DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18476 and si:dkeyp-84f3.9

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_691447.5	Gene:	si:dkeyp-84f3.9 / 562992	ZFINID:	ZDB-GENE-131127-66	Length:	939	Species:	Danio rerio

Alignment Length:	879	Identity:	177/879 - (20%)
Similarity:	269/879 - (30%)	Gaps:	332/879 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 LETED---EDCGENDVTITCSELP---EPDETDMESKKSVDPLTMIETVKLEMEPRSVEKPAYDD 173
            :|.:|   |...:||.|:. .|.|   |..|::.|..|                    |.||.||
Zfish   197 VEMQDSLSETLNQNDETLD-DEDPSTEEQQESNSEQNK--------------------ETPAEDD 240

  Fly   174 PTSD--FEDEDSLDNLPLYNRIQKWKTGRKSVYKCHDCPRSFKRFDFLKRHEMRVHKPETRLYDC 236
            ...:  .|..::....|.:.|.:..|  .|.|.:|..|.|.|........| :|:|..| :.:.|
Zfish   241 NAKENSMEVTENKHGFPSFTRGRPRK--EKRVIRCEHCSRPFNHASAYIIH-LRIHTGE-KPFVC 301

  Fly   237 SLCIRKFSRSEALEAHLKIHRNSKRSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIAD 301
            ..|.:.|::...|.:|.|:||:..|     :|:                         ..||:.
Zfish   302 QDCGKAFAQLSNLRSHSKVHRSRSR-----KHR-------------------------NQNKVT- 335

  Fly   302 LRRHLEEHPDIVSLCGRPNMEPHELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQSG 366
                                           ..|...|.|:                ||
Zfish   336 -------------------------------TEKSADESQV----------------YS------ 347

  Fly   367 YEMDLDSSETDSDLDGDHDDQ--HKRRK-----KSRKAT-------------------------- 398
                .|..|||.     |.:|  .|||:     |.:..|
Zfish   348 ----TDKKETDF-----HSNQITSKRRRGRGKGKGKPQTCPICAKVFCYKSVLKIHLRIHSGEKP 403

  Fly   399 YSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRHH---NESQCRNAQKR-- 458
            |||::|.:.|.:......|:|.  .||..|.:|.:|...|..|..|:.|   .:::..|..|.
Zfish   404 YSCKVCGKSFTQACTARVHERV--HWSIRPFLCTKCGKGFSQLGPLKLHTCEGKTRMHNTVKEME 466

  Fly   459 ------FLCHKCPLRFRWKHNLKTHFREHRITNQTFECSECKRVFDKKKSLTVHLLSVHAEESKL 517
                  |.||.|...|..:...:.|.:.|:.| |.:.|..||:.|.....|..|  |.|....:|
Zfish   467 TDGVVSFRCHLCKTCFSTRDEYELHVQGHKDT-QRYSCDRCKQTFSLLSELHTH--SKHCGAIRL 528

  Fly   518 IPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAATSR----PNGAKRITCRMCNLHFERI 578
                 ...||..:....:...:..:.....|...:...:..:    |...||     |:|
Zfish   529 -----AKSKFSGYSPPHRSQPKSPMNRRTPPRVRSPAKSPQKEIFSPRKLKR-----CSL----- 578

  Fly   579 VDLRAHIQLELKLSLSLHQSYDSPHN-YSITNESGFELQLEDSETEDEMQPGVGSRPVYICELCS 642
                    |.....:......|.|:| ||:                        |:|:
Zfish   579 --------LACPPQILAASDSDFPNNLYSV------------------------SQPI------- 604

  Fly   643 VQCKRKFEMIQHQRTMHRFDKMPHECDDC--IFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYKF 705
               |..:.:.|...|.|:.|...:.|..|  ||:.|.:
Zfish   605 ---KSSYFVSQLNSTHHKADPRSYFCPRCGRIFRHVGR--------------------------- 639

  Fly   706 MWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPHCDRTYQ------MKS 764
                 |..|:|              .|::|     |:.|        |.:|:|.::      :..
Zfish   640 -----LRAHML--------------THSRG-----KNFT--------CVYCNRVFKTWNKFWIHQ 672

  Fly   765 RLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHS 829
            ||:..||.              ||.|..||...|...:...|:::|.......|..|...|....
Zfish   673 RLHRQIRG--------------RFFCPKCGRGFRFVESYNEHVQKHPELNAHACPFCTRTFSNAQ 723

  Fly   830 ELASHR-RMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQ 893
            :|.:|: :.|....||.|..|||.|..:..||||.:.|..:.|.:..|       ..||     |
Zfish   724 KLRNHQEKWHHSTMPFVCEYCGKGFESATILKRHKVVHCTIDPIETLY-------NADL-----Q 776

  Fly   894 HTGECPFVCGTCGERFIQSSTLEKHRLMRRHFDE 927
            .||. |:.||.|...|.....|..|:|..:..|:
Zfish   777 STGH-PYECGACSACFGNLDLLFHHQLQHKAADK 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368	6/20 (30%)
		C2H2 Zn finger	236..256	CDD:275368	6/19 (32%)
		C2H2 Zn finger	401..422	CDD:275368	5/20 (25%)
		C2H2 Zn finger	431..447	CDD:275368	5/15 (33%)
		C2H2 Zn finger	461..481	CDD:275368	5/19 (26%)
		C2H2 Zn finger	490..511	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	2/19 (11%)
		C2H2 Zn finger	638..659	CDD:275368	3/20 (15%)
		C2H2 Zn finger	668..690	CDD:275368	5/23 (22%)
		C2H2 Zn finger	698..715	CDD:275368	1/16 (6%)
		C2H2 Zn finger	753..774	CDD:275368	7/26 (27%)
		C2H2 Zn finger	790..810	CDD:275368	5/19 (26%)
		zf-H2C2_2	802..825	CDD:290200	4/22 (18%)
		COG5048	814..>886	CDD:227381	20/72 (28%)
		C2H2 Zn finger	818..838	CDD:275368	5/20 (25%)
		zf-H2C2_2	830..855	CDD:290200	10/25 (40%)
		C2H2 Zn finger	846..866	CDD:275368	9/19 (47%)
		zf-H2C2_2	859..883	CDD:290200	7/23 (30%)
		C2H2 Zn finger	874..894	CDD:275368	3/19 (16%)
		C2H2 Zn finger	902..924	CDD:275368	7/21 (33%)
si:dkeyp-84f3.9	XP_691447.5	C2H2 Zn finger	273..293	CDD:275368	6/20 (30%)
		zf-H2C2_2	289..310	CDD:290200	7/22 (32%)
		C2H2 Zn finger	378..398	CDD:275368	0/19 (0%)
		zf-H2C2_2	391..415	CDD:290200	5/23 (22%)
		C2H2 Zn finger	406..426	CDD:275368	5/21 (24%)
		C2H2 Zn finger	434..450	CDD:275368	5/15 (33%)
		C2H2 Zn finger	627..647	CDD:275368	8/65 (12%)
		C2H2 Zn finger	655..675	CDD:275368	4/19 (21%)
		C2H2 Zn finger	684..704	CDD:275368	5/19 (26%)
		LIM	712..764	CDD:295319	18/51 (35%)
		C2H2 Zn finger	712..733	CDD:275368	5/20 (25%)
		C2H2 Zn finger	741..761	CDD:275368	9/19 (47%)
		C2H2 Zn finger	784..804	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100