DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and CG11902

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_651389.3	Gene:	CG11902 / 43070	FlyBaseID:	FBgn0028647	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	961	Identity:	354/961 - (36%)
Similarity:	498/961 - (51%)	Gaps:	141/961 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DTDNLLKLATPSKKYPDKLLSEILCELTEINLDATGSQKFPQCLCSGCTKKLMGAYCYVKQAMAA 78
            |.|.....:|.|.:..|...||     ||::.:.|........||...:..||.
  Fly   542 DFDRYYNASTESGQELDLFESE-----TELSDEETSKTSHICLLCGETSNSLMN----------- 590

  Fly    79 NELLMKHLKNGAAPTSTDCLQEAPMELCAEQHVEVKLETEDEDCGENDVTITCSELPEPDETDME 143
               ||||                  ::|.......:|....:.||...|:...  |.:......|
  Fly   591 ---LMKH------------------QICLHSDGVAELPCRCDYCGSGFVSKAL--LQQHRRHRCE 632

  Fly   144 SKKS-----VDPLTMIETVKLEMEPRSVEKPAYDDPTSDFEDEDSLDNLPLYNRIQKWKTGRKSV 203
            .|.|     :..:..|.....|...::     :.:.|.|.|:                   |.:.
  Fly   633 KKHSRFHCRICNIRFIWESNYEKHEKT-----HHNKTKDAEE-------------------RPTK 673

  Fly   204 YKCHDCPRSFKRFDFLKRHEMRVHKPETRL-YDCSLCIRKFSRSEALEAHLKIHRNSKRSANISE 267
            .||..|.:.|.....|.||: |:|:|::.. :||..|.|:|.|.:.|::|||:|..:....|
  Fly   674 LKCDQCEKVFIWHKDLNRHK-RLHQPQSAAQFDCPHCHRRFHRKDGLKSHLKVHAGNSDYIN--- 734

  Fly   268 HKKAKAVDLN-------LCKPHGYKLIECMICQSQYNKIADLRRHLEEHPDIVSLCGRPNMEPHE 325
             .:....|:|       |.:|||.|||:||||.|:::||:|||.||..|...:|..     |..:
  Fly   735 -NQPVVPDVNQEMILARLSRPHGCKLIQCMICLSRHSKISDLRSHLSSHQYELSFA-----EDRD 793

  Fly   326 L---AELFYPDSKD-LSEEQLINLIRKDLAAGI-YQRFYSITNQSGYEMDLDSSETDSDLDGDHD 385
            :   ::.||||.:: |.:::|..:|..|:.... ..||.||||::|.|::|:|||||:  :.:.:
  Fly   794 IPSASKAFYPDLENTLEKDELAEMIMADVQREFDLDRFISITNEAGLELNLESSETDT--ESEQE 856

  Fly   386 DQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRHHNES 450
            |.|.      ...|.|.||.....||:|||.||.:.|.|.:|..||..|..|||:..||.||:.:
  Fly   857 DNHS------SLNYPCNLCTTVVKRKHQLYAHQLEEHKWEEAVLVCSNCQTRFVNESLLDHHSRT 915

  Fly   451 QCRNAQKRFLCHKCPLRFRWKHNLKTHFREHRITNQ------------TFECSECKRVFDKKKSL 503
            .|.|.||.|.|.||||||||:.|||.|.....:.::            ..:|.:|.|.|..:|.|
  Fly   916 LCHNPQKLFQCRKCPLRFRWRENLKLHMEVFHMLDELSIQDDLPKVDGDLQCGKCNRSFRMQKDL 980

  Fly   504 TVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAATSRPNGAKRITC 568
            |.|.| :|.:||.:..|:||:|:|||...|::|:.|||:....:|.||.::.:...|.|.|::.|
  Fly   981 TRHTL-MHGQESNIFRCRWCARRFYRRANLLQHIARHGISVSQLPYAEAILDSYVNPGGRKKVEC 1044

  Fly   569 RMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSETEDE------MQ 627
            |:||:.|..|..||.|::   .:....|..|.|..||||||:.|||:.|.||||:||      ..
  Fly  1045 RVCNVSFPTIAALRLHLE---TMPAGSHHDYSSLQNYSITNQMGFEMDLYDSETDDEDSRTHIKP 1106

  Fly   628 PGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCVSKSIMDHHRQGQCSST 692
            ||..|.  |.|.:|.::|.||||:.|||:.|||.:|:...||.|:||.|...|:.||::.||.:.
  Fly  1107 PGAPSS--YTCNMCQLRCLRKFELYQHQQAMHRMEKISDGCDSCLFKSVCPEIISHHKRTQCENR 1169

  Fly   693 EKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPHCD 757
            ||:..|.:|.|||||..||..|:.|||.|:  .:...|...:.:||..|  ||..:  .||..|.
  Fly  1170 EKQFKCTRCGYKFMWESNLLLHMDLQHVKT--EDQELDESKEASGDEPK--TEGQV--FQCGLCT 1228

  Fly   758 RTYQMKSRLNNHIRDVHINGDRKRKEA-----------IKRFLCSLCGMETRSAAALVTHMRRHT 811
            |.|..|.||..|::..| ..|.|...|           .|||||:.||....|::.|:.||||||
  Fly  1229 RKYNRKDRLTAHLKKFH-GPDCKPSTAKTPNRPISPKEPKRFLCAFCGKAVSSSSNLIIHMRRHT 1292

  Fly   812 GEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTY 876
            |||||||:.|.|||||.|:|..|||.||||:|..||||.|.||||.||::||..|||.:|:||||
  Fly  1293 GEKPFKCEYCTMAFPRSSDLQCHRRTHTGERPHVCTVCQKGFARSYKLQQHMRIHSGERPYKCTY 1357

  Fly   877 CEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHRLMRRHFDE 927
            ||||:.|:.||.||:::||||.|:.||.|||||||.:.|:.||:.:.|::|
  Fly  1358 CEKSFTQSNDLTLHIRRHTGERPYQCGVCGERFIQGTALKNHRMQQSHYEE 1408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	15/69 (22%)
		C2H2 Zn finger	206..227	CDD:275368	7/20 (35%)
		C2H2 Zn finger	236..256	CDD:275368	9/19 (47%)
		C2H2 Zn finger	401..422	CDD:275368	10/20 (50%)
		C2H2 Zn finger	431..447	CDD:275368	7/15 (47%)
		C2H2 Zn finger	461..481	CDD:275368	13/19 (68%)
		C2H2 Zn finger	490..511	CDD:275368	9/20 (45%)
		C2H2 Zn finger	520..540	CDD:275368	9/19 (47%)
		C2H2 Zn finger	638..659	CDD:275368	10/20 (50%)
		C2H2 Zn finger	668..690	CDD:275368	10/21 (48%)
		C2H2 Zn finger	698..715	CDD:275368	9/16 (56%)
		C2H2 Zn finger	753..774	CDD:275368	8/20 (40%)
		C2H2 Zn finger	790..810	CDD:275368	8/19 (42%)
		zf-H2C2_2	802..825	CDD:290200	16/22 (73%)
		COG5048	814..>886	CDD:227381	47/71 (66%)
		C2H2 Zn finger	818..838	CDD:275368	12/19 (63%)
		zf-H2C2_2	830..855	CDD:290200	15/24 (63%)
		C2H2 Zn finger	846..866	CDD:275368	13/19 (68%)
		zf-H2C2_2	859..883	CDD:290200	15/23 (65%)
		C2H2 Zn finger	874..894	CDD:275368	12/19 (63%)
		C2H2 Zn finger	902..924	CDD:275368	12/21 (57%)
CG11902	NP_651389.3	zf-AD	6..83	CDD:285071
		C2H2 Zn finger	208..228	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	384..405	CDD:275368
		C2H2 Zn finger	417..437	CDD:275368
		C2H2 Zn finger	447..463	CDD:275368
		C2H2 Zn finger	578..599	CDD:275368	9/52 (17%)
		C2H2 Zn finger	610..629	CDD:275368	4/20 (20%)
		C2H2 Zn finger	640..660	CDD:275368	2/24 (8%)
		C2H2 Zn finger	676..696	CDD:275368	7/20 (35%)
		C2H2 Zn finger	706..726	CDD:275368	9/19 (47%)
		C2H2 Zn finger	762..782	CDD:275368	12/19 (63%)
		C2H2 Zn finger	866..887	CDD:275368	10/20 (50%)
		C2H2 Zn finger	896..918	CDD:275368	9/21 (43%)
		C2H2 Zn finger	926..947	CDD:275368	13/20 (65%)
		C2H2 Zn finger	967..987	CDD:275368	9/20 (45%)
		C2H2 Zn finger	996..1016	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1044..1063	CDD:275368	9/21 (43%)
		C2H2 Zn finger	1224..1244	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1271..1291	CDD:275368	8/19 (42%)
		zf-H2C2_2	1283..1306	CDD:290200	16/22 (73%)
		COG5048	1295..>1367	CDD:227381	47/71 (66%)
		C2H2 Zn finger	1299..1319	CDD:275368	12/19 (63%)
		zf-H2C2_2	1311..1336	CDD:290200	15/24 (63%)
		C2H2 Zn finger	1327..1347	CDD:275368	13/19 (68%)
		zf-H2C2_2	1340..1364	CDD:290200	15/23 (65%)
		C2H2 Zn finger	1355..1375	CDD:275368	12/19 (63%)
		zf-H2C2_2	1367..1392	CDD:290200	16/24 (67%)
		C2H2 Zn finger	1383..1401	CDD:275368	11/17 (65%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42822at6656
OrthoFinder	1	1.000	-	-		FOG0014266
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.920