DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG18476 and ZNF445

DIOPT Version :10

Sequence 1:NP_731615.1 Gene:CG18476 / 41404 FlyBaseID:FBgn0037931 Length:936 Species:Drosophila melanogaster
Sequence 2:NP_852466.1 Gene:ZNF445 / 353274 HGNCID:21018 Length:1031 Species:Homo sapiens


Alignment Length:966 Identity:188/966 - (19%)
Similarity:299/966 - (30%) Gaps:424/966 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   137 PDETDMESKK-----SVDPLTMIETVKL-----------------EMEPRSVEKPAYDDP----- 174
            |...|::||.     :.:||...||:.:                 ..:.:|.:|...::|     
Human   309 PTGDDLQSKTNKFILNQEPLEEAETLAVSSGCPATSVSEGIGLRESFQQKSRQKDQCENPIQVRV 373

  Fly   175 -------------TSDFEDEDSLD-NLPLYNRIQKWKTGRKSVYKCHDCPRSFK----RFDFLK- 220
                         .|:....:||| ....|.|:    :|||...| |.|.:.|:    .:|:.| 
Human   374 KKEETNFSHRTGKDSEVSGSNSLDLKHVTYLRV----SGRKESLK-HGCGKHFRMSSHHYDYKKY 433

  Fly   221 ----RH-------EMRVH---KPETR------------------------LYDCSLCIRKFSRSE 247
                ||       ..|:|   |...:                        .:.||.|.|.||.|.
Human   434 GKGLRHMIGGFSLHQRIHSGLKGNKKDVCGKDFSLSSHHQRGQSLHTVGVSFKCSDCGRTFSHSS 498

  Fly   248 ALEAHLKIHRNSKR------------SANISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIA 300
            .|..|.::|...|.            |:|.:.|:|...         |.|..:|.:|:..:.:::
Human   499 HLAYHQRLHTQEKAFKCRVCGKAFRWSSNCARHEKIHT---------GVKPYKCDLCEKAFRRLS 554

  Fly   301 DLRRHLEEHPDIVSLCGRPNMEPHELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQS 365
            ..|.|.|.|..                                   :|.|....|:.  ::|..|
Human   555 AYRLHRETHAK-----------------------------------KKFLELNQYRA--ALTYSS 582

  Fly   366 GYEMDLDSSETDSDLDGDHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHV 430
            |::..|          ||         :|.:..:.|..|::.|..|..:.:|||           
Human   583 GFDHHL----------GD---------QSGEKLFDCSQCRKSFHCKSYVLEHQR----------- 617

  Fly   431 CGRCDGRFVSLQLLRHHNESQCRNAQKRFLCHKCPLRFRWKHNLKTHFREHR------------- 482
                                 ....:|.:.|.||...|||:.|...|.|.|.             
Human   618 ---------------------IHTQEKPYKCTKCRKTFRWRSNFTRHMRLHEEEKFYKQDECREG 661

  Fly   483 --------------ITNQTFECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKF-YRHDY 532
                          ...:||.|.:|.:.|.:||:|..| ..:|..| |...|..|.:.| ||..:
Human   662 FRQSPDCSQPQGAPAVEKTFLCQQCGKTFTRKKTLVDH-QRIHTGE-KPYQCSDCGKDFAYRSAF 724

  Fly   533 LVKHLKRHGLKEHDIPLAETLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQ 597
            :| |.|:|.:|.              :|.|..                                 
Human   725 IV-HKKKHAMKR--------------KPEGGP--------------------------------- 741

  Fly   598 SYDSPHNYSITNESGFELQLEDSETEDEMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFD 662
                    |.:.::.|::. :.|.:::|         .|.|..|....:....::.||| :|   
Human   742 --------SFSQDTVFQVP-QSSHSKEE---------PYKCSQCGKAFRNHSFLLIHQR-VH--- 784

  Fly   663 KMPHECDDCIFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNP 727
                                        :.||.:.|.:|...|.|..||.:|             
Human   785 ----------------------------TGEKPYKCRECGKAFRWSSNLYRH------------- 808

  Fly   728 TGDRHTQGTGDLEKDATEDGIPLLQCPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSL 792
                  |....|:|.        ..|...::|..::.::        :.|:       |||.|..
Human   809 ------QRIHSLQKQ--------YDCHESEKTPNVEPKI--------LTGE-------KRFWCQE 844

  Fly   793 CGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSD 857
            ||........|:.|...|:|||.:||:||..::.|:..|.:|:|:|:.|:||.|..|||:|....
Human   845 CGKTFTRKRTLLDHKGIHSGEKRYKCNLCGKSYDRNYRLVNHQRIHSTERPFKCQWCGKEFIGRH 909

  Fly   858 KLKRHMLTHS------------------------------------------------------G 868
            .|..|...|:                                                      |
Human   910 TLSSHQRKHTRAAQAERSPPARSSSQDTKLRLQKLKPSEEMPLEDCKEACSQSSRLTGLQDISIG 974

  Fly   869 LKPHKCTYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHRLMRRH 924
            .|.|||:.|.|::.::..|..|.:.||.|.||.|..||:.|..||.|.:|  |:.|
Human   975 KKCHKCSICGKTFNKSSQLISHKRFHTRERPFKCSKCGKTFRWSSNLARH--MKNH 1028

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18476NP_731615.1 C2H2 Zn finger 206..227 CDD:275368 8/36 (22%)
C2H2 Zn finger 236..256 CDD:275368 9/19 (47%)
C2H2 Zn finger 401..422 CDD:275368 7/20 (35%)
C2H2 Zn finger 431..447 CDD:275368 0/15 (0%)
C2H2 Zn finger 461..481 CDD:275368 9/19 (47%)
C2H2 Zn finger 490..511 CDD:275368 7/20 (35%)
C2H2 Zn finger 520..540 CDD:275368 8/20 (40%)
C2H2 Zn finger 638..659 CDD:275368 5/20 (25%)
C2H2 Zn finger 668..690 CDD:275368 0/21 (0%)
C2H2 Zn finger 698..715 CDD:275368 6/16 (38%)
C2H2 Zn finger 753..774 CDD:275368 2/20 (10%)
C2H2 Zn finger 790..810 CDD:275368 5/19 (26%)
COG5048 814..>886 CDD:227381 28/125 (22%)
C2H2 Zn finger 818..838 CDD:275368 7/19 (37%)
C2H2 Zn finger 846..866 CDD:275368 7/19 (37%)
C2H2 Zn finger 874..894 CDD:275368 5/19 (26%)
C2H2 Zn finger 902..924 CDD:275368 9/21 (43%)
ZNF445NP_852466.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43
SCAN 51..155 CDD:128708
KRAB 234..292 CDD:214630
C2H2 Zn finger 415..451 CDD:275368 8/35 (23%)
COG5048 <457..643 CDD:227381 48/282 (17%)
C2H2 Zn finger 460..479 CDD:275368 0/18 (0%)
C2H2 Zn finger 487..507 CDD:275368 9/19 (47%)
C2H2 Zn finger 515..535 CDD:275368 4/19 (21%)
C2H2 Zn finger 543..563 CDD:275368 5/19 (26%)
COG5048 595..1031 CDD:227381 124/610 (20%)
C2H2 Zn finger 599..619 CDD:275368 7/51 (14%)
C2H2 Zn finger 627..647 CDD:275368 9/19 (47%)
C2H2 Zn finger 683..703 CDD:275368 7/20 (35%)
C2H2 Zn finger 711..731 CDD:275368 8/20 (40%)
C2H2 Zn finger 764..784 CDD:275368 5/20 (25%)
C2H2 Zn finger 792..812 CDD:275368 8/38 (21%)
C2H2 Zn finger 842..862 CDD:275368 5/19 (26%)
C2H2 Zn finger 870..890 CDD:275368 7/19 (37%)
C2H2 Zn finger 898..918 CDD:275368 7/19 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 911..939 3/27 (11%)
C2H2 Zn finger 953..972 CDD:275368 0/18 (0%)
C2H2 Zn finger 980..1000 CDD:275368 5/19 (26%)
C2H2 Zn finger 1008..1028 CDD:275368 9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.