DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18476 and Zfp768

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_666314.1	Gene:	Zfp768 / 233890	MGIID:	2384582	Length:	568	Species:	Mus musculus

Alignment Length:	304	Identity:	104/304 - (34%)
Similarity:	146/304 - (48%)	Gaps:	31/304 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   629 GVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCVSKS--IMDHHRQGQCSS 691
            |.|.|| .||.:|.....|...:||||| :|..:| |::|:.| .|..|:|  ::.|.|   ..:
Mouse   283 GQGPRP-NICGICGKSFGRGSTLIQHQR-IHTGEK-PYKCEVC-SKAFSQSSDLIKHQR---THT 340

  Fly   692 TEKKHACGKCSYKFMWPENLEQHILLQHSKS-SVSNPTGDRHT-QGTGD----LEKDATEDGIPL 750
            .|:.:.|.:|...|     .:...||:|.:: |...|....|. :..||    |....|......
Mouse   341 GERPYKCPRCGKAF-----ADSSYLLRHQRTHSGQKPYKCPHCGKAFGDSSYLLRHQRTHSHERP 400

  Fly   751 LQCPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKP 815
            ..||.|.:.|...|.|.:|.| || .|.|.       |.|.:||......:||:.|.|.|..|||
Mouse   401 YSCPECGKCYSQNSSLRSHQR-VH-TGQRP-------FSCGICGKSFSQRSALIPHARSHAREKP 456

  Fly   816 FKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKS 880
            |||..|...|.:.|.||.|.|.|...:.:.|..|||.|.||..|.:|..:|:|.:|::|..|.|.
Mouse   457 FKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKTFNRSSTLIQHQRSHTGERPYRCAVCGKG 521

  Fly   881 YRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHRLMRRH 924
            :.::..|..|.:.|:||.|:.|..||:.|.|||.|.:|:  |.|
Mouse   522 FCRSSTLLQHHRVHSGERPYKCDDCGKAFSQSSDLIRHQ--RTH 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	401..422	CDD:275368
		C2H2 Zn finger	431..447	CDD:275368
		C2H2 Zn finger	461..481	CDD:275368
		C2H2 Zn finger	490..511	CDD:275368
		C2H2 Zn finger	520..540	CDD:275368
		C2H2 Zn finger	638..659	CDD:275368	8/20 (40%)
		C2H2 Zn finger	668..690	CDD:275368	7/23 (30%)
		C2H2 Zn finger	698..715	CDD:275368	3/16 (19%)
		C2H2 Zn finger	753..774	CDD:275368	8/20 (40%)
		C2H2 Zn finger	790..810	CDD:275368	7/19 (37%)
		zf-H2C2_2	802..825	CDD:290200	12/22 (55%)
		COG5048	814..>886	CDD:227381	28/71 (39%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	10/24 (42%)
		C2H2 Zn finger	846..866	CDD:275368	9/19 (47%)
		zf-H2C2_2	859..883	CDD:290200	8/23 (35%)
		C2H2 Zn finger	874..894	CDD:275368	5/19 (26%)
		C2H2 Zn finger	902..924	CDD:275368	10/21 (48%)
Zfp768	NP_666314.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..223
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..247
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..287		2/3 (67%)
		C2H2 Zn finger	291..311	CDD:275368	8/20 (40%)
		zf-H2C2_2	304..328	CDD:290200	11/26 (42%)
		C2H2 Zn finger	319..339	CDD:275368	7/23 (30%)
		COG5048	<327..532	CDD:227381	69/221 (31%)
		zf-H2C2_2	331..355	CDD:290200	6/31 (19%)
		C2H2 Zn finger	347..367	CDD:275368	6/24 (25%)
		zf-H2C2_2	359..382	CDD:290200	6/22 (27%)
		zf-C2H2	373..395	CDD:278523	4/21 (19%)
		C2H2 Zn finger	375..395	CDD:275368	4/19 (21%)
		zf-C2H2	401..423	CDD:278523	8/22 (36%)
		C2H2 Zn finger	403..423	CDD:275368	8/20 (40%)
		zf-H2C2_2	415..440	CDD:290200	11/33 (33%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		zf-H2C2_2	447..466	CDD:290200	10/18 (56%)
		C2H2 Zn finger	459..479	CDD:275368	8/19 (42%)
		zf-C2H2	485..507	CDD:278523	9/21 (43%)
		C2H2 Zn finger	487..507	CDD:275368	9/19 (47%)
		zf-H2C2_2	500..522	CDD:290200	8/21 (38%)
		C2H2 Zn finger	515..535	CDD:275368	5/19 (26%)
		zf-H2C2_2	528..552	CDD:290200	10/23 (43%)
		zf-C2H2	541..563	CDD:278523	10/23 (43%)
		C2H2 Zn finger	543..563	CDD:275368	10/21 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000