DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18476 and Zfp189

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001101400.1	Gene:	Zfp189 / 313219	RGDID:	1306510	Length:	608	Species:	Rattus norvegicus

Alignment Length:	642	Identity:	166/642 - (25%)
Similarity:	265/642 - (41%)	Gaps:	113/642 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 ICQSQYNKIAD---LRRHLEEHPDIVSLCGRPNMEPHEL------AELFYPDSKDLSEEQLINLI 346
            :....|.|:..   |.|:.:|.|.:.....: ::||..:      :||   |...:..|....:.
  Rat    28 VVMDSYGKLVSLDVLNRNEDEEPTVKEEIEK-DIEPQGIIVTRIKSEL---DQDPMGSETFELVG 88

  Fly   347 RKDLAAGIYQRFYSITNQSGYEMDLDSSETDSDLDGDHDDQHKRRKKSRKATYSCELCQQKFPRK 411
            |.|...||:.          :|:..||...:..:...|.:..||.....|. :.||.|.::|.||
  Rat    89 RLDKQRGIFL----------WEIPRDSLTEEQKMFRGHTNVRKRPNSEEKC-HKCEECGKRFVRK 142

  Fly   412 YQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRHHNESQCRNAQKRFLCHKCPLRFRWKHNLKT 476
            .....||| .|: .:.|..|..|...|.....:..|  .:....::.:.|:.|...|.....|..
  Rat   143 AHFIQHQR-VHT-GEKPFQCNECGKSFSRSSFVIEH--QRIHTGERPYECNYCGKTFSVSSTLIR 203

  Fly   477 HFREHRITNQTFECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRHG 541
            |.|.| ...:.::|::||:.|.:::||..| ..:|..| |...|..|.:.|....:|::|.:.|
  Rat   204 HQRIH-TGERPYQCNQCKQSFSQRRSLVKH-QRIHTGE-KPHKCSDCGKAFSWKSHLIEHQRTH- 264

  Fly   542 LKEHDIPLAETLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYS 606
                               .|.|...|..|...|.|...|..|.::         .:.:.||.
  Rat   265 -------------------TGEKPYHCTKCKKSFSRNSLLVEHQRI---------HTGERPHK-- 299

  Fly   607 ITNESGFELQLEDSETEDEMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDC 671
             ..|.|...:|.....:.: :...|.:| ::|..|.....|...:|:||| :|..:: |::|.:|
  Rat   300 -CGECGKAFRLSTYLIQHQ-KIHTGEKP-FLCIECGKSFSRSSFLIEHQR-IHTGER-PYQCQEC 359

  Fly   672 IFKCVSKS---IMDHHRQGQCSSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGD-RH 732
                 .||   :.:..|..:..:.:|.|.|.:|...|.....     |:||.:..:...|.. :.
  Rat   360 -----GKSFSQLCNLTRHQRIHTGDKPHKCEECGKAFSRSSG-----LIQHQRIHIREKTSPFKE 414

  Fly   733 TQGTGDLEKDATEDGIPLLQCPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMET 797
            |:|:.|               |:|....|         ::|:      .||  |.:.|..||...
  Rat   415 TKGSFD---------------PNCGLVIQ---------QEVY------PKE--KSYKCDDCGKTF 447

  Fly   798 RSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRH 862
            ..:|.||.|.|.||||||:.|.:|..:|.|.|.|..|:|:||||:|:.|..|||.|::...|.||
  Rat   448 SVSAHLVQHQRIHTGEKPYLCTVCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQLCNLIRH 512

  Fly   863 MLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHR 919
            ...|:|.|||||..|.|::.:...|..|.:.||||.|:.|..|.:.|.|..:|..|:
  Rat   513 QGVHTGNKPHKCEECGKAFSRNSGLIQHQRIHTGEKPYRCEKCDKSFSQQRSLVNHQ 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	401..422	CDD:275368	9/20 (45%)
		C2H2 Zn finger	431..447	CDD:275368	3/15 (20%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	490..511	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	638..659	CDD:275368	7/20 (35%)
		C2H2 Zn finger	668..690	CDD:275368	5/24 (21%)
		C2H2 Zn finger	698..715	CDD:275368	3/16 (19%)
		C2H2 Zn finger	753..774	CDD:275368	3/20 (15%)
		C2H2 Zn finger	790..810	CDD:275368	8/19 (42%)
		zf-H2C2_2	802..825	CDD:290200	12/22 (55%)
		COG5048	814..>886	CDD:227381	32/71 (45%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	13/24 (54%)
		C2H2 Zn finger	846..866	CDD:275368	8/19 (42%)
		zf-H2C2_2	859..883	CDD:290200	12/23 (52%)
		C2H2 Zn finger	874..894	CDD:275368	5/19 (26%)
		C2H2 Zn finger	902..924	CDD:275368	6/18 (33%)
Zfp189	NP_001101400.1	KRAB_A-box	<10..39	CDD:143639	2/10 (20%)
		COG5048	116..506	CDD:227381	122/475 (26%)
		C2H2 Zn finger	132..152	CDD:275368	9/20 (45%)
		zf-H2C2_2	144..169	CDD:290200	8/26 (31%)
		C2H2 Zn finger	160..180	CDD:275368	4/21 (19%)
		zf-H2C2_2	175..196	CDD:290200	3/22 (14%)
		C2H2 Zn finger	188..208	CDD:275368	6/19 (32%)
		zf-H2C2_2	201..225	CDD:290200	8/24 (33%)
		C2H2 Zn finger	216..236	CDD:275368	7/20 (35%)
		zf-H2C2_2	228..252	CDD:290200	8/25 (32%)
		C2H2 Zn finger	244..264	CDD:275368	5/19 (26%)
		zf-H2C2_2	256..281	CDD:290200	8/44 (18%)
		C2H2 Zn finger	272..292	CDD:275368	6/28 (21%)
		zf-H2C2_2	285..307	CDD:290200	6/33 (18%)
		C2H2 Zn finger	300..320	CDD:275368	3/20 (15%)
		zf-H2C2_2	312..337	CDD:290200	4/26 (15%)
		C2H2 Zn finger	328..348	CDD:275368	7/20 (35%)
		zf-H2C2_2	341..365	CDD:290200	10/30 (33%)
		C2H2 Zn finger	356..376	CDD:275368	5/24 (21%)
		zf-H2C2_2	368..393	CDD:290200	6/24 (25%)
		C2H2 Zn finger	384..404	CDD:275368	6/24 (25%)
		C2H2 Zn finger	440..460	CDD:275368	8/19 (42%)
		zf-H2C2_2	452..477	CDD:290200	13/24 (54%)
		C2H2 Zn finger	468..488	CDD:275368	8/19 (42%)
		zf-H2C2_2	481..505	CDD:290200	13/23 (57%)
		C2H2 Zn finger	496..516	CDD:275368	8/19 (42%)
		zf-H2C2_2	508..533	CDD:290200	12/24 (50%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	537..561	CDD:290200	10/23 (43%)
		C2H2 Zn finger	552..572	CDD:275368	6/18 (33%)
		C2H2 Zn finger	583..603	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910