   597 --QSYDSPHNYSITNESGFELQ------LEDSETEDEMQPGVGSRPVYICELCSVQCKRKFEMIQ 653
              |::...|    |.|..::..      .|....::.::...|.:| |.|..|.....:.|.:..
Mouse   427 PLQNHKRTH----TGEKPYKCNQCDKAFSEKCHLQNHIRIHTGEKP-YKCNQCDKAFSQYFSLQT 486

  Fly   654 HQRTMHRFDKMPHECDDCIFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYKFMWPENLEQHILLQ 718
            |:| :|..:| |.:|:.|.......|.:..||  :..:.||...|.:|...|.....|:.|....
Mouse   487 HRR-IHTGEK-PFKCNQCDKAFSQYSTLQTHR--RTHTGEKPFKCNQCDKAFSKHSTLQSHRRTH 547

  Fly   719 HSKSSVSNPTGDRHTQGTGDLEKD-ATEDGIPLLQCPHCDRTYQMKSRLNNHIRDVHINGDRKRK 782
            ..:........|:.......|:.. .|..|....:|..||:.:..|..|..||| :| .|:
Mouse   548 SGEKPFKCSQCDKAFSQYNTLQAHRRTHSGEKPFKCDQCDKAFSEKCNLQKHIR-IH-TGE---- 606

  Fly   783 EAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCT 847
               |.:.|:.|.........|.||.|.|||||||||:.|:.||.|||.|.:|||.|||||||.|.
Mouse   607 ---KPYKCNQCDKAFSQYNTLQTHRRIHTGEKPFKCNQCDKAFSRHSTLQTHRRTHTGEKPFKCN 668

  Fly   848 VCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQS 912
            .|.|.|::...|:.|..||:|.||:||..|:|::....:|:.|::.||||.|:.|..|.:.|.|.
Mouse   669 QCDKVFSQYSNLQTHRRTHTGEKPYKCDQCDKAFSMKCNLQNHVRIHTGEKPYKCNQCDKAFFQY 733

  Fly   913 STLEKHR 919
            |.|..||
Mouse   734 SNLHIHR 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	16/62 (26%)
		C2H2 Zn finger	206..227	CDD:275368	9/20 (45%)
		C2H2 Zn finger	236..256	CDD:275368	6/19 (32%)
		C2H2 Zn finger	401..422	CDD:275368	6/20 (30%)
		C2H2 Zn finger	431..447	CDD:275368	5/15 (33%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		C2H2 Zn finger	490..511	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	668..690	CDD:275368	5/21 (24%)
		C2H2 Zn finger	698..715	CDD:275368	4/16 (25%)
		C2H2 Zn finger	753..774	CDD:275368	8/20 (40%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		zf-H2C2_2	802..825	CDD:290200	14/22 (64%)
		COG5048	814..>886	CDD:227381	37/71 (52%)
		C2H2 Zn finger	818..838	CDD:275368	11/19 (58%)
		zf-H2C2_2	830..855	CDD:290200	15/24 (63%)
		C2H2 Zn finger	846..866	CDD:275368	6/19 (32%)
		zf-H2C2_2	859..883	CDD:290200	11/23 (48%)
		C2H2 Zn finger	874..894	CDD:275368	5/19 (26%)
		C2H2 Zn finger	902..924	CDD:275368	8/18 (44%)
Zfp808	NP_001034328.2	KRAB	4..>45	CDD:214630	11/28 (39%)
		KRAB	4..40	CDD:279668	8/23 (35%)
		COG5048	<130..284	CDD:227381	48/210 (23%)
		C2H2 Zn finger	135..155	CDD:275368	9/20 (45%)
		C2H2 Zn finger	163..183	CDD:275368	6/19 (32%)
		zf-H2C2_2	175..199	CDD:290200	7/48 (15%)
		C2H2 Zn finger	191..211	CDD:275368	6/34 (18%)
		zf-H2C2_2	203..227	CDD:290200	6/34 (18%)
		C2H2 Zn finger	219..239	CDD:275368	5/29 (17%)
		zf-H2C2_2	231..255	CDD:290200	8/34 (24%)
		C2H2 Zn finger	247..267	CDD:275368	6/22 (27%)
		zf-H2C2_2	259..284	CDD:290200	8/25 (32%)
		C2H2 Zn finger	275..295	CDD:275368	6/20 (30%)
		zf-H2C2_2	288..312	CDD:290200	9/25 (36%)
		C2H2 Zn finger	303..323	CDD:275368	6/21 (29%)
		zf-H2C2_2	315..340	CDD:290200	7/26 (27%)
		COG5048	327..728	CDD:227381	132/459 (29%)
		C2H2 Zn finger	331..351	CDD:275368	7/19 (37%)
		zf-H2C2_2	344..367	CDD:290200	7/23 (30%)
		C2H2 Zn finger	359..379	CDD:275368	7/20 (35%)
		zf-H2C2_2	371..396	CDD:290200	9/26 (35%)
		C2H2 Zn finger	387..407	CDD:275368	5/19 (26%)
		C2H2 Zn finger	415..435	CDD:275368	6/37 (16%)
		zf-H2C2_2	428..451	CDD:290200	4/26 (15%)
		C2H2 Zn finger	443..463	CDD:275368	1/19 (5%)
		zf-H2C2_2	455..480	CDD:290200	5/25 (20%)
		C2H2 Zn finger	471..491	CDD:275368	5/20 (25%)
		zf-H2C2_2	483..508	CDD:290200	7/26 (27%)
		C2H2 Zn finger	499..519	CDD:275368	5/21 (24%)
		zf-H2C2_2	512..535	CDD:290200	6/24 (25%)
		C2H2 Zn finger	527..547	CDD:275368	5/19 (26%)
		zf-H2C2_2	540..564	CDD:290200	3/23 (13%)
		C2H2 Zn finger	555..575	CDD:275368	2/19 (11%)
		zf-H2C2_2	568..591	CDD:290200	6/22 (27%)
		C2H2 Zn finger	583..603	CDD:275368	8/20 (40%)
		zf-H2C2_2	595..620	CDD:290200	9/33 (27%)
		C2H2 Zn finger	611..631	CDD:275368	6/19 (32%)
		zf-H2C2_2	624..648	CDD:290200	16/23 (70%)
		C2H2 Zn finger	639..659	CDD:275368	11/19 (58%)
		zf-H2C2_2	652..676	CDD:290200	15/23 (65%)
		C2H2 Zn finger	667..687	CDD:275368	6/19 (32%)
		zf-H2C2_2	679..703	CDD:290200	11/23 (48%)
		C2H2 Zn finger	695..715	CDD:275368	5/19 (26%)
		zf-H2C2_2	707..730	CDD:290200	9/22 (41%)
		C2H2 Zn finger	723..743	CDD:275368	8/18 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100