DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18476 and CG11247

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	121/561 - (21%)
Similarity:	182/561 - (32%)	Gaps:	231/561 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 LDSSETD-SDLDGDHDD--QHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVCG 432
            :|..|.| .:.|...||  |.:.:|.:||.        :...||:                |||.
  Fly    56 VDEEEDDGGEQDSKDDDYVQPQLKKSARKG--------EPVKRKH----------------HVCS 96

  Fly   433 RCDGRF-VSLQLLRH---HNESQCRNAQKRFLCHKCPLRFRWKHNLKTHF---REHRITNQTFEC 490
            :|...| ....|.||   |::      ::...|..|...:|...|||.|.   .|||   :.|.|
  Fly    97 QCSKEFGGKTDLQRHMLIHSD------ERPHKCKDCGKSYRQAVNLKNHITTAHEHR---KQFVC 152

  Fly   491 SECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIA 555
            |:|.:.|..|:.|.:| :.:|:.| |..||..|.:||.|...|.:|:..|
  Fly   153 SQCPKSFALKERLRLH-MRLHSGE-KPYPCDLCDKKFARGGQLQQHMVSH--------------- 200

  Fly   556 ATSRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDS 620

  Fly   201 ----------------------------------------------------------------- 200

  Fly   621 ETEDEMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCVSKSIMDHHR 685
                                             |:.::.:|:
  Fly   201 ---------------------------------HKTSIQQFN----------------------- 209

  Fly   686 QGQCSSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPL 750
                        |.|||..|....||..|:              :||.||   :|.
  Fly   210 ------------CTKCSASFSTNANLRVHM--------------ERHEQG---MEH--------- 236

  Fly   751 LQCPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKP 815
             :|..|:..:..:..|..||...|        ..:.:|.|.:|.........|.|||:|||..|.
  Fly   237 -RCSICENQFANELALRAHINQEH--------HKLTQFECEICHKMIEPDEDLATHMQRHTAVKT 292

  Fly   816 FKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEK- 879
            ..|::|...|.:.|:...|.||||||:|:.|.:|.:.||.|..||.|:..|:|.||.:|..||.
  Fly   293 HVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDE 357

  Fly   880 -SYRQAKDLKLHLQQ-HTGECPFVCGTCGERFIQSSTLEKH 918
             ::.|...||.|::: |..:.|::|..|.:.|.....|:.|
  Fly   358 VAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	401..422	CDD:275368	2/20 (10%)
		C2H2 Zn finger	431..447	CDD:275368	6/19 (32%)
		C2H2 Zn finger	461..481	CDD:275368	7/22 (32%)
		C2H2 Zn finger	490..511	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	638..659	CDD:275368	1/20 (5%)
		C2H2 Zn finger	668..690	CDD:275368	0/21 (0%)
		C2H2 Zn finger	698..715	CDD:275368	7/16 (44%)
		C2H2 Zn finger	753..774	CDD:275368	5/20 (25%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		zf-H2C2_2	802..825	CDD:290200	10/22 (45%)
		COG5048	814..>886	CDD:227381	29/73 (40%)
		C2H2 Zn finger	818..838	CDD:275368	6/19 (32%)
		zf-H2C2_2	830..855	CDD:290200	11/24 (46%)
		C2H2 Zn finger	846..866	CDD:275368	8/19 (42%)
		zf-H2C2_2	859..883	CDD:290200	10/25 (40%)
		C2H2 Zn finger	874..894	CDD:275368	7/22 (32%)
		C2H2 Zn finger	902..924	CDD:275368	5/17 (29%)
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	58/360 (16%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	6/30 (20%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	7/20 (35%)
		zf-H2C2_2	165..189	CDD:290200	10/25 (40%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	65/359 (18%)
		C2H2 Zn finger	210..230	CDD:275370	8/33 (24%)
		C2H2 Zn finger	238..260	CDD:275371	6/29 (21%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	121	1.000	Inparanoid score	I1302
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42822at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.060