DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and Zfp52

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001014180.1	Gene:	Zfp52 / 361487	RGDID:	1359149	Length:	755	Species:	Rattus norvegicus

Alignment Length:	899	Identity:	204/899 - (22%)
Similarity:	319/899 - (35%)	Gaps:	281/899 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 CLCSGCTKKLMGAYCYVKQAMAANEL--LMKHLKNGAAPTSTDCLQEAPMELCA----------- 107
            |:|....:.:...    |::...|||  :::...|.|....:|.::.:....|.
  Rat    88 CICETVHQHVKTE----KESCQCNELGEMLRGPSNCALYKRSDTIETSNNCRCCKDRGASVDSSN 148

  Fly   108 -EQHVEVKLETEDEDCGENDVTIT---CSELPEPD----------ETDMESKKSVDPLTMIETVK 158
             :||...  .|.:|.|...:...:   ||.:.|..          :.:.:.:.|.....|.:||.
  Rat   149 PDQHTST--HTGEEPCTSKNCEKSFSLCSNIREDQRLYTAKKEHKQDEYDDRFSSTYSLMQQTVD 211

  Fly   159 LEMEPRSVEKPAYDDPTSDFEDEDSLDNLPLYNRIQKWKTGRKSVYKCHDCPRSFKRFDFLKRHE 223
            :.      |||....|...:.:..|  :|.|:.||.   ||.|. |||:.|.:||.::..||.|:
  Rat   212 MG------EKPHQCGPCRKYINTTS--SLSLHQRIH---TGEKP-YKCNICEKSFNQWSRLKTHQ 264

  Fly   224 MRVHKPETRLYDCSLCIRKFSRSEALEAHLKIHRNSKRSANISEHKKAKAVDLNLCKPHGYKLIE 288
            : :|..| :.|.|......|.:..|.::|.:.|.                         |.|..:
  Rat   265 I-LHISE-KQYKCKEGRMSFVQVFAHKSHQRRHT-------------------------GEKPYK 302

  Fly   289 CMICQSQYNKIADLRRHLEEH-PDIVSLCGRPNMEPHELAELFYPDSKDLSEEQLINLIRKDLAA 352
            |..|...:...|.||.|.:.| |::...|........||:.|
  Rat   303 CKECDRSFAHCASLRWHQKIHSPEVHYECKECGKAFSELSHL----------------------- 344

  Fly   353 GIYQRFYSITNQSGYEMDLDSSETDSDLDGDHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDH 417
            .::.|.:::.....|| :.|:|.|.:....:|...|.|.|..|.......:.:..:.|.||
  Rat   345 KMHYRIHTVEKPYRYE-ECDTSSTVNSTLKNHQKIHTREKPYRYRECDKSITKCSYLRTYQ---- 404

  Fly   418 QRQSHSWSDAPHVCGRCDGRFVSLQLLRHHNE-------SQCRNAQKRFLCHKCPLRFRWKHNLK 475
              :.|: ...|:.|..||..|.:...||.|.:       ..|:.:.|.|| ....:|   ||. |
  Rat   405 --RVHT-GMRPYRCTECDKSFTTYSNLRQHQKIHTGEKPPNCKGSDKSFL-RISSVR---KHQ-K 461

  Fly   476 THFREHRITNQTFECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRH 540
            .|..|.|     :.|.||.|.|....:|.|| ..||..| :...|:.|.:.|.....|..|.|.|
  Rat   462 IHAGERR-----YGCKECSRSFTWFSNLRVH-QRVHTGE-RPYRCKDCDKSFTTGSNLRVHQKIH 519

  Fly   541 GLKEHDIPLAETLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNY 605
                                .|.|...|:.|::.|..|.:||.|.::.
  Rat   520 --------------------TGEKPYKCKDCDISFLWISNLRTHQKIH----------------- 547

  Fly   606 SITNESGFELQLEDSETEDEMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDD 670
                                    .|.:| |.|:    :||:.|....:.|
  Rat   548 ------------------------TGEKP-YKCQ----ECKKSFTRCSYLR-------------- 569

  Fly   671 CIFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQG 735
                       ||.:   ..:.||.:.|..|:..|||..:|.:|..:.         ||::.
  Rat   570 -----------DHQK---IHTGEKLYKCKDCNVSFMWISSLRRHQKIH---------TGEKP--- 608

  Fly   736 TGDLEKDATEDGIPLLQCPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSA 800
                           .:|..|::::...|.|    ||
  Rat   609 ---------------YKCRECEKSFTQCSTL----RD---------------------------- 626

  Fly   801 AALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLT 865
                 |.:.||||||:||..|:::|...|.|..|:::||||||:.|.|||..|.....||.|...
  Rat   627 -----HQKIHTGEKPYKCKDCDISFLWISSLRRHQKIHTGEKPYKCKVCGISFLWISNLKTHQKI 686

  Fly   866 HSGLKPHKCTYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHR 919
            |:|.||:||..|.||:.:...|::|.:.||||.|:.|..||..|:..|.|.:|:
  Rat   687 HTGEKPYKCQECNKSFTRCSYLRVHQKTHTGEKPYKCKDCGVSFMWISNLRRHQ 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	6/29 (21%)
		C2H2 Zn finger	206..227	CDD:275368	7/20 (35%)
		C2H2 Zn finger	236..256	CDD:275368	4/19 (21%)
		C2H2 Zn finger	401..422	CDD:275368	3/20 (15%)
		C2H2 Zn finger	431..447	CDD:275368	6/15 (40%)
		C2H2 Zn finger	461..481	CDD:275368	5/19 (26%)
		C2H2 Zn finger	490..511	CDD:275368	8/20 (40%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	668..690	CDD:275368	2/21 (10%)
		C2H2 Zn finger	698..715	CDD:275368	6/16 (38%)
		C2H2 Zn finger	753..774	CDD:275368	6/20 (30%)
		C2H2 Zn finger	790..810	CDD:275368	1/19 (5%)
		zf-H2C2_2	802..825	CDD:290200	10/22 (45%)
		COG5048	814..>886	CDD:227381	32/71 (45%)
		C2H2 Zn finger	818..838	CDD:275368	6/19 (32%)
		zf-H2C2_2	830..855	CDD:290200	13/24 (54%)
		C2H2 Zn finger	846..866	CDD:275368	8/19 (42%)
		zf-H2C2_2	859..883	CDD:290200	12/23 (52%)
		C2H2 Zn finger	874..894	CDD:275368	6/19 (32%)
		C2H2 Zn finger	902..924	CDD:275368	7/18 (39%)
Zfp52	NP_001014180.1	KRAB	44..84	CDD:396083
		C2H2 Zn finger	219..239	CDD:275368	5/21 (24%)
		SFP1	<241..324	CDD:227516	27/110 (25%)
		C2H2 Zn finger	247..295	CDD:275368	14/49 (29%)
		C2H2 Zn finger	303..323	CDD:275368	6/19 (32%)
		COG5048	329..702	CDD:227381	128/573 (22%)
		C2H2 Zn finger	331..351	CDD:275368	5/42 (12%)
		C2H2 Zn finger	359..379	CDD:275368	6/20 (30%)
		C2H2 Zn finger	388..407	CDD:275368	3/24 (13%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		C2H2 Zn finger	443..463	CDD:275370	8/24 (33%)
		C2H2 Zn finger	471..491	CDD:275368	8/20 (40%)
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		C2H2 Zn finger	555..575	CDD:275368	7/51 (14%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		C2H2 Zn finger	611..631	CDD:275368	7/56 (13%)
		C2H2 Zn finger	639..659	CDD:275368	6/19 (32%)
		C2H2 Zn finger	667..687	CDD:275368	8/19 (42%)
		C2H2 Zn finger	695..715	CDD:275368	6/19 (32%)
		zf-H2C2_2	707..730	CDD:404364	10/22 (45%)
		C2H2 Zn finger	723..743	CDD:275368	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336942
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45252
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940