DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and Zfp62

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_006246250.1	Gene:	Zfp62 / 497894	RGDID:	1560191	Length:	924	Species:	Rattus norvegicus

Alignment Length:	882	Identity:	223/882 - (25%)
Similarity:	341/882 - (38%)	Gaps:	225/882 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 YVKQAMAANELLMKHLKNGAAPTSTDCLQEAP-MELCAEQH------------VEVKLE------ 116
            ::|.:|...:...|:..|.:|.:      :.| :|:..:.|            ||.:||
  Rat     3 HLKTSMEDEDSAKKNENNSSADS------QCPNVEIFHKDHMQNSNIDDTFGWVEKQLERPKWKI 61

  Fly   117 -TEDE-------DCGENDVTITCSELPEPDETDMES-KKSVDPLTMIETVKLEMEPRSVEKPAYD 172
             .||:       |..:|...:   ::.:.|||..:| ..|.|  ||.:||  ..||:..|:..:.
  Rat    62 MKEDKSSIREKIDKPKNTANV---KIEQDDETSEKSFYSSTD--TMHQTV--PTEPKCTEQGEHT 119

  Fly   173 DPTSDFEDEDSLDNLPLYNRIQKWKTGRKSVYKCHDCPRSFKRFDFLKRHEMRVHKPETRLYDCS 237
            :..:     .||...|..|     ....|..:||.:|.:|||....|.:|:: :|..|.| |:|.
  Rat   120 ENVN-----GSLHPTPQQN-----SAADKKSHKCDECGKSFKYNSRLVQHKI-MHTGEKR-YECD 172

  Fly   238 LCIRKFSRSEALEAHLKIHRNSKRSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIADL 302
            .|...|..|.:|..|.:||.                         |.|..:|..|...|...:.|
  Rat   173 DCRGTFRSSSSLRVHKRIHT-------------------------GEKPYKCDECGKAYMSYSSL 212

  Fly   303 RRHLEEHPDIVSLCGRPNMEPHELAELF-YPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQSG 366
            ..|...|      .|..|.:..|..:.| |  |..|.:.:.|:...|....|...:  :..|.||
  Rat   213 INHKSTH------SGEKNCKCDECGKSFNY--SSVLDQHKRIHTGEKPYECGECGK--AFRNSSG 267

  Fly   367 YEMDLDSSETDSDLDGDHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVC 431
            ..:                  |||.....| .|.|::|.:.|.....|..|:| .|: .:.|:.|
  Rat   268 LRV------------------HKRIHTGEK-PYECDICGKTFSNSSGLRVHKR-IHT-GEKPYEC 311

  Fly   432 GRCDGRFVSLQLLRHHNESQCRNAQKRFLCHKCPLRFRWKHNLKTHFREHRITN---QTFECSEC 493
            ..|...|::.:.|.:|  .......|.:.|.:|...|    |..:...:|::.:   :.:||.||
  Rat   312 DECGKAFITCRTLLNH--KSIHFGDKPYKCDECEKSF----NYSSLLIQHKVIHTGEKPYECDEC 370

  Fly   494 KRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRH-GLKEHDIPLAETLIAAT 557
            .:.|.....|.|| ..:|..| |...|..|.:.|.....|..|...| |.|.|:
  Rat   371 GKAFRNSSGLIVH-KRIHTGE-KPYKCDICGKAFSYSSGLAVHKSIHPGKKAHE----------- 422

  Fly   558 SRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSET 622
                      |:.|...|                      ||:|           ..||.:...|
  Rat   423 ----------CKDCGKSF----------------------SYNS-----------LLLQHKTIHT 444

  Fly   623 EDEMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCVSKSIMDHHRQG 687
                    |.|| |:|::|....:....:..|:| :|..:| |::||.|....:|:|.:.:|:..
  Rat   445 --------GERP-YVCDVCGKTFRNNSGLKVHRR-LHTGEK-PYKCDVCGKAYISRSSLKNHKGI 498

  Fly   688 QCSSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQ 752
            ...  ||.:.|..|...|.:...||||..: |::   ..|.|
  Rat   499 HLG--EKPYKCSYCEKSFNYSSALEQHKRI-HTR---EKPFG----------------------- 534

  Fly   753 CPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFK 817
            |..|.:.::..|.|..|.| :| .|:|..|       |..||....|.::|:.|...|.||||||
  Rat   535 CDECGKAFRNNSGLKVHKR-IH-TGERPYK-------CEECGKAYISLSSLINHKSVHPGEKPFK 590

  Fly   818 CDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYR 882
            ||.||.||..:..|.:|:::|.||||:.|.||.|.|..:..|.:|...|:..||.:|..|||.:|
  Rat   591 CDECEKAFITYRTLLNHKKIHLGEKPYKCDVCEKSFNYTSLLSQHKRVHTREKPFECDRCEKVFR 655

  Fly   883 QAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHR 919
            ....||:|.:.||||.|:.|..||:.:|..|:|..|:
  Rat   656 NNSSLKVHKRIHTGEKPYECDICGKAYISHSSLINHK 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	2/12 (17%)
		C2H2 Zn finger	206..227	CDD:275368	7/20 (35%)
		C2H2 Zn finger	236..256	CDD:275368	6/19 (32%)
		C2H2 Zn finger	401..422	CDD:275368	6/20 (30%)
		C2H2 Zn finger	431..447	CDD:275368	4/15 (27%)
		C2H2 Zn finger	461..481	CDD:275368	4/19 (21%)
		C2H2 Zn finger	490..511	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	638..659	CDD:275368	4/20 (20%)
		C2H2 Zn finger	668..690	CDD:275368	6/21 (29%)
		C2H2 Zn finger	698..715	CDD:275368	6/16 (38%)
		C2H2 Zn finger	753..774	CDD:275368	6/20 (30%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		zf-H2C2_2	802..825	CDD:290200	13/22 (59%)
		COG5048	814..>886	CDD:227381	32/71 (45%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	12/24 (50%)
		C2H2 Zn finger	846..866	CDD:275368	7/19 (37%)
		zf-H2C2_2	859..883	CDD:290200	9/23 (39%)
		C2H2 Zn finger	874..894	CDD:275368	8/19 (42%)
		C2H2 Zn finger	902..924	CDD:275368	7/18 (39%)
Zfp62	XP_006246250.1	COG5048	125..552	CDD:227381	132/591 (22%)
		C2H2 Zn finger	143..163	CDD:275368	7/20 (35%)
		C2H2 Zn finger	171..191	CDD:275368	6/19 (32%)
		C2H2 Zn finger	199..219	CDD:275368	5/19 (26%)
		C2H2 Zn finger	227..247	CDD:275368	5/21 (24%)
		C2H2 Zn finger	255..275	CDD:275368	7/39 (18%)
		C2H2 Zn finger	283..303	CDD:275368	6/20 (30%)
		C2H2 Zn finger	311..331	CDD:275368	5/21 (24%)
		C2H2 Zn finger	339..359	CDD:275368	5/23 (22%)
		C2H2 Zn finger	367..387	CDD:275368	7/20 (35%)
		SFP1	<389..468	CDD:227516	26/142 (18%)
		C2H2 Zn finger	395..415	CDD:275368	5/19 (26%)
		C2H2 Zn finger	423..443	CDD:275368	8/52 (15%)
		COG5048	447..860	CDD:227381	94/287 (33%)
		C2H2 Zn finger	451..471	CDD:275368	4/20 (20%)
		C2H2 Zn finger	479..499	CDD:275368	6/19 (32%)
		C2H2 Zn finger	507..527	CDD:275368	7/20 (35%)
		C2H2 Zn finger	535..555	CDD:275368	6/20 (30%)
		C2H2 Zn finger	563..583	CDD:275368	6/19 (32%)
		C2H2 Zn finger	591..611	CDD:275368	8/19 (42%)
		C2H2 Zn finger	619..639	CDD:275368	7/19 (37%)
		C2H2 Zn finger	647..667	CDD:275368	8/19 (42%)
		C2H2 Zn finger	675..695	CDD:275368	7/18 (39%)
		C2H2 Zn finger	703..723	CDD:275368
		C2H2 Zn finger	731..751	CDD:275368
		C2H2 Zn finger	759..779	CDD:275368
		C2H2 Zn finger	787..807	CDD:275368
		C2H2 Zn finger	815..834	CDD:275368
		C2H2 Zn finger	842..862	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336954
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030