DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and Zfp418

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_666291.2	Gene:	Zfp418 / 232854	MGIID:	2444763	Length:	652	Species:	Mus musculus

Alignment Length:	902	Identity:	208/902 - (23%)
Similarity:	318/902 - (35%)	Gaps:	327/902 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 MAANELLMKHLKNGAAPTSTD----CLQ-------------EAPMELCAEQ----HVEVKL---- 115
            |||    :|||  ...|.||:    |:|             :...||..|.    :::|.|
Mouse     1 MAA----LKHL--AQVPRSTEKGMVCIQGCVTFEDVAVYFSQEEWELLDESQRLLYLDVMLENFT 59

  Fly   116 -----------ETEDEDCGENDVTITCSELP--EPDETDMESKKSVDPLTMIETVKLEMEPRSVE 167
                       |.||:.|.. .:......||  :|..:|:.|       |:::.: |.:.....:
Mouse    60 LITSLAHWSEAEAEDKTCAP-QIRTAKEGLPTKKPHPSDICS-------TVLKDI-LHLSDLPGQ 115

  Fly   168 KPAYDDPTSDFEDEDSLDNLPLYNRIQKWKTGRKSVYKCHDCPRSFKRFDFLKRHEMRVH---KP 229
            ||...:..:|..|:.       ::|.:.|.  :|.|             |.|.::.: .|   .|
Mouse   116 KPHLTEVCTDLLDQK-------HHRAKNWL--KKDV-------------DSLVKNCI-FHVAGNP 157

  Fly   230 ETRLYDCSLCIRKFS------RSEALEAHLKIHRNSKRSANISEHKKAKAVDLNLCKPHGYKLIE 288
            ..    ||....||.      :.:|:....|.::...|.|..||...:|:
Mouse   158 SV----CSKIGEKFPAVWNLLQPKAIPKGEKQNQIKCRKAFHSEKNNSKS--------------- 203

  Fly   289 CMICQSQYNKIADLRRHLEEHPDIVSLCGRPNMEPHELAELFYPDSKDLSEEQLINLIRKDLAAG 353
                 .:|||.:..:..|.|:|.:.|  |:...|.:             |.||.:|.
Mouse   204 -----DKYNKSSSPQHRLHEYPRLCS--GKEGFESN-------------SCEQDLNK-------- 240

  Fly   354 IYQRFYSITNQSGYEMDLDSSETDSDLDGDHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQ 418
                 |||.          .|:||               ::....|.|..|.:.|.:|..|..||
Mouse   241 -----YSIA----------PSQTD---------------QTENRPYGCHDCGKWFGQKATLRIHQ 275

  Fly   419 RQSHSWSDAPHVCGRCDGRFVSLQLLRHH-------NESQCRNAQKRFLCHKCPLRFRWKH---- 472
            |: |: .:.|:.||.|...|.....|..|       ...:|....|.|.||...||.:..|
Mouse   276 RR-HT-GEKPYRCGECGKSFCQSSNLSEHCRVHSGERPFECLECGKAFGCHSSLLRHQRTHTGEW 338

  Fly   473 ---------------NLKTHFREHRITNQTFECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQW 522
                           :|.||.|.| .|.:.:||.:|::.|..|.:|||| ..||..| |...|:.
Mouse   339 PYECGDCGRLFRQIVSLITHQRTH-TTEKPYECGQCEKSFSHKATLTVH-QRVHTGE-KPYHCEA 400

  Fly   523 CSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQL 587
            |.:.|.:...|:||.|.|
Mouse   401 CGKSFSQSANLIKHSKIH----------------------------------------------- 418

  Fly   588 ELKLSLSLHQSYDSPHNYSITNESGFELQLEDSETEDEMQPGVGSRPVYICELCSVQCKRKFEMI 652
                                                      .|.:| |.|..|.:..:::..::
Mouse   419 ------------------------------------------TGEKP-YKCGECGLCFRQRATLM 440

  Fly   653 QHQRTMHRFDKMPHECDDC--IFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYKFMWPENLEQHI 715
            :|||| |..:: |:||.:|  .||... .:::|.|   ..:|.:.:.||:|
Mouse   441 KHQRT-HTSER-PYECRECGKFFKQYF-YLIEHSR---IHTTTEFYECGQC-------------- 485

  Fly   716 LLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPHCDRTYQMKSRLNNHIRDVHINGDRK 780
                .||...|.|..||.:         ...|....:|..|.:.::.|||||.|.| .| .|:|.
Mouse   486 ----GKSYTQNATLIRHQR---------VHTGESPYKCKECGKAFEYKSRLNRHQR-TH-TGERP 535

  Fly   781 RKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFH 845
                   :.|:.||...|.:..|..|.:.||..||:.||.|...|.|.::|..|:|:||||:|:.
Mouse   536 -------YECAKCGKFFRESYNLAEHQKIHTKAKPYNCDQCGKCFSRRADLVKHQRVHTGERPYT 593

  Fly   846 CTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQHTGECPFVC 902
            |..|||.|:|:..|.:|...|:|.:|::|..|.||:.|...|..|...||||..:.|
Mouse   594 CGECGKTFSRTTNLVQHRRIHTGERPYECDQCGKSFSQVSTLTRHQLLHTGEKSYKC 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	3/7 (43%)
		C2H2 Zn finger	206..227	CDD:275368	2/20 (10%)
		C2H2 Zn finger	236..256	CDD:275368	6/25 (24%)
		C2H2 Zn finger	401..422	CDD:275368	8/20 (40%)
		C2H2 Zn finger	431..447	CDD:275368	5/15 (33%)
		C2H2 Zn finger	461..481	CDD:275368	9/38 (24%)
		C2H2 Zn finger	490..511	CDD:275368	8/20 (40%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	638..659	CDD:275368	6/20 (30%)
		C2H2 Zn finger	668..690	CDD:275368	6/23 (26%)
		C2H2 Zn finger	698..715	CDD:275368	3/16 (19%)
		C2H2 Zn finger	753..774	CDD:275368	9/20 (45%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		zf-H2C2_2	802..825	CDD:290200	9/22 (41%)
		COG5048	814..>886	CDD:227381	31/71 (44%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	13/24 (54%)
		C2H2 Zn finger	846..866	CDD:275368	8/19 (42%)
		zf-H2C2_2	859..883	CDD:290200	9/23 (39%)
		C2H2 Zn finger	874..894	CDD:275368	7/19 (37%)
		C2H2 Zn finger	902..924	CDD:275368	1/1 (100%)
Zfp418	NP_666291.2	KRAB	25..>66	CDD:214630	5/40 (13%)
		KRAB	25..64	CDD:279668	5/38 (13%)
		C2H2 Zn finger	258..278	CDD:275368	8/20 (40%)
		zf-H2C2_2	271..293	CDD:290200	9/23 (39%)
		COG5048	282..639	CDD:227381	123/491 (25%)
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		zf-H2C2_2	298..321	CDD:290200	4/22 (18%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		C2H2 Zn finger	342..362	CDD:275368	4/19 (21%)
		zf-H2C2_2	354..379	CDD:290200	10/25 (40%)
		C2H2 Zn finger	370..390	CDD:275368	8/20 (40%)
		zf-H2C2_2	383..407	CDD:290200	11/25 (44%)
		C2H2 Zn finger	398..418	CDD:275368	7/19 (37%)
		C2H2 Zn finger	426..446	CDD:275368	6/20 (30%)
		zf-H2C2_2	439..463	CDD:290200	10/25 (40%)
		C2H2 Zn finger	454..474	CDD:275368	6/23 (26%)
		C2H2 Zn finger	482..502	CDD:275368	9/46 (20%)
		zf-H2C2_2	495..519	CDD:290200	5/32 (16%)
		C2H2 Zn finger	510..530	CDD:275368	9/20 (45%)
		zf-H2C2_2	523..545	CDD:290200	10/30 (33%)
		C2H2 Zn finger	538..558	CDD:275368	6/19 (32%)
		C2H2 Zn finger	566..586	CDD:275368	8/19 (42%)
		zf-H2C2_2	578..603	CDD:290200	13/24 (54%)
		C2H2 Zn finger	594..614	CDD:275368	8/19 (42%)
		zf-H2C2_2	606..631	CDD:290200	9/24 (38%)
		C2H2 Zn finger	622..642	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000