DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and Zfp26

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001102465.2	Gene:	Zfp26 / 367033	RGDID:	1565847	Length:	956	Species:	Rattus norvegicus

Alignment Length:	973	Identity:	247/973 - (25%)
Similarity:	373/973 - (38%)	Gaps:	251/973 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LLSEILCELTEINLDATGSQKFPQCLCSGCTKKLMGAYCYVKQAMAANELLMK---HLKNGAAPT 93
            |..|::.|..: ||...|.|.|...|.|...:|       |:..:....:|.:   |||     |
  Rat   128 LYREVMLENYQ-NLATVGGQLFKPSLISWLERK-------VELTVMEQGILQEWEMHLK-----T 179

  Fly    94 STDCLQE--------APMELCAE-------QHVEVKLETEDEDCGENDVTITCSE---------- 133
            ....||:        ..|:|..|       ..::|.....::.|.:..::...:|
  Rat   180 KRTALQQDRFWSDMSNGMQLGRELSGGELGDSIQVGTVFSEDSCPQTYISTPSTEDTSACHLRGK 244

  Fly   134 --LPEPDETDMES-----KKSVDPLTMIETVKLEMEPRSVEKPAYDDPTSDFEDEDSLDNLPLYN 191
              ||...||..|.     .:.|.|||:...|.
  Rat   245 DFLPPLKETSTEENILQLNQCVKPLTLTPDVS--------------------------------- 276

  Fly   192 RIQKWKTGRKSVYKCHDCPRSFKRFDFLKRH-----EMRVHKP--------------------ET 231
              |:..|..||| :|.||.::|.....|:.|     |..:|||                    |.
  Rat   277 --QRMCTLEKSV-ECSDCGKTFVNELELQAHSSSHSENNLHKPEECGQAFTHPVSHDGHVIPTEK 338

  Fly   232 RLYDCSLCIRKFSRSEALEAHLKIHRNSKRSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQY 296
            :.|:|..|.:.|:.    ..:|.||        :..|...|..|   ||..|....|      :.
  Rat   339 KYYECKKCEKFFTH----PVYLNIH--------VQSHTVEKPYD---CKECGKAFTE------RS 382

  Fly   297 NKIADLRRHLEEHPDIVSLCGRPNMEPHELAELF--YPDSKDLSEEQLINLIRKDLAAGIYQRFY 359
            :.|..||:|..|.......||:..::|..|.|..  :...|....:|..|..........:.|.:
  Rat   383 SLIVHLRQHTREKSYECKECGKTFIQPSRLTEHMRSHTGEKPYQCDQCGNAFASSSYLTTHLRTH 447

  Fly   360 SITNQSGYEMDL-DSSETDSDLDGDHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHS 423
              |.:..:|.:: ..:.|.|.....|...|...|     .|.|::|.:.|..:..|..|.|: |:
  Rat   448 --TGEKPFECNICGKAFTRSSYLLGHIRTHTGEK-----PYECKVCGKAFSGRSWLTIHLRK-HT 504

  Fly   424 WSDAPHVCGRCDGRFVSLQLLRHHNESQCRNAQKRFLCHKCPLRFRWKHNLKTHFREHRITN-QT 487
             .:.|:.|..|:..|.|...|..|.::  ...:|.|.|..|...||....||||||.|  |. :.
  Rat   505 -GERPYPCTECEKAFTSFAQLTEHIKT--HTGEKPFRCKVCARTFRNSSCLKTHFRIH--TGIKP 564

  Fly   488 FECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRH-GLKEHD----- 546
            ::|:.|.:.|..:..||.|:| :|..| |...|:.|.:.|.....||:|::.| |.|..:
  Rat   565 YKCNYCGKDFTARSGLTKHVL-IHNGE-KPYECKECGKAFSTSSGLVEHIRIHTGEKPFECYQCG 627

  Fly   547 --IPLAETLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITN 609
              :..:.:|:.......|.|...|..|:..|.|...||.|
  Rat   628 KALAHSSSLVGHLRTHTGEKPFECNQCDKTFTRSSYLRIH------------------------- 667

  Fly   610 ESGFELQLEDSETEDEMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDC--- 671
                            |:...|.:| |.|:.|......:..:.:|.|| |..:: |:||.:|
  Rat   668 ----------------MRTHTGEKP-YECKECGKTFPERSCLTKHIRT-HTGER-PYECKECGKG 713

  Fly   672 --IFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQ 734
              .|..::..|..|       |:|:...|..|:..|....:||.|..:              ||
  Rat   714 FISFAQLTVHIKTH-------SSERPFQCKVCTKSFRNSSSLETHFRI--------------HT- 756

  Fly   735 GTGDLEKDATEDGIPLLQCPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRS 799
                        |:...:|.:|.:.:..:|.|..|:|: | .|:       |.:.|..||....:
  Rat   757 ------------GVKPYKCSYCGKDFTARSGLTIHLRN-H-TGE-------KSYACQECGKAFST 800

  Fly   800 AAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHML 864
            ::.|:.|:|.|.|||||:||.|..||...|.|..|.::|||||||.||||||.|..|..|..||.
  Rat   801 SSGLIAHIRSHKGEKPFECDHCGKAFASSSYLNVHLKIHTGEKPFQCTVCGKTFTCSSYLPVHMR 865

  Fly   865 THSGLKPHKCTYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHRLMRRHFDE 927
            ||:|.||.:|..|.||:..:..|::|::.||||.|:||..||:.|.:.|.|.||  :|:|..|
  Rat   866 THTGEKPFQCIICGKSFLWSSYLRVHMRIHTGEKPYVCQYCGKAFTEHSGLNKH--LRKHTGE 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	13/51 (25%)
		C2H2 Zn finger	206..227	CDD:275368	7/25 (28%)
		C2H2 Zn finger	236..256	CDD:275368	4/19 (21%)
		C2H2 Zn finger	401..422	CDD:275368	6/20 (30%)
		C2H2 Zn finger	431..447	CDD:275368	5/15 (33%)
		C2H2 Zn finger	461..481	CDD:275368	10/19 (53%)
		C2H2 Zn finger	490..511	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	668..690	CDD:275368	5/26 (19%)
		C2H2 Zn finger	698..715	CDD:275368	5/16 (31%)
		C2H2 Zn finger	753..774	CDD:275368	6/20 (30%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		zf-H2C2_2	802..825	CDD:290200	12/22 (55%)
		COG5048	814..>886	CDD:227381	38/71 (54%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	16/24 (67%)
		C2H2 Zn finger	846..866	CDD:275368	11/19 (58%)
		zf-H2C2_2	859..883	CDD:290200	12/23 (52%)
		C2H2 Zn finger	874..894	CDD:275368	6/19 (32%)
		C2H2 Zn finger	902..924	CDD:275368	9/21 (43%)
Zfp26	NP_001102465.2	KRAB	104..162	CDD:214630	12/41 (29%)
		C2H2 Zn finger	288..308	CDD:275368	6/19 (32%)
		COG5048	338..751	CDD:227381	117/499 (23%)
		C2H2 Zn finger	343..363	CDD:275368	6/31 (19%)
		C2H2 Zn finger	371..391	CDD:275368	7/25 (28%)
		C2H2 Zn finger	399..419	CDD:275368	5/19 (26%)
		C2H2 Zn finger	427..447	CDD:275368	3/19 (16%)
		C2H2 Zn finger	455..475	CDD:275368	3/19 (16%)
		C2H2 Zn finger	483..503	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..531	CDD:275368	6/21 (29%)
		C2H2 Zn finger	539..559	CDD:275368	10/19 (53%)
		C2H2 Zn finger	567..587	CDD:275368	7/20 (35%)
		COG5048	591..>918	CDD:227381	118/413 (29%)
		C2H2 Zn finger	595..615	CDD:275368	6/19 (32%)
		C2H2 Zn finger	623..643	CDD:275368	1/19 (5%)
		C2H2 Zn finger	651..671	CDD:275368	8/60 (13%)
		C2H2 Zn finger	679..699	CDD:275368	5/20 (25%)
		C2H2 Zn finger	707..727	CDD:275368	4/19 (21%)
		C2H2 Zn finger	735..755	CDD:275368	6/33 (18%)
		C2H2 Zn finger	763..783	CDD:275368	6/20 (30%)
		C2H2 Zn finger	791..811	CDD:275368	6/19 (32%)
		C2H2 Zn finger	819..839	CDD:275368	8/19 (42%)
		C2H2 Zn finger	847..867	CDD:275368	11/19 (58%)
		C2H2 Zn finger	875..895	CDD:275368	6/19 (32%)
		C2H2 Zn finger	903..923	CDD:275368	9/21 (43%)
		C2H2 Zn finger	931..947	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45252
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020