DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG18476 and ZNF521

DIOPT Version :10

Sequence 1:NP_731615.1 Gene:CG18476 / 41404 FlyBaseID:FBgn0037931 Length:936 Species:Drosophila melanogaster
Sequence 2:NP_056276.1 Gene:ZNF521 / 25925 HGNCID:24605 Length:1311 Species:Homo sapiens


Alignment Length:1112 Identity:241/1112 - (21%)
Similarity:375/1112 - (33%) Gaps:355/1112 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   114 KLETEDEDCGENDVTITCSELPEP-DETDMESKKSVDPLTMI------------------ETVKL 159
            |||.:.|| ||   .:.|.:.||. :|.:.|:..|.|....:                  :.|.:
Human    18 KLEDKTED-GE---ALDCKKRPEDGEELEDEAVHSCDSCLQVFESLSDITEHKINQCQLTDGVDV 78

  Fly   160 EMEPR---SVEKPAYDDPTS-------DFEDEDSLDNLPLYNRIQKWKTGRKSVYKCHDCPRSFK 214
            |.:|.   ....|:..|.||       ||.:|:....||               |.|..|.:||.
Human    79 EDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLP---------------YPCQFCDKSFS 128

  Fly   215 RFDFLKRHE---------------------------MRVHKPETRLYDCSLCIRKFSRSEALEAH 252
            |..:||.||                           :::|..:.: |.||.|...||||:.|:.|
Human   129 RLSYLKHHEQSHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKK-YHCSECDAAFSRSDHLKIH 192

  Fly   253 LKIHRNSK-------RSANISE---------HKKAKAVDLNLCKPHGYKLIE---CMICQSQYNK 298
            ||.|.::|       |...:|.         |::.|....:..:...:|:.:   |..|:..::.
Human   193 LKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDGSQSGSRMEDWKMKDTQKCSQCEEGFDF 257

  Fly   299 IADLRRHLEE-HPDIVSLCGRPNMEPHELA-----ELFYPDSKDLSE-EQLINLIRKDLAAGIYQ 356
            ..||::|:.| ||:    |. ||.:...|.     |||..::..::. ||:.:..:|:..:...:
Human   258 PEDLQKHIAECHPE----CS-PNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSE 317

  Fly   357 RFYSI---------------TNQS--------GYEMDLDSSETDSDLDGDHD---------DQHK 389
            .|:::               .|.|        || ..:.|:..||:|..|..         .:.:
Human   318 SFHTVEELYSHMDSHQQPESCNHSNSPSLVTVGY-TSVSSTTPDSNLSVDSSTMVEAAPPIPKSR 381

  Fly   390 RRK--------------KSRKATYSCELC-QQKFPRKYQLYDHQRQSHSWSDAP---HVCGRCDG 436
            .||              |..|.||||..| :|.|.....|..|.:..|  .|.|   |:|..|..
Human   382 GRKRAAQQTPDMTGPSSKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMH--LDKPEQAHICQYCLE 444

  Fly   437 RFVSLQLLRHHNESQCRNAQKR-----------FLCHKCPLRFRWKHNLKTHFR-EHRITN---- 485
            ...||..|..|.: |...||..           :.|:.|.......:.|:.|.| .|...|    
Human   445 VLPSLYNLNEHLK-QVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFANPAAK 508

  Fly   486 --QTFECSECKRVFDKKKSLTVHLLSVHAEES-----------------KLIPCQWCSRK--FYR 529
              ..|.|..|...|....||..|:..||.:.|                 ::..|.:|:..  |..
Human   509 DSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNS 573

  Fly   530 HDYLVKHLK-------------RHGLKEHDI-PLAETLIAATS------------RPN------- 561
            ...|.||:|             .:|.|...: ||:...|..||            ||.       
Human   574 VLKLNKHIKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQ 638

  Fly   562 -GAK--------------------RITCRMCNLHFERIVDLRAHIQLELKLSLSLH--QSYDSPH 603
             |||                    ::||..||..|.....|..|:.:...::.:.:  :|.|.  
Human   639 CGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVTIHFMITSTYYICESCDK-- 701

  Fly   604 NYSITNESGFELQLEDSETEDEMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHEC 668
              ..|:....:..|.|..|          ...:.|.||......|..:..|....|..:|..:.|
Human   702 --QFTSVDDLQKHLLDMHT----------FVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRC 754

  Fly   669 DDCIFKCVSKSIMDHH-------RQG------------------QCSST--EKKHACGKCSYKFM 706
            ..|.:...:::.:..|       .||                  ||..|  .||:.|..||..|.
Human   755 TSCNWDFRNETDLQLHVKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFH 819

  Fly   707 WPENLEQHILLQHSKSSVSNP----------------------TGDRHTQGTGDLEKDATEDGIP 749
            ....||:|:..:|.......|                      |..:.:..:.|..::..:...|
Human   820 AIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQTLLTNSQESHNSHDGSEEDVDTSEP 884

  Fly   750 LLQCPHCDRTYQMKSRLNNH-IRDVHIN-GD----RKRKEAIK-RFLCSLCGMETRSAAALVTHM 807
            :..|..|...|.|::.|.|| :||.:|. |:    :|:.|.|| .:.|::|.....|...|..||
Human   885 MYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHM 949

  Fly   808 RRHTGE-KPFKCDLCEMAFPRHSELASHRRMH-----TGEKPFHCTVCGKDFARSDKLKRHMLTH 866
            :.|.|. |.:.|.:|...||....|..|:..|     ||    :|.:|.......::...|...|
Human   950 QTHLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTG----NCRICKMPLQSEEEFLEHCQMH 1010

  Fly   867 ----SGLKPHKCTYCEKSYRQAKDLKL----HLQ--------QHTGECPFV-----CGTCGERFI 910
                :.|...:|..|.::.....:||:    |:|        |.||....|     |.:|.:.|.
Human  1011 PDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFR 1075

  Fly   911 QSSTLEK 917
            ....|.|
Human  1076 SKQDLVK 1082

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18476NP_731615.1 C2H2 Zn finger 206..227 CDD:275368 9/47 (19%)
C2H2 Zn finger 236..256 CDD:275368 11/19 (58%)
C2H2 Zn finger 401..422 CDD:275368 6/21 (29%)
C2H2 Zn finger 431..447 CDD:275368 5/15 (33%)
C2H2 Zn finger 461..481 CDD:275368 5/20 (25%)
C2H2 Zn finger 490..511 CDD:275368 6/20 (30%)
C2H2 Zn finger 520..540 CDD:275368 7/34 (21%)
C2H2 Zn finger 638..659 CDD:275368 5/20 (25%)
C2H2 Zn finger 668..690 CDD:275368 6/46 (13%)
C2H2 Zn finger 698..715 CDD:275368 6/16 (38%)
C2H2 Zn finger 753..774 CDD:275368 9/21 (43%)
C2H2 Zn finger 790..810 CDD:275368 6/19 (32%)
COG5048 814..>886 CDD:227381 17/80 (21%)
C2H2 Zn finger 818..838 CDD:275368 6/19 (32%)
C2H2 Zn finger 846..866 CDD:275368 3/19 (16%)
C2H2 Zn finger 874..894 CDD:275368 6/31 (19%)
C2H2 Zn finger 902..924 CDD:275368 5/16 (31%)
ZNF521NP_056276.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37 9/22 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..108 6/26 (23%)
C2H2 Zn finger 120..140 CDD:275368 9/19 (47%)
COG5048 128..>216 CDD:227381 22/88 (25%)
C2H2 Zn finger 148..168 CDD:275368 0/19 (0%)
zf-H2C2_2 162..185 CDD:463886 6/23 (26%)
C2H2 Zn finger 176..196 CDD:275368 11/19 (58%)
C2H2 Zn finger 204..224 CDD:275368 2/19 (11%)
C2H2 Zn finger 248..265 CDD:275368 4/16 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 349..397 9/48 (19%)
C2H2 Zn finger 407..428 CDD:275368 6/20 (30%)
C2H2 Zn finger 439..460 CDD:275368 7/21 (33%)
C2H2 Zn finger 479..498 CDD:275368 4/18 (22%)
C2H2 Zn finger 636..656 CDD:275368 3/19 (16%)
C2H2 Zn finger 666..686 CDD:275368 6/19 (32%)
C2H2 Zn finger 696..713 CDD:275368 3/20 (15%)
C2H2 Zn finger 724..745 CDD:275368 5/20 (25%)
C2H2 Zn finger 754..774 CDD:275368 3/19 (16%)
C2H2 Zn finger 785..805 CDD:275368 3/19 (16%)
C2H2 Zn finger 811..829 CDD:275368 7/17 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..882 2/18 (11%)
C2H2 Zn finger 888..909 CDD:275368 8/20 (40%)
C2H2 Zn finger 932..952 CDD:275368 6/19 (32%)
C2H2 Zn finger 961..981 CDD:275368 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1168..1188
C2H2 Zn finger 1227..1247 CDD:275368
C2H2 Zn finger 1258..1279 CDD:275368
C2H2 Zn finger 1288..1307 CDD:275368
Blue background indicates that the domain is not in the aligned region.

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