DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and ZNF850

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001180481.1	Gene:	ZNF850 / 342892	HGNCID:	27994	Length:	1090	Species:	Homo sapiens

Alignment Length:	966	Identity:	252/966 - (26%)
Similarity:	371/966 - (38%)	Gaps:	194/966 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DKLLSEILC-------ELTEINLDATGSQKFPQCLCSGCTKKLMGAYCYVK-------------- 73
            :||.....|       |||:.....||.:.:.   |..|.|........||
Human   167 EKLYKSTECMAFKYGSELTQQQETHTGEKLYK---CKECGKAFHHFSYLVKHQRIHTGEKPCACK 228

  Fly    74 ---QAMAANELLMKHLKNGAAPTSTDCLQEAPMELCAEQHV--EVKLETED-----EDCGE---N 125
               :|..:...|::|.|........:| ||:........|:  ..::.|.|     ::||:   :
Human   229 EYGKAFISGSHLIQHQKMYTDERPHEC-QESVKAFRPSAHLIQHWRIHTGDKPYECKECGKSFTS 292

  Fly   126 DVTITCSELPEPDETDMESKKSVDPLTMIETVKLEMEPRSVEKPAYD--DPTSDFEDEDSLDNLP 188
            ..|:...:.....|.....|:.....|:..|:....:..:.||| ||  :....|....:|
Human   293 GSTLNQHQQIHTGEKPYHCKQCGKSFTVGSTLIRHQQIHTGEKP-YDCKECGKSFASGSAL---- 352

  Fly   189 LYNRIQKWKTGRKSVYKCHDCPRSFKRFDFLKRHEMRVHKPETRLYDCSLCIRKFSRSEALEAHL 253
              .|.|:..||.|. |.|.:|.:||.....|.||: |:|..| :.|||..|.:.|:....|..|.
Human   353 --IRHQRIHTGEKP-YDCKECGKSFTFHSALIRHQ-RIHTGE-KPYDCKECGKSFTFRSGLIGHQ 412

  Fly   254 KIHRNSK------------RSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIADL---- 302
            .||...|            ..:.:.:|::...         |.|..:|..|...:...:.|
Human   413 AIHTGEKPYDCKECGKSFTAGSTLIQHQRIHT---------GEKPYDCKECGKSFASGSALLQHQ 468

  Fly   303 RRHLEEHPDIVSLCG-----RPNMEPHE---LAELFYPDSKDLSEEQLINLIRKDLAAGI----Y 355
            |.|..|.|.....||     |.....|:   ..|..| :.|:..         |..|:|.    :
Human   469 RIHTGEKPYCCKECGKSFTFRSTRNRHQRIHTGEKPY-NCKECG---------KSFASGSALLQH 523

  Fly   356 QRFYSITNQSGYE-MDLDSSET-DSDLDGDHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQ 418
            ||.:  |.:..|. .:...|.| .|.|.| |...|...|     .|.|:.|.:.|..:..|..||
Human   524 QRIH--TGEKPYHCKECGKSFTFRSGLIG-HQAVHTGEK-----PYDCKECGKSFTSRSALIQHQ 580

  Fly   419 RQSHSWSDAPHVCGRCDGRF-VSLQLLRHHNESQCRNAQKRFLCHKCPLRFRWKHNLKTHFREHR 482
            | .|: .:.|:.|..|...| |...||:|   .|....:|.:.|.:|...||.:..|..|.:.|
Human   581 R-IHT-GEKPYHCKECGKSFTVGSTLLQH---QQIHTGEKPYDCKECGKAFRLRLRLTQHQQIH- 639

  Fly   483 ITNQTFECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRHGLKEHDI 547
            ...:.::|.||.:.|.....||.| ..:|..| |...|..|.:.|.:..||.:|.:.|
Human   640 TGEKPYQCQECGKAFVSVSGLTQH-HRIHTGE-KPYECPDCGKAFRQRTYLNQHRRIH------- 695

  Fly   548 PLAETLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPH-NYSITNES 611
                         .|.|...|:.|...|.....|..|.|     :.:..:.||... ..|.|:.|
Human   696 -------------TGEKPYECKECGKSFTFCSGLIQHQQ-----NHTDEKPYDGKECGKSFTSHS 742

  Fly   612 GFELQLEDSETEDEMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCV 676
            .. :|.:...|        |.:| |.|:.|.........:||||: :|..:|: ::|.:|.....
Human   743 TL-IQHQQIHT--------GEKP-YDCKECGKSFTSHSTLIQHQQ-IHTGEKL-YDCKECGKSFT 795

  Fly   677 SKSIMDHHRQGQCSSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEK 741
            |.|.:..|:  ...:.||.:.|.:|...|.....|.||           .|.   ||
Human   796 SHSTLIQHQ--PLHTGEKPYHCKECGKSFTLRSALIQH-----------RPV---HT-------- 836

  Fly   742 DATEDGIPLLQCPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTH 806
                 |.....|..|.:::..:|.|..|.| :| .|:       |.:.|..||......:|::.|
Human   837 -----GEKRYSCKECGKSFTSRSTLIEHQR-IH-TGE-------KPYHCKECGKSFAFRSAIIQH 887

  Fly   807 MRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKP 871
            .|.||||||:.|..|..||.|.|:|..|:|:||||||:.|..|||.|.|...|.:|...|:|.||
Human   888 RRIHTGEKPYDCKECGKAFRRRSKLTQHQRIHTGEKPYRCHECGKAFVRFSGLTKHHSIHTGEKP 952

  Fly   872 HKCTYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHRLMRRHFDE 927
            ::|..|.||:||...|.||.:.|||:.|:.|..||:.|...|.|.:|:  |.|..|
Human   953 YECKTCGKSFRQRTHLTLHQRIHTGDRPYECKECGKSFTCGSELIRHQ--RTHTGE 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	15/77 (19%)
		C2H2 Zn finger	206..227	CDD:275368	8/20 (40%)
		C2H2 Zn finger	236..256	CDD:275368	5/19 (26%)
		C2H2 Zn finger	401..422	CDD:275368	7/20 (35%)
		C2H2 Zn finger	431..447	CDD:275368	6/16 (38%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	490..511	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..659	CDD:275368	6/20 (30%)
		C2H2 Zn finger	668..690	CDD:275368	5/21 (24%)
		C2H2 Zn finger	698..715	CDD:275368	5/16 (31%)
		C2H2 Zn finger	753..774	CDD:275368	6/20 (30%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		zf-H2C2_2	802..825	CDD:290200	11/22 (50%)
		COG5048	814..>886	CDD:227381	35/71 (49%)
		C2H2 Zn finger	818..838	CDD:275368	9/19 (47%)
		zf-H2C2_2	830..855	CDD:290200	14/24 (58%)
		C2H2 Zn finger	846..866	CDD:275368	8/19 (42%)
		zf-H2C2_2	859..883	CDD:290200	10/23 (43%)
		C2H2 Zn finger	874..894	CDD:275368	9/19 (47%)
		C2H2 Zn finger	902..924	CDD:275368	8/21 (38%)
ZNF850	NP_001180481.1	KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		C2H2 Zn finger	199..219	CDD:275368	5/19 (26%)
		C2H2 Zn finger	227..244	CDD:275368	2/16 (13%)
		COG5048	243..659	CDD:227381	110/459 (24%)
		C2H2 Zn finger	255..275	CDD:275368	4/20 (20%)
		C2H2 Zn finger	283..303	CDD:275368	3/19 (16%)
		zf-H2C2_2	296..319	CDD:290200	2/22 (9%)
		C2H2 Zn finger	311..331	CDD:275368	3/19 (16%)
		zf-H2C2_2	324..348	CDD:290200	6/24 (25%)
		C2H2 Zn finger	339..359	CDD:275368	4/25 (16%)
		zf-H2C2_2	351..375	CDD:290200	10/30 (33%)
		C2H2 Zn finger	367..387	CDD:275368	8/20 (40%)
		zf-H2C2_2	379..403	CDD:290200	10/25 (40%)
		C2H2 Zn finger	395..415	CDD:275368	5/19 (26%)
		C2H2 Zn finger	423..443	CDD:275368	1/19 (5%)
		zf-H2C2_2	436..460	CDD:290200	5/32 (16%)
		C2H2 Zn finger	451..471	CDD:275368	4/19 (21%)
		zf-H2C2_2	463..487	CDD:290200	7/23 (30%)
		C2H2 Zn finger	479..499	CDD:275368	4/19 (21%)
		zf-H2C2_2	493..516	CDD:290200	5/32 (16%)
		C2H2 Zn finger	507..527	CDD:275368	6/28 (21%)
		zf-H2C2_2	519..543	CDD:290200	5/25 (20%)
		COG5048	531..947	CDD:227381	139/504 (28%)
		C2H2 Zn finger	535..555	CDD:275368	6/20 (30%)
		C2H2 Zn finger	563..583	CDD:275368	7/20 (35%)
		zf-H2C2_2	575..599	CDD:290200	8/25 (32%)
		C2H2 Zn finger	591..611	CDD:275368	8/22 (36%)
		C2H2 Zn finger	619..639	CDD:275368	6/19 (32%)
		zf-H2C2_2	632..656	CDD:290200	7/24 (29%)
		C2H2 Zn finger	647..667	CDD:275368	7/20 (35%)
		zf-H2C2_2	660..684	CDD:290200	9/25 (36%)
		C2H2 Zn finger	675..695	CDD:275368	6/19 (32%)
		zf-H2C2_2	687..711	CDD:290200	8/43 (19%)
		C2H2 Zn finger	703..723	CDD:275368	6/24 (25%)
		C2H2 Zn finger	732..751	CDD:275368	4/19 (21%)
		C2H2 Zn finger	759..779	CDD:275368	6/20 (30%)
		C2H2 Zn finger	787..807	CDD:275368	5/21 (24%)
		C2H2 Zn finger	815..835	CDD:275368	7/33 (21%)
		C2H2 Zn finger	843..863	CDD:275368	6/20 (30%)
		zf-H2C2_2	856..879	CDD:290200	9/31 (29%)
		C2H2 Zn finger	871..891	CDD:275368	6/19 (32%)
		C2H2 Zn finger	899..919	CDD:275368	9/19 (47%)
		zf-H2C2_2	912..936	CDD:290200	14/23 (61%)
		C2H2 Zn finger	927..947	CDD:275368	8/19 (42%)
		C2H2 Zn finger	955..975	CDD:275368	9/19 (47%)
		zf-H2C2_2	967..992	CDD:290200	11/24 (46%)
		C2H2 Zn finger	983..1003	CDD:275368	8/21 (38%)
		zf-H2C2_2	995..1020	CDD:290200	5/14 (36%)
		C2H2 Zn finger	1011..1031	CDD:275368
		zf-H2C2_2	1024..1046	CDD:290200
		C2H2 Zn finger	1039..1059	CDD:275368
		zf-H2C2_2	1052..1076	CDD:290200
		C2H2 Zn finger	1067..1087	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010