DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and ZNF624

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_065838.2	Gene:	ZNF624 / 57547	HGNCID:	29254	Length:	865	Species:	Homo sapiens

Alignment Length:	942	Identity:	229/942 - (24%)
Similarity:	356/942 - (37%)	Gaps:	244/942 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KLATPSKKYPDKLLSE-ILCELTEINLDATGSQKFPQCLCSGCTKKLMGAYCYVKQAMAANELLM 83
            |.||.:|...:.|..| ||.:|||..|               ...::.|.:.:..:.:.......
Human   134 KKATRTKAISEDLSQEAILEKLTENGL---------------WDSRMEGLWKWNDRILRLQNNQE 183

  Fly    84 KHLKNGAAP-TSTDCLQEA--------PMELCAEQHVEVKLETEDEDCGENDVTITCSELPEPDE 139
            .||.....| ..|...|..        |....|.:.:..:.:|::|:..||...||.:.|.:...
Human   184 NHLSQRIIPLKKTPTSQRGFRFESILIPEPGIATEELHSRCQTQEENFTENLNLITDTHLGKIIC 248

  Fly   140 TDMESKKSVDPLTMIETVKLEMEPRS--VEKPAYDDPTSDFEDEDSLDNLPLYNRIQKWKTGRKS 202
            .:|:..|::.     :|.:|.:..:|  .|||
Human   249 KEMKGSKAIR-----QTSELTLGKKSNNKEKP--------------------------------- 275

  Fly   203 VYKCHDCPRSFKRFDFLKRHEMRVHKPETRLYDCSLCIRKFSRSEALEAHLKIHRNSK------- 260
             |||..|.::|.....|.:|: |.|..| :.|:|:.|.:.||:...|..|.|||...|
Human   276 -YKCSTCEKAFHYRSLLIQHQ-RTHTKE-KPYECNECGKTFSQPSYLSQHKKIHTGEKPYKCNEC 337

  Fly   261 -----RSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIADLRRHLE----EHPDIVSLC 316
                 .|:::..|::....:    ||:     :|.:|...:::.|.|.:|..    |.|...|.|
Human   338 GKAFIASSSLMVHQRIHTKE----KPY-----QCNVCGKSFSQCARLNQHQRIQTGEKPYKCSEC 393

  Fly   317 GRPNMEPHELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQSGYEMDLDSSETDSDLD 381
            |:...:..:||.
Human   394 GKAFSDKSKLAR----------------------------------------------------- 405

  Fly   382 GDHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRH 446
              |.:.|...|     .|.|:.|.:.|..|..|..||: :|: .:.|:.|..|...|.:..:...
Human   406 --HQETHNGEK-----PYKCDDCGKAFRNKSYLSVHQK-THT-EEKPYQCNECGKSFKNTTIFNV 461

  Fly   447 HNESQCRNAQKRFLCHKCPLRFRWKHNLKTHFREHRITNQTFECSECKRVFDKKKSLTVHLLSVH 511
            |  .:....:|.|.|::|...:|...:|..|.|.| ...:.:||:||.:.|::..:.|.| ..:|
Human   462 H--QRIHTGEKPFRCNECGKAYRSNSSLIVHIRTH-TGEKPYECNECGKAFNRIANFTEH-QRIH 522

  Fly   512 AEESKLIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAATSRPNGAKRITCRMCNLHFE 576
            ..| |...|..|.:.|..:..|..|.:.|                    .|.|...|..|...|.
Human   523 TGE-KPYKCNECGKAFINYSCLTVHHRMH--------------------TGEKPYKCTECGKAFM 566

  Fly   577 RIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSETEDEMQPGVGSRPVYICELC 641
            |            ..||.:||...:.....:.||.|...:::...|..: :...|.:| |.|
Human   567 R------------SSSLIIHQRIHTEEKPYLCNECGESFRIKSHLTVHQ-RIHTGEKP-YKC--- 614

  Fly   642 SVQCKRKF-EMI---QHQRTMHRFDKMPHECDDCIFKCVSKSIMDHHRQGQCSSTEKKHACGKCS 702
             ..|:|.| :|:   :||: :|...| |::|.||.....:||.:..|:  :..:.||.:.|.:|.
Human   615 -TDCERAFTKMVNLKEHQK-IHTGVK-PYKCYDCGKSFRTKSYLIVHQ--RTHTGEKPYKCNECE 674

  Fly   703 YKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPHCDRTYQMKSRLN 767
            ..|   .|..|  |..|.:         |||             |....:|..|.:.:...|..|
Human   675 KAF---TNTSQ--LTVHQR---------RHT-------------GEKPYKCNECGKVFTSNSGFN 712

  Fly   768 NHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELA 832
            .|.| .| .|:       |.|.|:.||........:..|.:.|:||||:|||:|..||.|.|.|.
Human   713 THQR-TH-TGE-------KPFKCNDCGKAFSQMVHVTEHQKIHSGEKPYKCDVCGKAFRRGSYLT 768

  Fly   833 SHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQHTGE 897
            .|.|.||||||:.|..|||......:|..|...|:|.:|:||..|.|::|...|..:||:.||||
Human   769 VHWRTHTGEKPYTCKECGKGCITLSQLTLHQRIHTGERPYKCEECGKAFRTNSDFTVHLRMHTGE 833

  Fly   898 CPFVCGTCGERFIQSSTLEKHRLMRRHFDEVE 929
            .|:.|..||:.|..||:|..|:  |.|..|.:
Human   834 KPYKCNECGKAFRSSSSLTVHQ--RIHQRETQ 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	13/64 (20%)
		C2H2 Zn finger	206..227	CDD:275368	6/20 (30%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		C2H2 Zn finger	401..422	CDD:275368	7/20 (35%)
		C2H2 Zn finger	431..447	CDD:275368	3/15 (20%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	490..511	CDD:275368	6/20 (30%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	638..659	CDD:275368	7/24 (29%)
		C2H2 Zn finger	668..690	CDD:275368	6/21 (29%)
		C2H2 Zn finger	698..715	CDD:275368	5/16 (31%)
		C2H2 Zn finger	753..774	CDD:275368	6/20 (30%)
		C2H2 Zn finger	790..810	CDD:275368	4/19 (21%)
		zf-H2C2_2	802..825	CDD:290200	10/22 (45%)
		COG5048	814..>886	CDD:227381	33/71 (46%)
		C2H2 Zn finger	818..838	CDD:275368	10/19 (53%)
		zf-H2C2_2	830..855	CDD:290200	13/24 (54%)
		C2H2 Zn finger	846..866	CDD:275368	6/19 (32%)
		zf-H2C2_2	859..883	CDD:290200	9/23 (39%)
		C2H2 Zn finger	874..894	CDD:275368	7/19 (37%)
		C2H2 Zn finger	902..924	CDD:275368	9/21 (43%)
ZNF624	NP_065838.2	KRAB	54..114	CDD:214630
		KRAB	54..93	CDD:279668
		C2H2 Zn finger	254..270	CDD:275368	3/20 (15%)
		COG5048	<268..463	CDD:227381	58/303 (19%)
		C2H2 Zn finger	278..298	CDD:275368	6/20 (30%)
		zf-H2C2_2	291..315	CDD:290200	9/25 (36%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		zf-H2C2_2	318..341	CDD:290200	6/22 (27%)
		C2H2 Zn finger	334..354	CDD:275368	2/19 (11%)
		zf-H2C2_2	346..371	CDD:290200	5/33 (15%)
		C2H2 Zn finger	362..381	CDD:275368	5/18 (28%)
		zf-H2C2_2	375..398	CDD:290200	7/22 (32%)
		zf-C2H2	388..410	CDD:278523	6/76 (8%)
		C2H2 Zn finger	390..410	CDD:275368	6/74 (8%)
		zf-H2C2_2	403..427	CDD:290200	9/83 (11%)
		COG5048	414..826	CDD:227381	137/501 (27%)
		C2H2 Zn finger	418..438	CDD:275368	7/20 (35%)
		zf-H2C2_2	430..455	CDD:290200	8/26 (31%)
		C2H2 Zn finger	446..466	CDD:275368	4/21 (19%)
		zf-H2C2_2	459..483	CDD:290200	5/25 (20%)
		C2H2 Zn finger	474..494	CDD:275368	6/19 (32%)
		zf-H2C2_2	486..511	CDD:290200	9/25 (36%)
		C2H2 Zn finger	502..522	CDD:275368	6/20 (30%)
		zf-H2C2_2	514..537	CDD:290200	7/24 (29%)
		C2H2 Zn finger	530..550	CDD:275368	5/19 (26%)
		zf-H2C2_2	543..565	CDD:290200	7/41 (17%)
		C2H2 Zn finger	558..578	CDD:275368	8/31 (26%)
		C2H2 Zn finger	586..606	CDD:275368	4/20 (20%)
		zf-H2C2_2	598..622	CDD:290200	7/29 (24%)
		C2H2 Zn finger	614..634	CDD:275368	7/24 (29%)
		zf-H2C2_2	626..651	CDD:290200	8/26 (31%)
		C2H2 Zn finger	642..662	CDD:275368	6/21 (29%)
		zf-H2C2_2	654..679	CDD:290200	6/29 (21%)
		C2H2 Zn finger	670..690	CDD:275368	7/33 (21%)
		zf-H2C2_2	683..707	CDD:290200	8/45 (18%)
		C2H2 Zn finger	698..718	CDD:275368	6/20 (30%)
		zf-H2C2_2	711..735	CDD:290200	10/32 (31%)
		C2H2 Zn finger	726..746	CDD:275368	4/19 (21%)
		zf-H2C2_2	738..763	CDD:290200	12/24 (50%)
		C2H2 Zn finger	754..774	CDD:275368	10/19 (53%)
		C2H2 Zn finger	782..802	CDD:275368	6/19 (32%)
		zf-H2C2_2	795..819	CDD:290200	9/23 (39%)
		C2H2 Zn finger	810..830	CDD:275368	7/19 (37%)
		zf-H2C2_2	822..847	CDD:290200	12/24 (50%)
		C2H2 Zn finger	838..858	CDD:275368	9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910