DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and si:ch211-119o8.6

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001108212.1	Gene:	si:ch211-119o8.6 / 556659	ZFINID:	ZDB-GENE-070912-17	Length:	735	Species:	Danio rerio

Alignment Length:	933	Identity:	203/933 - (21%)
Similarity:	338/933 - (36%)	Gaps:	286/933 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 CLCSGC-------TKKLMGAYCYVKQAMAANELLMKHLKNGAAPTSTDCLQEAPMELCAEQHVEV 113
            |||..|       .|.|....| :|:...:  :|:.||......:..:..|::..:.....::|.
Zfish    29 CLCKNCLQSYWELNKSLECPVC-LKETRCS--VLLHHLSISRFASEGEFSQDSNFKPLHVGNLES 90

  Fly   114 KLETEDEDCGENDVTITCSELP----EPDETD-----MESK-----KSVDPLTMIETVKLEMEPR 164
            :::.|     |..::...|.:|    |.|.|.     ||:|     .|:|.|....|::   :..
Zfish    91 EMQLE-----ETTISQVMSTIPRIKTEEDMTTIVQMLMETKYEPVETSIDDLIYTPTIE---DIS 147

  Fly   165 SVEKPAYDDPTSDFEDEDSLDNLPLYNRIQ------------------KWKTGRKSVYK--CHDC 209
            ||::    :|:::..:|:...:|.:::.:.                  ...|..:|:..  |..|
Zfish   148 SVKR----EPSNEVSNEEIHRDLMIHDTVPTSSSVLTEPNDSGEPPHLSTTTTCRSLRSNLCLKC 208

  Fly   210 PRSFKRFDFLKRHEMRVH---KPETRLYDCSLCIRKFSRSEALEAHLKIHRNSKRSANISEHKKA 271
            .:||:|...|:.|| :||   ||    :.||.|.:.:.....|..|.::|.
Zfish   209 GKSFERKSDLRAHE-KVHSLQKP----HQCSTCGKSYVDRHELSMHERLHT-------------- 254

  Fly   272 KAVDLNLCKPHGYKLIECMICQSQYNKIADLRRHLEEHPDIVSLCGRPNMEPHELAELFYPDSKD 336
                       |.||.:|..|:.::.:.:.|:.||..|
Zfish   255 -----------GEKLFDCSYCKKKFVRESALKYHLRSH--------------------------- 281

  Fly   337 LSEEQLINLIRKDLAAGIYQRFYSITNQSGYEMDLDSSETDSDLDGDHDDQHKRRKKSRKATYSC 401
                                                                     :.:..:||
Zfish   282 ---------------------------------------------------------TGEKPFSC 289

  Fly   402 ELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRHHNESQCRNAQKRFLCHKCPL 466
            ..|.:.|.|:..|..|.|.  .....||.|..|...|.:...:|.|..:  ...::.|.|.:|..
Zfish   290 SQCGKSFSRRSTLNTHLRL--HMGPLPHQCDHCGKLFNTAAAMRAHRAT--HTGERPFPCPQCDK 350

  Fly   467 RFRWKHNLKTHFREHRITNQTFECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHD 531
            :|.:|..|:.|...| ..|:.|:||.|.:.|.:|:...|| .::| ::.:...|.:|...|.|..
Zfish   351 KFIFKAELEVHLDGH-AGNKPFKCSVCGKGFLRKQECNVH-QTIH-QDKRSFHCTYCDNSFKRLS 412

  Fly   532 YLVKHLKRHGLKE-HDIPLAETLIAATSRPN----------GAKRITCRMCNLHFERIVDLRAHI 585
            :|..|||.|..:. |.....|   .:...||          |.|..:|..|...|....|...|:
Zfish   413 HLTSHLKIHYPESPHKCTYCE---KSFKHPNSLKLHERLHTGEKPYSCEHCGKRFPSSGDRTRHL 474

  Fly   586 QLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSETEDEMQPGVGSRPVYICELCSVQCKRKFE 650
            .:..::     :||..|                                         :|.|:|.
Zfish   475 AVHSEV-----KSYKCP-----------------------------------------KCDRRFR 493

  Fly   651 M---IQHQRTMHRFDKMPHECDDCIFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYKFMWPENLE 712
            .   :|..:.||..:: |..|..|.......:.:..|  ....:.|:.::|.:|...|.....|:
Zfish   494 FKNSLQSHQVMHTGER-PFHCKKCDRDFARLANLKAH--SVVHTEERSYSCSQCGQAFKCSSTLK 555

  Fly   713 QHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPHCDRTYQMKSRLNNHIRDVHING 777
            .|:::..||:                           ||.|..|.:|:.....|..| :|:|
Zfish   556 SHMIIHSSKT---------------------------LLDCTTCGKTFTRHDTLKRH-QDIH--- 589

  Fly   778 DRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTG-EKPFKCDLCEMAFPRHSELASHRRM-HTG 840
                 ..||.:.|:.||....||:.|..||..|:| :|.:.||.||.:|...|.|..||:| |:.
Zfish   590 -----AGIKVYKCTDCGKCLSSASCLKLHMEGHSGNKKMYYCDECEKSFSSMSYLQKHRQMAHSD 649

  Fly   841 EKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQHTGECPFVCGTC 905
            ||||.|..||:.|....||..|.|.|||...|.||.|.|.:.:.:.|:.|::.|:.|.|:.|..|
Zfish   650 EKPFVCFECGESFNSDGKLVTHQLQHSGRMDHACTECGKKFARKETLRRHVKAHSEERPYQCSDC 714

  Fly   906 GERFIQSSTLEKHRLMRRHFDEV 928
            |:.|.:|..|::|:|:  |.:.|
Zfish   715 GKGFKRSDQLKQHKLI--HSERV 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	9/34 (26%)
		C2H2 Zn finger	206..227	CDD:275368	8/20 (40%)
		C2H2 Zn finger	236..256	CDD:275368	5/19 (26%)
		C2H2 Zn finger	401..422	CDD:275368	7/20 (35%)
		C2H2 Zn finger	431..447	CDD:275368	4/15 (27%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	490..511	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	8/19 (42%)
		C2H2 Zn finger	638..659	CDD:275368	4/23 (17%)
		C2H2 Zn finger	668..690	CDD:275368	3/21 (14%)
		C2H2 Zn finger	698..715	CDD:275368	4/16 (25%)
		C2H2 Zn finger	753..774	CDD:275368	6/20 (30%)
		C2H2 Zn finger	790..810	CDD:275368	8/19 (42%)
		zf-H2C2_2	802..825	CDD:290200	10/23 (43%)
		COG5048	814..>886	CDD:227381	32/72 (44%)
		C2H2 Zn finger	818..838	CDD:275368	10/20 (50%)
		zf-H2C2_2	830..855	CDD:290200	13/25 (52%)
		C2H2 Zn finger	846..866	CDD:275368	8/19 (42%)
		zf-H2C2_2	859..883	CDD:290200	11/23 (48%)
		C2H2 Zn finger	874..894	CDD:275368	6/19 (32%)
		C2H2 Zn finger	902..924	CDD:275368	8/21 (38%)
si:ch211-119o8.6	NP_001108212.1	COG5048	201..587	CDD:227381	108/586 (18%)
		C2H2 Zn finger	205..225	CDD:275370	8/20 (40%)
		C2H2 Zn finger	233..253	CDD:275368	5/19 (26%)
		C2H2 Zn finger	261..281	CDD:275368	5/19 (26%)
		zf-H2C2_2	273..298	CDD:290200	8/108 (7%)
		C2H2 Zn finger	289..309	CDD:275368	7/21 (33%)
		C2H2 Zn finger	317..337	CDD:275368	5/21 (24%)
		C2H2 Zn finger	345..362	CDD:275368	5/16 (31%)
		C2H2 Zn finger	373..393	CDD:275368	7/20 (35%)
		C2H2 Zn finger	401..421	CDD:275368	8/19 (42%)
		C2H2 Zn finger	429..449	CDD:275368	3/22 (14%)
		C2H2 Zn finger	457..477	CDD:275368	5/19 (26%)
		C2H2 Zn finger	485..505	CDD:275368	5/60 (8%)
		C2H2 Zn finger	513..533	CDD:275368	3/21 (14%)
		C2H2 Zn finger	541..561	CDD:275368	5/19 (26%)
		C2H2 Zn finger	569..589	CDD:275368	6/20 (30%)
		C2H2 Zn finger	597..614	CDD:275368	6/16 (38%)
		C2H2 Zn finger	626..647	CDD:275368	10/20 (50%)
		C2H2 Zn finger	655..675	CDD:275368	8/19 (42%)
		C2H2 Zn finger	683..703	CDD:275368	6/19 (32%)
		C2H2 Zn finger	711..731	CDD:275368	8/21 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45252
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010