Protein Alignment CG18476 and ZNF107

DIOPT Version :10

• Sequence 1: NP_731615.1
• Gene: CG18476 / 41404
• FlyBaseID: FBgn0037931
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: NP_001374954.1
• Gene: ZNF107 / 51427
• HGNCID: 12887
• Length: 896
• Species: Homo sapiens
• Alignment Length: 946
• Identity: 219/946 - (23%)
• Similarity: 343/946 - (36%)
• Gaps: 280/946 - (29%)

  Fly    14 DTDNLLKLATPSKKYPDKLLSEILCELTEIN---LDATGSQKFPQCLCSGCTKKLMGAYCYVKQA 75
            :|.|....|||||.:......::..:.:..|   ...||::.|.   |..|:|    ::|.:.|
Human   175 NTVNQCLTATPSKIFQCNKYVKVFDKFSNSNRYKRRHTGNKHFK---CKECSK----SFCVLSQ- 231

  Fly    76 MAANELLMKHLKNGAAPTSTDCLQEAPMELCAE---------QHVEVKLETED---EDCGE---- 124
                  |.:|.:......|..|      |.|.:         :|..:....:.   |:||:
Human   232 ------LTQHRRIHTRVNSYKC------EECGKAFNWFSTLTKHKRIHTGEKPYKCEECGKAFNQ 284

  Fly   125 -NDVT----ITCSELPEPDETDMESKKSVDPLTMIETVKLEMEPRSVEKP-AYDDPTSDFEDEDS 183
             :.:|    |...|.|...|...::.|....||:.:.:      .:.||| .|::....|.....
Human   285 SSQLTRHKIIHTEEKPNKCEECGKAFKQASHLTIHKII------HTGEKPYKYEECGKVFSQSSH 343

  Fly   184 LDNLPLYNRIQKWKTGRKSVYKCHDCPRSFKRFDFLKRHEMRVHKPETRLYDCSLCIRKFSRSEA 248
            |....:.:      || :::|||.:|.::|..|..|..|: |:|..| :.|.|..|.|.|:.|..
Human   344 LTTQKILH------TG-ENLYKCKECGKAFNLFSNLTNHK-RIHAGE-KPYKCKECGRAFNISSN 399

  Fly   249 LEAHLKIHRNSKRSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIADLRRH----LEEH 309
            |....|||.                         |.||.:|..|...:|:...|..|    :||.
Human   400 LNKQEKIHT-------------------------GGKLNKCEECDKAFNRSLKLTAHKKILMEEK 439

  Fly   310 PDIVSLCGRPNMEPHELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQSGYEMDLDSS 374
            |.....||:                                   ::.:|.::|
Human   440 PYKCEECGK-----------------------------------VFNQFSTLT------------ 457

  Fly   375 ETDSDLDGDHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFV 439
                        :||......| .|.|:.|.:.|.:...|.:| ::.|: ::..:.|..|...|.
Human   458 ------------RHKIIHTGEK-PYKCKECGKAFNQSSNLTEH-KKIHT-AEKSYKCEECGKAFN 507

  Fly   440 SLQLLRHHNESQCRNAQKRFLCHKCPLRFRWKHNLKTHFREHRITNQTFECSECKRVFDKKKSLT 504
            ....|.:|.  :..:.:|.:.|.:|...|.....|..|.:.| ...:.::|.||.|.|.:..:||
Human   508 QHSNLINHR--KIYSGEKPYKCEECGKAFNRSSTLTRHKKIH-TGEKPYKCEECDRAFSQSSNLT 569

  Fly   505 VHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAATSRPNGAKRITCR 569
            .| ..:|..| |...|:.|.:.|.|...|.||.:.|                    .|.|...|.
Human   570 EH-KKIHTGE-KPYKCEECGKAFNRFSTLTKHKRIH--------------------TGEKPYKCE 612

  Fly   570 MCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSETEDEMQPGVGSRP 634
            .|...|.:...|..|..:..|..|:.
Human   613 ECGKAFNQSYQLTRHKIVHTKEKLNK--------------------------------------- 638

  Fly   635 VYICELCSVQCKRKFEMIQHQRTMHRF---DKMPHECDDCIFKCVSKSIMDHHR---QGQCSSTE 693
               ||    :..:.|:...| ||:|:.   .:.|::|:            :|.:   |....:|:
Human   639 ---CE----EFGKAFKQSSH-RTIHKIIHTGEKPYKCE------------EHGKVFNQSSNLTTQ 683

  Fly   694 KKHACGKCSYKFMWPENLEQHILLQHSKSSVSNP----TGDR-HTQGTGDLEKDATEDGIPLLQC 753
            |....|:..|||      |:|....:..|:::|.    ||:: |                   :|
Human   684 KIIHTGENLYKF------EEHGKAFNLFSNITNHKIIYTGEKPH-------------------KC 723

  Fly   754 PHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKC 818
            ..|.:.|...|.|..|.| :| .|:       |.:.|:.||.....::.|..|...||||||:||
Human   724 EECGKAYNRFSNLTIHKR-IH-TGE-------KPYQCAECGKAFNCSSTLNRHKIIHTGEKPYKC 779

  Fly   819 DLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQ 883
            ..|..||...|.|.:|:::||||||:.|..|||.|.:|..|..|...|:..||:||..|.||:.|
Human   780 KECGKAFNLSSTLTAHKKIHTGEKPYKCEECGKAFNQSSNLTTHKKIHTSEKPYKCEECGKSFNQ 844

  Fly   884 AKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHR 919
            ...|.:|...||||.|:.||..|..|..||.|..|:
Human   845 FSSLNIHKIIHTGEKPYKCGDYGRAFNLSSNLTTHK 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	C2H2 Zn finger	206..227	CDD:275368	7/20 (35%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		C2H2 Zn finger	401..422	CDD:275368	5/20 (25%)
		C2H2 Zn finger	431..447	CDD:275368	4/15 (27%)
		C2H2 Zn finger	461..481	CDD:275368	5/19 (26%)
		C2H2 Zn finger	490..511	CDD:275368	8/20 (40%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	638..659	CDD:275368	6/20 (30%)
		C2H2 Zn finger	668..690	CDD:275368	3/24 (13%)
		C2H2 Zn finger	698..715	CDD:275368	5/16 (31%)
		C2H2 Zn finger	753..774	CDD:275368	7/20 (35%)
		C2H2 Zn finger	790..810	CDD:275368	5/19 (26%)
		COG5048	814..>886	CDD:227381	33/71 (46%)
		C2H2 Zn finger	818..838	CDD:275368	7/19 (37%)
		C2H2 Zn finger	846..866	CDD:275368	8/19 (42%)
		C2H2 Zn finger	874..894	CDD:275368	7/19 (37%)
		C2H2 Zn finger	902..924	CDD:275368	8/18 (44%)
ZNF107	NP_001374954.1	KRAB	48..108	CDD:214630
		C2H2 Zn finger	191..211	CDD:275368	1/19 (5%)
		C2H2 Zn finger	219..239	CDD:275368	7/30 (23%)
		COG5048	243..621	CDD:227381	106/510 (21%)
		C2H2 Zn finger	247..267	CDD:275368	4/25 (16%)
		C2H2 Zn finger	275..295	CDD:275368	4/19 (21%)
		C2H2 Zn finger	303..323	CDD:275368	4/25 (16%)
		C2H2 Zn finger	331..351	CDD:275368	3/19 (16%)
		C2H2 Zn finger	359..379	CDD:275368	7/20 (35%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		C2H2 Zn finger	415..435	CDD:275368	5/19 (26%)
		C2H2 Zn finger	443..463	CDD:275368	6/78 (8%)
		C2H2 Zn finger	471..491	CDD:275368	5/20 (25%)
		C2H2 Zn finger	499..519	CDD:275368	5/21 (24%)
		C2H2 Zn finger	527..547	CDD:275368	5/19 (26%)
		COG5048	551..>863	CDD:227381	111/426 (26%)
		C2H2 Zn finger	555..575	CDD:275368	8/20 (40%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		C2H2 Zn finger	611..631	CDD:275368	5/19 (26%)
		C2H2 Zn finger	639..659	CDD:275368	7/24 (29%)
		C2H2 Zn finger	699..715	CDD:275368	2/15 (13%)
		C2H2 Zn finger	723..743	CDD:275368	7/20 (35%)
		C2H2 Zn finger	751..771	CDD:275368	5/19 (26%)
		C2H2 Zn finger	779..799	CDD:275368	7/19 (37%)
		C2H2 Zn finger	807..827	CDD:275368	8/19 (42%)
		C2H2 Zn finger	835..855	CDD:275368	7/19 (37%)
		C2H2 Zn finger	863..883	CDD:275368	8/18 (44%)