DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and Prdm9

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001102373.2	Gene:	Prdm9 / 365155	RGDID:	1305247	Length:	796	Species:	Rattus norvegicus

Alignment Length:	884	Identity:	194/884 - (21%)
Similarity:	326/884 - (36%)	Gaps:	197/884 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 MESKKSVDPLTMIETVKLEMEPRSVEKPAYDDPTSDFEDEDSLDNLPLYNRIQKW-KTGRKSVYK 205
            |.:.|..:..|..:..|||.:|:.               :|...::.:|...::| :.|.....:
  Rat     5 MNTNKPEENSTEGDAGKLEWKPKV---------------KDEFKDISIYFSKEEWAEMGEWEKIR 54

  Fly   206 CHDCPRSFKRFDFLKRHEMRVHKPETRLYDCSLCIRKFSRSEALE------------------AH 252
            ..:..|::|   .|....:|..:|....|.......:.:.:|..:                  .|
  Rat    55 YRNVKRNYK---MLISIGLRAPRPAFMCYQRQAIKPQINDNEDSDEEWTPKQQVSSPWVPFRVKH 116

  Fly   253 LKIHRNSKRSANISEHKKAKAV--DLNLCKPHGYKLIECMICQSQ--------YNKIADLRR--- 304
            .|..:.:.|.. :|:....|.|  ..||....|.:..:..:|..:        :.|...|||
  Rat   117 SKQQKETPRMP-LSDKSSVKEVFGIENLLNTSGSEHAQKPVCSPEEGNTSGQHFGKKLKLRRKNV 180

  Fly   305 -----HLEEHPDI-----------------------VSLC---GRPNMEPHELAELFYPDSKDLS 338
                 .|.|..|:                       :..|   |.|......:.:..:|:...||
  Rat   181 EVNRYRLRERKDLAYEEVSEPQDDDYLYCEKCQNFFIDSCPNHGPPVFVKDSVVDRGHPNHSVLS 245

  Fly   339 EEQLINLIRKDLAAGIYQRFYSITNQSGYEMDLDSSETDSDLD-----GDHDDQHKRRKKSRKAT 398
            ....:.:    ..:||.:....:.|::            |||.     |.:..|....:::..:.
  Rat   246 LPPGLRI----GPSGIPEAGLGVWNEA------------SDLPVGLHFGPYKGQITEDEEAANSG 294

  Fly   399 YSCELCQQKFPRKYQLYDHQRQSH-SWSDAPHVCGRCDGRFVSLQLLRHHNE---SQCR--NAQK 457
            ||..:.:.:  ..|:..|.|.:|. :|....: |.| |....:|...::|.:   ..||  ...:
  Rat   295 YSWLITKGR--NCYEYVDGQDESQANWMRYVN-CAR-DDEEQNLVAFQYHRKIFYRTCRVIRPGR 355

  Fly   458 RFLC-----HKCPLRFRWKHNLKTHFREHR-ITNQTFECSECKRVFDKKKSLTVHLLSVHAEE-- 514
            ..|.     :...|..:|...:|..|...| :..:...|..|...|..:|.||.|:...|..|
  Rat   356 ELLVWYGDEYGQELGIKWGSKMKKGFTAGRELRTEIHPCFLCSLAFSSQKFLTQHVEWNHRTEIF 420

  Fly   515 ---SKLI------PCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAATSRPN---GAKRIT 567
               |..|      ||.         |.|.:|.......:.    |...:...|:|.   ..:||:
  Rat   421 PGASARINPKPGDPCP---------DQLQEHFDSQNKNDK----ASNEVKRKSKPRHKWTRQRIS 472

  Fly   568 CRMCNLHFE--RIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQL-----EDSETEDE 625
            ....:...|  |..:.:..::.||:...:.:.. |:..::..:..|..|.|.     :.|...:.
  Rat   473 TAFSSTLKEQMRSEESKRTVEEELRTGQTTNIE-DTAKSFIASETSRIERQCGQCFSDKSNVSEH 536

  Fly   626 MQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCVSKSIMDHHRQGQCS 690
            .:...|.:| |||..|.....:|.::|:|||| |..:| |:.|.:|......||.:..|:  :..
  Rat   537 QRTHTGEKP-YICRECGRGFSQKSDLIKHQRT-HTEEK-PYICRECGRGFTQKSDLIKHQ--RTH 596

  Fly   691 STEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPH 755
            :.||.:.|.:|...|     .::..|::|.::.    ||::                 |.: |..
  Rat   597 TEEKPYICRECGRGF-----TQKSDLIKHQRTH----TGEK-----------------PYI-CRE 634

  Fly   756 CDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDL 820
            |.|.:..||.|..|        .|...|. |.::|..||......::|:.|.|.||||||:.|..
  Rat   635 CGRGFTQKSDLIKH--------QRTHTEE-KPYICRECGRGFTQKSSLIRHQRTHTGEKPYICRE 690

  Fly   821 CEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAK 885
            |.:.|.:.|.|..|.|.||||||:.|..||..|.|...|.:|..||:|.||:.|..|.:......
  Rat   691 CGLGFTQKSNLIRHLRTHTGEKPYICRECGLGFTRKSNLIQHQRTHTGEKPYICRECGQGLTWKS 755

  Fly   886 DLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHRLMRRH 924
            .|..|.:.||||.|::|..||..|...|:|.:|:  |.|
  Rat   756 SLIQHQRTHTGEKPYICRECGRGFTWKSSLIQHQ--RTH 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368	4/20 (20%)
		C2H2 Zn finger	236..256	CDD:275368	3/37 (8%)
		C2H2 Zn finger	401..422	CDD:275368	3/20 (15%)
		C2H2 Zn finger	431..447	CDD:275368	4/15 (27%)
		C2H2 Zn finger	461..481	CDD:275368	4/24 (17%)
		C2H2 Zn finger	490..511	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	4/19 (21%)
		C2H2 Zn finger	638..659	CDD:275368	8/20 (40%)
		C2H2 Zn finger	668..690	CDD:275368	5/21 (24%)
		C2H2 Zn finger	698..715	CDD:275368	3/16 (19%)
		C2H2 Zn finger	753..774	CDD:275368	7/20 (35%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		zf-H2C2_2	802..825	CDD:290200	11/22 (50%)
		COG5048	814..>886	CDD:227381	29/71 (41%)
		C2H2 Zn finger	818..838	CDD:275368	7/19 (37%)
		zf-H2C2_2	830..855	CDD:290200	13/24 (54%)
		C2H2 Zn finger	846..866	CDD:275368	7/19 (37%)
		zf-H2C2_2	859..883	CDD:290200	9/23 (39%)
		C2H2 Zn finger	874..894	CDD:275368	4/19 (21%)
		C2H2 Zn finger	902..924	CDD:275368	8/21 (38%)
Prdm9	NP_001102373.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		4/17 (24%)
		KRAB_A-box	32..89	CDD:383038	9/59 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..172		1/22 (5%)
		SSXRD	175..205	CDD:370541	6/29 (21%)
		PR-SET_PRDM7_9	244..372	CDD:380970	26/147 (18%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:Q96EQ9	260..262		0/1 (0%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q96EQ9	292..298		2/5 (40%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:Q96EQ9	324..325		0/1 (0%)
		COG5048	402..748	CDD:227381	105/400 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..497		8/57 (14%)
		C2H2 Zn finger	521..540	CDD:275368	2/18 (11%)
		C2H2 Zn finger	548..568	CDD:275368	8/20 (40%)
		C2H2 Zn finger	576..596	CDD:275368	5/21 (24%)
		C2H2 Zn finger	604..624	CDD:275368	5/24 (21%)
		C2H2 Zn finger	632..652	CDD:275368	8/27 (30%)
		C2H2 Zn finger	660..680	CDD:275368	6/19 (32%)
		C2H2 Zn finger	688..708	CDD:275368	7/19 (37%)
		C2H2 Zn finger	716..736	CDD:275368	7/19 (37%)
		C2H2 Zn finger	744..764	CDD:275368	4/19 (21%)
		C2H2 Zn finger	772..792	CDD:275368	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000