DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18476 and Zfp133

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001019484.2	Gene:	Zfp133 / 499900	RGDID:	1566283	Length:	544	Species:	Rattus norvegicus

Alignment Length:	758	Identity:	169/758 - (22%)
Similarity:	253/758 - (33%)	Gaps:	259/758 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 GRKSVYKCHDCPRSFKRFDFLKRHEMRVHKPETR-LYD----------CSLCIRKFSRSE---AL 249
            ||.:.:|.|...|.. ..|| .:.|..:..|..| ||.          .||.| .||:.:   .|
  Rat    12 GRGACWKVHMAFRDV-AVDF-SQEEWSLLSPAQRSLYREVMLENYSNLVSLGI-PFSKPKLITQL 73

  Fly   250 EAHLKIHRNSKRSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQY-NKIADLRRHLEEHPDIV 313
            |...:..|..::...::...:||   |.||..|        :|.... |:.:.::..|..|..::
  Rat    74 EQGKETWREERKCPQVACPAQAK---LELCPGH--------VCPPDLTNQKSPVQHVLSHHAPLI 127

  Fly   314 SLCGRPNMEPHELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQSGYEMDLDSSETDS 378
            ..|                    |..|..::  |.|...|..::.:..::::...   |.||
  Rat   128 FTC--------------------LCAESHVD--RGDSCQGALEKQHQASDKNSCR---DKSE--- 164

  Fly   379 DLDGDHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQL 443
              .|:.:.......:::|.                                          ||..
  Rat   165 --GGERESARPSSGRTKKG------------------------------------------SLGA 185

  Fly   444 LRHHNESQCRNAQKRFLCHKCPLRFRWKHNLKTHFREHRITNQ--------------TFECSECK 494
            |....:.|..|:         |...||. .::|...:.|.|.:              |..|.||.
  Rat   186 LSRPPQGQPVNS---------PNGIRWV-EMETSPAQARSTEEPEKLLKGIEILEFGTVNCEECG 240

  Fly   495 RVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAATSR 559
            ..|.|..:|..| ..:|:.|...: |..|.:.|.....|.:|.|.|
  Rat   241 LGFSKMTNLLSH-QRIHSGEKPYV-CGVCEKGFSLKKSLARHQKAH------------------- 284

  Fly   560 PNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSETED 624
             :|.|.|.|:.|...|.|            |.:|.:|:...|
  Rat   285 -SGEKPIVCKECWRGFSR------------KSTLIIHERTHS----------------------- 313

  Fly   625 EMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCVSKSIMDHHRQGQC 689
                  |.:| |:|..|.....:|..:|.||||
  Rat   314 ------GEKP-YMCSECGRGFSQKSNLIIHQRT-------------------------------- 339

  Fly   690 SSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCP 754
            .|.||.:.|.:|...|.     ::..:::|..:.:...|                      ..|.
  Rat   340 HSGEKPYVCRECGKGFS-----QKSAVVRHESTHLEEKT----------------------FLCS 377

  Fly   755 HCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCD 819
            .|...:..:|...:|.| .| :|:       |.:.|..||...|....||.|.|.|:.|||:.|.
  Rat   378 DCGLGFSDRSNFISHQR-TH-SGE-------KPYACKECGQCFRQRTTLVNHQRTHSKEKPYVCG 433

  Fly   820 LCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQA 884
            :|..:|.::|.|.|||||||||||:.|.|||:.|:....|.||...|||.||..|..|.:.:.|.
  Rat   434 ICGHSFSQNSTLISHRRMHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQQ 498

  Fly   885 KDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHRLMRRHFDE 927
            .:|..|.:.|:||.|.||..||..|.|.|.|..|:  |.|..|
  Rat   499 SNLIRHQRTHSGEKPIVCEECGRGFSQKSNLIAHQ--RTHSGE 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368	5/20 (25%)
		C2H2 Zn finger	236..256	CDD:275368	7/22 (32%)
		C2H2 Zn finger	401..422	CDD:275368	0/20 (0%)
		C2H2 Zn finger	431..447	CDD:275368	3/15 (20%)
		C2H2 Zn finger	461..481	CDD:275368	4/19 (21%)
		C2H2 Zn finger	490..511	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..659	CDD:275368	8/20 (40%)
		C2H2 Zn finger	668..690	CDD:275368	0/21 (0%)
		C2H2 Zn finger	698..715	CDD:275368	3/16 (19%)
		C2H2 Zn finger	753..774	CDD:275368	5/20 (25%)
		C2H2 Zn finger	790..810	CDD:275368	8/19 (42%)
		zf-H2C2_2	802..825	CDD:290200	10/22 (45%)
		COG5048	814..>886	CDD:227381	34/71 (48%)
		C2H2 Zn finger	818..838	CDD:275368	9/19 (47%)
		zf-H2C2_2	830..855	CDD:290200	17/24 (71%)
		C2H2 Zn finger	846..866	CDD:275368	8/19 (42%)
		zf-H2C2_2	859..883	CDD:290200	10/23 (43%)
		C2H2 Zn finger	874..894	CDD:275368	5/19 (26%)
		C2H2 Zn finger	902..924	CDD:275368	9/21 (43%)
Zfp133	NP_001019484.2	KRAB	21..80	CDD:214630	15/61 (25%)
		KRAB	21..60	CDD:279668	8/40 (20%)
		COG5048	235..>530	CDD:227381	111/426 (26%)
		C2H2 Zn finger	236..256	CDD:275368	7/20 (35%)
		zf-H2C2_2	248..272	CDD:290200	6/25 (24%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		C2H2 Zn finger	292..312	CDD:275368	7/31 (23%)
		zf-H2C2_2	305..329	CDD:290200	8/53 (15%)
		zf-C2H2	318..340	CDD:278523	9/53 (17%)
		C2H2 Zn finger	320..340	CDD:275368	8/51 (16%)
		zf-H2C2_2	332..357	CDD:290200	11/61 (18%)
		C2H2 Zn finger	348..368	CDD:275368	4/24 (17%)
		C2H2 Zn finger	376..396	CDD:275368	5/20 (25%)
		zf-H2C2_2	388..413	CDD:290200	8/33 (24%)
		C2H2 Zn finger	404..424	CDD:275368	8/19 (42%)
		zf-H2C2_2	417..441	CDD:290200	11/23 (48%)
		C2H2 Zn finger	432..452	CDD:275368	9/19 (47%)
		zf-H2C2_2	445..468	CDD:290200	16/22 (73%)
		C2H2 Zn finger	460..480	CDD:275368	8/19 (42%)
		zf-H2C2_2	472..497	CDD:290200	10/24 (42%)
		zf-C2H2	487..508	CDD:278523	5/20 (25%)
		C2H2 Zn finger	488..508	CDD:275368	5/19 (26%)
		zf-H2C2_2	500..525	CDD:290200	11/24 (46%)
		C2H2 Zn finger	516..536	CDD:275368	9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000