DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and Zfp268

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001311345.1	Gene:	Zfp268 / 433801	MGIID:	3651014	Length:	799	Species:	Mus musculus

Alignment Length:	774	Identity:	198/774 - (25%)
Similarity:	298/774 - (38%)	Gaps:	180/774 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 LTMIETVKLEMEPRSVE-KPAYDDPTSD--FEDEDSLDNLPLYNRIQKWKTGRKSVYKCHDCPRS 212
            ||..|  ||:.:.|... |..|....||  |..:       ::..|.:.....:.:|||.:|.:.
Mouse   191 LTQRE--KLQSQQRIYHGKKPYKSSKSDKCFTHQ-------IHLSIHQGIHAEEKIYKCSECDKC 246

  Fly   213 FKRFDFLKRHEMRVHKPETRLYDCSLCIRKFSRSEALEAHLKIHRNSKRSANISEHKKAKAVDLN 277
            |.....|..|: |:|..|.. |.||.|.:.|....:...|.:||...|
Mouse   247 FTHKSHLNIHQ-RIHTGENP-YKCSECDKCFKHKFSFSMHQRIHTGEK----------------- 292

  Fly   278 LCKPHGYKLIECMICQSQYNKIADLRRHLEEHPDIVSLCGRPNMEPHELAELFYPDSKDLSEEQL 342
                 .||..||..|   :|:...||.|...|         ....|::.:|.    .|..:.:..
Mouse   293 -----PYKCSECDKC---FNEKGSLRIHQRIH---------TGENPYKCSEC----DKCFTHKSH 336

  Fly   343 INLIRKDLAAGIYQRFYSITNQSGYEMDLDSSETDSDLDGDHDDQHKRRKKSRKATYSCELCQQK 407
            :|         .:||.:  |.:..|:    .||.|.....:...:..:|..:.:..|.|..|.:.
Mouse   337 LN---------SHQRIH--TGEKPYK----CSECDKCFTKNGSLRIHQRIHTGENPYKCSECDKC 386

  Fly   408 FPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRHHNESQCRNAQKRFLCHKCPLRFRWKH 472
            |.:|..|..||| .|: .:.|:.|..||..|.....|..|  .:....:|.:.|.:|...|..|.
Mouse   387 FTQKSDLNIHQR-IHT-GEKPYKCSECDKCFTHKSHLNSH--QRIHTGEKPYKCSECDKCFTRKF 447

  Fly   473 NLKTHFREHRITNQTFECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHL 537
            :|..|.|.|...| .::||||.:.|.:|..|.:| ..:|..| |...|..|.:.|....:|..|.
Mouse   448 HLSIHQRIHTGEN-PYKCSECDKCFTQKSDLNIH-QRIHTGE-KPYKCSECDKCFTHKSHLNSHQ 509

  Fly   538 KRHGLKEHDIPLAETLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSP 602
            :.|                    .|.|...|..|:..|.|            |..||:||...:
Mouse   510 RIH--------------------TGEKPYKCSECDKCFTR------------KFHLSIHQRIHT- 541

  Fly   603 HNYSITNESGFELQLEDSETEDEMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHE 667
                                        |.:| |.|..|.....|||.:..||| :|..:. |::
Mouse   542 ----------------------------GEKP-YKCSECDKCFTRKFHLSIHQR-IHTGEN-PYK 575

  Fly   668 CDDCIFKCVSKS--IMDHHRQGQCSSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGD 730
            |.:| .||.::.  :..|.|   ..:.||.:.|.:|...|    ..:.|:.:.....:..||
Mouse   576 CSEC-DKCFTRKFHLSIHQR---IHTGEKPYKCSECDKCF----TRKFHLSIHQRIHTGENP--- 629

  Fly   731 RHTQGTGDLEKDATEDGIPLLQCPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGM 795
                                .:|..||:.:..||.||.|.| :| .|:       |.:.||.|..
Mouse   630 --------------------YKCSECDKCFTQKSDLNIHQR-IH-TGE-------KPYKCSECDK 665

  Fly   796 ETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLK 860
            .....:.|.:|.|.||||||:||..|:..|.|...|:.|:|:||||.|:.|:.|.|.|.:...|.
Mouse   666 CFTHKSHLNSHQRIHTGEKPYKCSECDKCFTRKFHLSIHQRIHTGENPYKCSECDKCFTQKSNLN 730

  Fly   861 RHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHR 919
            .|...|:|.||:||:.|:|.:.:...|::|.:.||||.|:.|..|.:.|.:...|..|:
Mouse   731 IHQRIHTGEKPYKCSECDKCFNEKGSLRIHQRIHTGENPYKCSECDKCFTRKFHLSIHQ 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368	6/20 (30%)
		C2H2 Zn finger	236..256	CDD:275368	5/19 (26%)
		C2H2 Zn finger	401..422	CDD:275368	8/20 (40%)
		C2H2 Zn finger	431..447	CDD:275368	5/15 (33%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		C2H2 Zn finger	490..511	CDD:275368	8/20 (40%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	638..659	CDD:275368	8/20 (40%)
		C2H2 Zn finger	668..690	CDD:275368	6/23 (26%)
		C2H2 Zn finger	698..715	CDD:275368	3/16 (19%)
		C2H2 Zn finger	753..774	CDD:275368	9/20 (45%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		zf-H2C2_2	802..825	CDD:290200	12/22 (55%)
		COG5048	814..>886	CDD:227381	29/71 (41%)
		C2H2 Zn finger	818..838	CDD:275368	7/19 (37%)
		zf-H2C2_2	830..855	CDD:290200	12/24 (50%)
		C2H2 Zn finger	846..866	CDD:275368	6/19 (32%)
		zf-H2C2_2	859..883	CDD:290200	10/23 (43%)
		C2H2 Zn finger	874..894	CDD:275368	5/19 (26%)
		C2H2 Zn finger	902..924	CDD:275368	5/18 (28%)
Zfp268	NP_001311345.1	KRAB	12..52	CDD:366587
		C2H2 Zn finger	184..204	CDD:275368	6/14 (43%)
		C2H2 Zn finger	216..232	CDD:275368	3/22 (14%)
		C2H2 Zn finger	240..260	CDD:275368	6/20 (30%)
		C2H2 Zn finger	268..288	CDD:275368	5/19 (26%)
		C2H2 Zn finger	296..316	CDD:275368	7/22 (32%)
		COG5048	320..717	CDD:227381	131/526 (25%)
		C2H2 Zn finger	324..344	CDD:275368	5/32 (16%)
		C2H2 Zn finger	352..372	CDD:275368	4/19 (21%)
		C2H2 Zn finger	380..400	CDD:275368	8/20 (40%)
		C2H2 Zn finger	408..428	CDD:275368	6/21 (29%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	464..484	CDD:275368	8/20 (40%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	9/31 (29%)
		C2H2 Zn finger	548..568	CDD:275368	8/20 (40%)
		C2H2 Zn finger	576..596	CDD:275368	6/23 (26%)
		C2H2 Zn finger	604..624	CDD:275368	4/23 (17%)
		C2H2 Zn finger	632..652	CDD:275368	9/20 (45%)
		C2H2 Zn finger	660..680	CDD:275368	6/19 (32%)
		C2H2 Zn finger	688..708	CDD:275368	7/19 (37%)
		C2H2 Zn finger	716..736	CDD:275368	6/19 (32%)
		C2H2 Zn finger	744..764	CDD:275368	5/19 (26%)
		C2H2 Zn finger	772..792	CDD:275368	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833382
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030