DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG18476 and D19A

DIOPT Version :9

Sequence 1:NP_731615.1 Gene:CG18476 / 41404 FlyBaseID:FBgn0037931 Length:936 Species:Drosophila melanogaster
Sequence 2:NP_477304.1 Gene:D19A / 38718 FlyBaseID:FBgn0022935 Length:845 Species:Drosophila melanogaster


Alignment Length:955 Identity:198/955 - (20%)
Similarity:315/955 - (32%) Gaps:305/955 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ICRTC-DSTDTDNLLKLATPSKKYPDKLLSEILCELTEINLDATGSQKFPQCLCSGCTKKLMGAY 69
            :||.| :....|....|      |....||:.||..|.::::.  :..||:.||:.|..||...:
  Fly    12 LCRICLNHLQNDAAYDL------YLVPGLSKKLCFCTSLSVEQ--NDGFPKNLCTLCYTKLNELH 68

  Fly    70 CYVKQAMAANELLMKHLKNG--AAPTSTD------CLQEAPMELCAEQHVEV------KLETEDE 120
            .:.||.:.:.:.....:.:.  |..:|.|      .:|:.|.|  .|.||..      |:|..: 
  Fly    69 DFQKQCVDSVQKFQDLVASNVFACQSSFDVFDPNVAVQDYPAE--EEDHVNYDPLLNHKMELIE- 130

  Fly   121 DCGENDVTITCSEL-PEPDETDMESKKSVDPLTMIETVKLEMEPRSVEKPAYDDPTSDFEDEDSL 184
              .|.||......: .|.:|.:.|:|...|....: :||:..:..|:|....:|...|||...|.
  Fly   131 --NEEDVFKMLEHVDKEAEEVEKEAKVEEDDGGNV-SVKMFDDDSSIESGNDNDHDLDFEPNSSD 192

  Fly   185 DNLPLYNRIQKWKTGRKSVYKCHDCPRSFKRFDFLKRHEMRVH------KP----ETRLYDCSLC 239
            |::||..|::...||        ..|:. .||..|.:.:.|..      ||    |..|.|.|  
  Fly   193 DDIPLAQRMRGPATG--------SGPQQ-DRFSNLDKPKPRPRGRPKKIKPPPPEEEELSDSS-- 246

  Fly   240 IRKFSRSEALEAHLKIHRNSKRSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIADLRR 304
                |.|:          :|:...:..:..|.|.:.:.  :.|.:::|:|.||..::.|......
  Fly   247 ----SESD----------DSEDGTSRGDKPKRKRIPIE--ERHLHRIIDCHICHQKFKKAIRYEE 295

  Fly   305 HLEEHPDI------VSLCGRPNMEPHELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITN 363
            |::.|.|:      |..|.:                                         ..|.
  Fly   296 HMKYHNDLLPFQCKVETCKK-----------------------------------------GFTT 319

  Fly   364 QSGYEMDLDSSETDSDLDGDHDDQHKRRKKSRKATYSC--ELCQQKFPRKYQLYDHQRQ------ 420
            .:|..:.:|.:.|:                 ....::|  |.|.:.|||...|..|.::      
  Fly   320 ANGLRIHIDHAHTE-----------------LSEVHACIAEGCGKTFPRVRLLTFHMKKVHGITK 367

  Fly   421 ----------------------------SHSWSDAPHVCGRCDGRFVSLQLLRHH--NESQCRNA 455
                                        .|:..:.|:.|..|..|||....||.|  ..:..:| 
  Fly   368 AAAPLRDFPCTECDTVFRCPTALKKHMYKHTGEELPYPCNICGKRFVINSALRDHLMRHAGIKN- 431

  Fly   456 QKRFLCHKCP-------LRFRWKHNLKTHFREHRITNQTFECSECKRVFDKKKSLTVHLLSVHAE 513
                  |.||       .|..|..::.||.:|.:     |:|.:|......|::|:.|:..|| |
  Fly   432 ------HVCPYCGVGKTTRQEWNAHILTHTKEKK-----FKCRQCDHASHNKQALSNHVKVVH-E 484

  Fly   514 ESKLIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAATSRPNGAKRITCRMCNLHFERI 578
            :.|...||:|.:.|.         |.|..|.|:           ....|.|...|::|...|...
  Fly   485 KRKDFACQYCGKTFG---------KSHACKVHE-----------RSHTGEKCCECKICGKIFLCE 529

  Fly   579 VDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSETEDEMQPGVGSRPVYICELCSV 643
            ..|..|        |..|:..|.|....:..:....:..:.|      .|..|..|:      .:
  Fly   530 KSLTKH--------LKTHEKRDLPPAEPLRQQLNIPMPGQMS------VPMPGQMPM------QM 574

  Fly   644 QCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYKFMWP 708
            |......|..:|        ||.|  |.:..|          .|..::...|            |
  Fly   575 QTDGLVPMDPNQ--------MPSE--DMLKAC----------GGGTAAVPPK------------P 607

  Fly   709 ENLE--QHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPHCDRTYQMKSRLNNHIR 771
            :|..  |.:.:.....:..||                    ||.:..|..........:...|| 
  Fly   608 KNSRRVQRVDISQLAGTAVNP--------------------IPSVSVPSWSPQVNFTKKEGQHI- 651

  Fly   772 DVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMR-RHTGEKPFKCDLCEMAFPRHSELASHR 835
                              |..||....:...:..|.: .|...|.|.|..|...|.:...|..|.
  Fly   652 ------------------CPGCGRGFNNIGNMKLHYKIIHEKVKDFACRFCPKRFSKAQILRHHE 698

  Fly   836 RMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKS 880
            .:|||||||.|.:|||.|.:...||:|:.||.  ||::....|:|
  Fly   699 WIHTGEKPFECKICGKHFRQETALKKHIKTHE--KPNRRHVPERS 741

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18476NP_731615.1 zf-AD 6..84 CDD:285071 20/78 (26%)
C2H2 Zn finger 206..227 CDD:275368 5/20 (25%)
C2H2 Zn finger 236..256 CDD:275368 3/19 (16%)
C2H2 Zn finger 401..422 CDD:275368 8/56 (14%)
C2H2 Zn finger 431..447 CDD:275368 7/15 (47%)
C2H2 Zn finger 461..481 CDD:275368 7/26 (27%)
C2H2 Zn finger 490..511 CDD:275368 5/20 (25%)
C2H2 Zn finger 520..540 CDD:275368 5/19 (26%)
C2H2 Zn finger 638..659 CDD:275368 3/20 (15%)
C2H2 Zn finger 668..690 CDD:275368 3/21 (14%)
C2H2 Zn finger 698..715 CDD:275368 3/18 (17%)
C2H2 Zn finger 753..774 CDD:275368 3/20 (15%)
C2H2 Zn finger 790..810 CDD:275368 4/20 (20%)
zf-H2C2_2 802..825 CDD:290200 6/23 (26%)
COG5048 814..>886 CDD:227381 28/67 (42%)
C2H2 Zn finger 818..838 CDD:275368 5/19 (26%)
zf-H2C2_2 830..855 CDD:290200 14/24 (58%)
C2H2 Zn finger 846..866 CDD:275368 8/19 (42%)
zf-H2C2_2 859..883 CDD:290200 9/22 (41%)
C2H2 Zn finger 874..894 CDD:275368 2/7 (29%)
C2H2 Zn finger 902..924 CDD:275368
D19ANP_477304.1 zf-AD 12..83 CDD:214871 20/78 (26%)
C2H2 Zn finger 343..362 CDD:275368 7/18 (39%)
C2H2 Zn finger 377..397 CDD:275368 0/19 (0%)
zf-H2C2_2 389..414 CDD:290200 5/24 (21%)
C2H2 Zn finger 406..426 CDD:275368 8/19 (42%)
C2H2 Zn finger 434..454 CDD:275368 4/19 (21%)
C2H2 Zn finger 462..483 CDD:275368 5/20 (25%)
C2H2 Zn finger 491..511 CDD:275368 8/39 (21%)
C2H2 Zn finger 519..539 CDD:275368 6/27 (22%)
C2H2 Zn finger 652..673 CDD:275368 4/20 (20%)
C2H2 Zn finger 681..701 CDD:275368 5/19 (26%)
zf-H2C2_2 694..718 CDD:290200 14/23 (61%)
C2H2 Zn finger 709..729 CDD:275368 8/19 (42%)
tolA_full 724..>814 CDD:274303 7/20 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 121 1.000 Inparanoid score I1302
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
11.050

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