DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and Zfp142

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_038939601.1	Gene:	Zfp142 / 316524	RGDID:	1309648	Length:	1859	Species:	Rattus norvegicus

Alignment Length:	993	Identity:	219/993 - (22%)
Similarity:	338/993 - (34%)	Gaps:	299/993 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 AAPTSTDCLQEAP-MELCAEQHVEVKLETEDEDCGENDVTITCSELPEPDETDMES--------- 144
            :|.||....:|.| :|..|.:.....|.:| |.......|:|...:|.|...:.||
  Rat   966 SAGTSALVAEEEPLLEKLASEPPRNPLISE-EAPNTFKATLTAETVPLPQVPESESLLKAMRRQD 1029

  Fly   145 KKSVDPLTM---IETVKLEMEPRSVEKPAYDDPTSDFEDEDSLDNLPLYNRIQKWKT-------- 198
            |:..:.|.:   ::.|.::.|.|:...|                :.|...|.:|..|
  Rat  1030 KEQAEALVLEGRVQMVVIQGEGRAFRCP----------------HCPFITRREKALTLHSKSGCQ 1078

  Fly   199 GRKSVYKCHDCPRSFKRFDFLKRHEMRVHKPETRLYDCSLCIRKFSRSEALEAHLK--IHRN--S 259
            ||:....|.:|..|||:...|..|.::         .|.:.:|| :::.||...:.  :|..  |
  Rat  1079 GRREPLLCPECGASFKQQRGLSTHMLK---------KCPVLLRK-NKALALPKPVSPTLHPELPS 1133

  Fly   260 KRSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIADLRRHLEEHPDIVSLCGRPNMEPH 324
            .:::..:|.:|         .|.....:|..|.:...::                |.|.|.:|.|
  Rat  1134 SQASQDAESRK---------PPPSPSKVELSISKDASSE----------------LPGEPGVEEH 1173

  Fly   325 ELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFY-------------------SITN------- 363
            ......:|.|..          ...|..|..::|:                   |||:
  Rat  1174 LPTPSDFPTSPP----------GNSLPTGTSEKFHFEQGKFHCNSCTFLCSRLSSITSHVTEGCR 1228

  Fly   364 ---------------------QSGYEMDLDSSETDSDLDGDHDDQHKRRKKSRKATYSCELCQQK 407
                                 .:|....|::..|||. .||.|....:::|.  ..|||..|...
  Rat  1229 GAHSQGRKRGRPQTHAVVLPLNNGDSTLLNTGSTDSS-PGDRDTAVVQKQKG--TLYSCPTCPFS 1290

  Fly   408 FPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRHH------------------------- 447
            ..::..|..||.|..........||.|.....:...||.|
  Rat  1291 CQQERTLKTHQTQGCPLEPGDLHCGLCPFTAPAPAALRLHQKRRHPTASPASGPRPLLQCGDCGF 1355

  Fly   448 --NESQCRNAQKRF-----LCHKCPL-------RFRWKHNLKTHFREHRITNQTFECSECKRVFD 498
              .:|:|....:|.     ..|:||.       |:|.:.:...|....||     .||.|.:.|.
  Rat  1356 TCKQSRCLQQHRRLKHEGVKPHQCPFCDFSTTRRYRLEAHQSRHTGVGRI-----PCSSCPQTFG 1415

  Fly   499 KKKSLTVHLLSVHAEESKLIPCQWCSRKFY-RHDYLVKHLKRHGLKEHDIPLAETLIAATSRPNG 562
            ....|.:|.|.|| :::....|..|....| |||     :.||               ..|...|
  Rat  1416 TNSKLRLHQLRVH-DKTPTHFCPLCDYSGYLRHD-----ITRH---------------VNSCHQG 1459

  Fly   563 AKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSETEDEMQ 627
            ....:|..|...|.....|:.|       :|..|   ..|     |..||..:.:.:.
  Rat  1460 TPSFSCSQCEAQFSSETALKQH-------ALRRH---PEP-----TPSSGCPVDVTEG------- 1502

  Fly   628 PGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPH-ECDDCIFKCVSKSIMDHHRQGQCSS 691
                  |:: |..|.:.|.....:..|.|..|     |. ||..|.....|:..:|.||:....|
  Rat  1503 ------PLH-CSHCGLLCPSPASLRGHTRKQH-----PRLECGACQESFPSRPALDEHRRQHHFS 1555

  Fly   692 TEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPHC 756
                |.|..||:.......|.:|.|.||.::|.:...||.               |.|.|.||.|
  Rat  1556 ----HRCQLCSFAARERVGLVKHYLEQHEETSTAPSDGDA---------------GQPSLCCPFC 1601

  Fly   757 DRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLC 821
            |...:.:..|::|::. | .|.|..|       |:.|...|::...:..|.|.||||||::|.||
  Rat  1602 DFACRHQLVLDHHVKG-H-GGTRLYK-------CTDCAYSTKNRQKITWHSRIHTGEKPYRCHLC 1657

  Fly   822 EMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCE-------- 878
            ..|....|.|..|.|:|..|:.:.|..||......::||.||..|:||||::|..||
  Rat  1658 SYACADPSRLKYHMRIHKEERKYLCPECGYKCKWVNQLKYHMTKHTGLKPYQCPECEYCTNRADA 1722

  Fly   879 ---------------------KSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHRLMR 922
                                 |:::....|:.||::|:...|:||..|...|..::.|..|.|..
  Rat  1723 LRVHRETRHKEARAFMCEQCGKAFKTRFLLRTHLRKHSEAKPYVCNVCHRAFRWAAGLRHHALTH 1787

  Fly   923 --RH--FDEVEAWLRRQK 936
              ||  |..:.::..:||
  Rat  1788 TDRHPFFCRLCSYKAKQK 1805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368	7/20 (35%)
		C2H2 Zn finger	236..256	CDD:275368	5/21 (24%)
		C2H2 Zn finger	401..422	CDD:275368	6/20 (30%)
		C2H2 Zn finger	431..447	CDD:275368	5/15 (33%)
		C2H2 Zn finger	461..481	CDD:275368	6/26 (23%)
		C2H2 Zn finger	490..511	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	6/20 (30%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	668..690	CDD:275368	6/21 (29%)
		C2H2 Zn finger	698..715	CDD:275368	4/16 (25%)
		C2H2 Zn finger	753..774	CDD:275368	6/20 (30%)
		C2H2 Zn finger	790..810	CDD:275368	5/19 (26%)
		zf-H2C2_2	802..825	CDD:290200	11/22 (50%)
		COG5048	814..>886	CDD:227381	28/100 (28%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	8/24 (33%)
		C2H2 Zn finger	846..866	CDD:275368	7/19 (37%)
		zf-H2C2_2	859..883	CDD:290200	13/52 (25%)
		C2H2 Zn finger	874..894	CDD:275368	7/48 (15%)
		C2H2 Zn finger	902..924	CDD:275368	6/23 (26%)
Zfp142	XP_038939601.1	COG5048	339..780	CDD:227381
		C2H2 Zn finger	364..384	CDD:275368
		C2H2 Zn finger	392..412	CDD:275368
		C2H2 Zn finger	420..437	CDD:275368
		C2H2 Zn finger	454..474	CDD:275368
		C2H2 Zn finger	520..539	CDD:275368
		C2H2 Zn finger	544..565	CDD:275368
		C2H2 Zn finger	573..594	CDD:275368
		zf-H2C2_5	600..624	CDD:404746
		C2H2 Zn finger	602..622	CDD:275368
		C2H2 Zn finger	630..650	CDD:275368
		C2H2 Zn finger	658..678	CDD:275368
		C2H2 Zn finger	686..706	CDD:275368
		C2H2 Zn finger	713..730	CDD:275368
		C2H2 Zn finger	1284..1313	CDD:275368	6/28 (21%)
		C2H2 Zn finger	1350..1371	CDD:275368	3/20 (15%)
		C2H2 Zn finger	1379..1399	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1407..1428	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1465..1486	CDD:275368	6/27 (22%)
		C2H2 Zn finger	1506..1524	CDD:275368	4/17 (24%)
		C2H2 Zn finger	1532..1552	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1598..1618	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1626..1646	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1654..1674	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1682..1702	CDD:275368	7/19 (37%)
		zf-H2C2_2	1695..1719	CDD:404364	12/23 (52%)
		C2H2 Zn finger	1710..1731	CDD:275368	3/20 (15%)
		C2H2 Zn finger	1739..1759	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1767..1787	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1795..1815	CDD:275368	2/11 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000