DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18476 and znf1059

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001121721.2	Gene:	znf1059 / 563440	ZFINID:	ZDB-GENE-030131-8437	Length:	390	Species:	Danio rerio

Alignment Length:	326	Identity:	101/326 - (30%)
Similarity:	147/326 - (45%)	Gaps:	55/326 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   610 ESGFELQLEDSETEDEMQPGVGS--RP-------VYICELCSVQCKRKFEMIQHQRTMHRFDKMP 665
            |..||.|.|.::.:..:.....|  ||       .:.|..|..:..||..:..|.| :|..:| |
Zfish    45 EKQFEKQQEITDEKPTLTEKTSSHGRPRNSKSACNFTCRQCGNRFSRKHNLQVHMR-IHSGEK-P 107

  Fly   666 HECDDC--IFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPT 728
            :.|..|  .| |.|.:::.|.|   ..:.||.::|.:|...|....||:.|         :...|
Zfish   108 YTCQQCGQCF-CTSGNLVVHMR---IHTGEKPYSCSQCGKSFKQISNLKVH---------MRTHT 159

  Fly   729 GDRHTQGTGDLEKDATEDGIPLLQCPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLC 793
            |:|.                  .:|..|.:.:........|:| :|        ..:..:.|..|
Zfish   160 GERP------------------YECQQCGQRFYTTGNFAQHMR-IH--------TGVGLYPCLQC 197

  Fly   794 GMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDK 858
            |.....:|.||.|||.||||:|:.|..|..:|.::|.|.:|.|:|||.:.|.||.|||.||:...
Zfish   198 GKSFHQSANLVAHMRIHTGERPYSCIQCGKSFKQNSNLEAHMRIHTGGRIFTCTQCGKSFAQKQD 262

  Fly   859 LKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHRLMRR 923
            |:.|:..|:|.||:.||.|.||:|....||.|:..||||.||.|..||:.|...::|..|  |..
Zfish   263 LEIHIRVHTGEKPYTCTECSKSFRYKSTLKHHMISHTGEKPFTCAQCGKSFTTKASLMNH--MNG 325

  Fly   924 H 924
            |
Zfish   326 H 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	401..422	CDD:275368
		C2H2 Zn finger	431..447	CDD:275368
		C2H2 Zn finger	461..481	CDD:275368
		C2H2 Zn finger	490..511	CDD:275368
		C2H2 Zn finger	520..540	CDD:275368
		C2H2 Zn finger	638..659	CDD:275368	6/20 (30%)
		C2H2 Zn finger	668..690	CDD:275368	7/23 (30%)
		C2H2 Zn finger	698..715	CDD:275368	5/16 (31%)
		C2H2 Zn finger	753..774	CDD:275368	4/20 (20%)
		C2H2 Zn finger	790..810	CDD:275368	9/19 (47%)
		zf-H2C2_2	802..825	CDD:290200	12/22 (55%)
		COG5048	814..>886	CDD:227381	31/71 (44%)
		C2H2 Zn finger	818..838	CDD:275368	7/19 (37%)
		zf-H2C2_2	830..855	CDD:290200	13/24 (54%)
		C2H2 Zn finger	846..866	CDD:275368	9/19 (47%)
		zf-H2C2_2	859..883	CDD:290200	11/23 (48%)
		C2H2 Zn finger	874..894	CDD:275368	9/19 (47%)
		C2H2 Zn finger	902..924	CDD:275368	7/21 (33%)
znf1059	NP_001121721.2	COG5048	<58..322	CDD:227381	93/305 (30%)
		C2H2 Zn finger	82..102	CDD:275368	6/20 (30%)
		zf-H2C2_2	94..117	CDD:290200	7/24 (29%)
		C2H2 Zn finger	110..130	CDD:275368	7/23 (30%)
		zf-H2C2_2	122..147	CDD:290200	7/27 (26%)
		C2H2 Zn finger	138..158	CDD:275368	6/28 (21%)
		zf-H2C2_2	150..175	CDD:290200	8/51 (16%)
		C2H2 Zn finger	166..186	CDD:275368	4/20 (20%)
		zf-H2C2_2	206..231	CDD:290200	13/24 (54%)
		C2H2 Zn finger	222..242	CDD:275368	7/19 (37%)
		zf-H2C2_2	234..259	CDD:290200	13/24 (54%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		zf-H2C2_2	262..287	CDD:290200	11/24 (46%)
		C2H2 Zn finger	278..298	CDD:275368	9/19 (47%)
		zf-H2C2_2	291..315	CDD:290200	13/23 (57%)
		C2H2 Zn finger	306..326	CDD:275368	7/21 (33%)
		C2H2 Zn finger	334..354	CDD:275368
		C2H2 Zn finger	362..382	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910