Protein Alignment CG18476 and ZNF473

DIOPT Version :10

• Sequence 1: NP_731615.1
• Gene: CG18476 / 41404
• FlyBaseID: FBgn0037931
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: NP_056243.1
• Gene: ZNF473 / 25888
• HGNCID: 23239
• Length: 871
• Species: Homo sapiens
• Alignment Length: 922
• Identity: 217/922 - (23%)
• Similarity: 333/922 - (36%)
• Gaps: 294/922 - (31%)

  Fly   104 ELCAEQHVEVKLETEDEDCGENDVTITCSELPEPDETDMESKKSVDPLTMIETVKLEMEPRSVEK 168
            |.|.|......|..:.|....:|:. |..|.|...::. |.|:.:.|::.:.|.:..|.....||
Human   114 EACIEDTWLDSLLGDPESLLRSDIA-TNGESPTECKSH-ELKRGLSPVSTVSTGEDSMVHNVSEK 176

  Fly   169 ---PA----YDDPTSDFEDEDSLDNLPLYNRIQKWKTGRKSVYKCHDCPRSFKRFDFLKRH---- 222
               ||    |......:.|....|::         :.|.|. |:|.:|.:||.....|.:|
Human   177 TLTPAKSKEYRGEFFSYSDHSQQDSV---------QEGEKP-YQCSECGKSFSGSYRLTQHWITH 231

  Fly   223 ---EMRVHK---------------PET----RLYDCSLCIRKFSRSEALEAHLKIHRNSK----- 260
               :..||:               |:|    :.|.|:.....||:|..| .|.|.|...|
Human   232 TREKPTVHQECEQGFDRNASLSVYPKTHTGYKFYVCNEYGTTFSQSTYL-WHQKTHTGEKPCKSQ 295

  Fly   261 -------RSANISEHKK----AKAVDLNLC--------------KPHGYKLIECMICQSQYNKIA 300
                   ......||:|    :|:.:.|.|              |.|..|..||..||:.:|
Human   296 DSDHPPSHDTQPGEHQKTHTDSKSYNCNECGKAFTRIFHLTRHQKIHTRKRYECSKCQATFN--- 357

  Fly   301 DLRRHLEEHPDIVSLCGRPNMEPHELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQS 365
             ||:||.:|
Human   358 -LRKHLIQH-------------------------------------------------------- 365

  Fly   366 GYEMDLDSSETDSDLDGDHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHV 430
                                    ::..:.|.|..|:.|.:.|.....|.:|| ..|: .:.|:.
Human   366 ------------------------QKTHAAKTTSECQECGKIFRHSSLLIEHQ-ALHA-GEEPYK 404

  Fly   431 CGRCDGRFVSLQLLRHHNESQCRNAQKRFLCHKCPLRFRWKHNLKTHFREHRITNQTF---ECSE 492
            |......|.....|:.|  .:..:.:|.:.|.:|...|. :|   ||..|||..:..:   :|.|
Human   405 CNERGKSFRHNSTLKIH--QRVHSGEKPYKCSECGKAFH-RH---THLNEHRRIHTGYRPHKCQE 463

  Fly   493 CKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAAT 557
            |.|.|.:...|..| .::|..| |...|..|...|..::.||:|.|.|.:|
Human   464 CVRSFSRPSHLMRH-QAIHTAE-KPYSCAECKETFSDNNRLVQHQKMHTVK-------------- 512

  Fly   558 SRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFEL--QLEDS 620
                  ....|:.|.   ||.:         ...:|..|:|..:      ..:.||.:  ::.|.
Human   513 ------TPYECQECG---ERFI---------CGSTLKCHESVHA------REKQGFFVSGKILDQ 553

  Fly   621 ETEDEMQPGVGSRPVYICELCSVQCKRKFE----MIQHQRTMHRFDKMPHECDDCIFKCVSKS-- 679
            ..|.:.:          |..|: :|::.|.    :.||:| :|.....|.|||.| .|...:|
Human   554 NPEQKEK----------CFKCN-KCEKTFSCSKYLTQHER-IHTRGVKPFECDQC-GKAFGQSTR 605

  Fly   680 IMDHHR------------QGQCSST----------EKKH--ACGKCSYKFMWPENLEQHILLQHS 720
            ::.|.|            ||:..|:          .|:|  .|.:|...|....:|.:|.|:...
Human   606 LIHHQRIHSRVRLYKWGEQGKAISSASLIKLQSFHTKEHPFKCNECGKTFSHSAHLSKHQLIHAG 670

  Fly   721 KSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAI 785
            :    ||                       .:|..|||.:..::.|..|.|      ...||
Human   671 E----NP-----------------------FKCSKCDRVFTQRNYLVQHER------THARK--- 699

  Fly   786 KRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCG 850
            |..:|:.||...|.::.|..|.|.|:||||:.||.|..||...:||..|:|:||||||:.|..||
Human   700 KPLVCNECGKTFRQSSCLSKHQRIHSGEKPYVCDYCGKAFGLSAELVRHQRIHTGEKPYVCQECG 764

  Fly   851 KDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTL 915
            |.|.:|..|..|...|:|.||::|..|.|::.|..:|..|.:.||||.|:.|..||:.|:.|:.|
Human   765 KAFTQSSCLSIHRRVHTGEKPYRCGECGKAFAQKANLTQHQRIHTGEKPYSCNVCGKAFVLSAHL 829

  Fly   916 EKHRLMRRHFDE 927
            .:|  :|.|..|
Human   830 NQH--LRVHTQE 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	C2H2 Zn finger	206..227	CDD:275368	6/27 (22%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		C2H2 Zn finger	401..422	CDD:275368	6/20 (30%)
		C2H2 Zn finger	431..447	CDD:275368	3/15 (20%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	490..511	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	638..659	CDD:275368	7/24 (29%)
		C2H2 Zn finger	668..690	CDD:275368	9/35 (26%)
		C2H2 Zn finger	698..715	CDD:275368	4/16 (25%)
		C2H2 Zn finger	753..774	CDD:275368	7/20 (35%)
		C2H2 Zn finger	790..810	CDD:275368	7/19 (37%)
		COG5048	814..>886	CDD:227381	33/71 (46%)
		C2H2 Zn finger	818..838	CDD:275368	9/19 (47%)
		C2H2 Zn finger	846..866	CDD:275368	8/19 (42%)
		C2H2 Zn finger	874..894	CDD:275368	6/19 (32%)
		C2H2 Zn finger	902..924	CDD:275368	8/21 (38%)
ZNF473	NP_056243.1	KRAB_A-box	6..45	CDD:143639
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	47..81
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	140..164		5/24 (21%)
		COG5048	207..614	CDD:227381	112/553 (20%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		C2H2 Zn finger	239..259	CDD:275368	2/19 (11%)
		C2H2 Zn finger	267..286	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..318		4/27 (15%)
		Interaction with SLBP/pre-mRNA complex	312..552		69/371 (19%)
		C2H2 Zn finger	322..342	CDD:275368	3/19 (16%)
		C2H2 Zn finger	349..369	CDD:275368	9/103 (9%)
		C2H2 Zn finger	377..397	CDD:275368	6/20 (30%)
		C2H2 Zn finger	405..425	CDD:275368	4/21 (19%)
		C2H2 Zn finger	433..453	CDD:275368	9/23 (39%)
		COG5048	457..860	CDD:227381	130/474 (27%)
		C2H2 Zn finger	461..481	CDD:275368	7/20 (35%)
		C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		C2H2 Zn finger	517..537	CDD:275368	7/31 (23%)
		C2H2 Zn finger	564..584	CDD:275368	6/21 (29%)
		C2H2 Zn finger	593..613	CDD:275368	7/20 (35%)
		C2H2 Zn finger	648..668	CDD:275368	6/19 (32%)
		C2H2 Zn finger	676..696	CDD:275368	7/25 (28%)
		C2H2 Zn finger	704..724	CDD:275368	7/19 (37%)
		C2H2 Zn finger	732..752	CDD:275368	9/19 (47%)
		C2H2 Zn finger	760..780	CDD:275368	8/19 (42%)
		C2H2 Zn finger	788..808	CDD:275368	6/19 (32%)
		C2H2 Zn finger	816..836	CDD:275368	8/21 (38%)
		C2H2 Zn finger	844..864	CDD:275368