DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and Zfp52

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_653098.2	Gene:	Zfp52 / 22710	MGIID:	99199	Length:	724	Species:	Mus musculus

Alignment Length:	885	Identity:	190/885 - (21%)
Similarity:	311/885 - (35%)	Gaps:	270/885 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 CLCSGCTKKLMGAYCYVKQAMAANEL--LMKHLKNGAAPTSTDCLQEAPMELCAEQHVEVKLETE 118
            |:|....:.:...    |::...|||  ::....|.|....:|..:.:....|
Mouse    56 CICDTVHQPVRTE----KESCPCNELNEMLHEPSNCALYNRSDTTEASNNYRC------------ 104

  Fly   119 DEDCGENDVTITCSELPE------PDETDMESKKSVDPLTMIETV----KLEMEPRSVEKPAYDD 173
               |.|.|.::..|....      .:|...:||.......:...:    :|..|.:..::..:||
Mouse   105 ---CNEKDASVDSSNADRHKSMHIGEEDTCQSKDCEKSFNLCSNIRQYQRLNTEKKEHKQDEHDD 166

  Fly   174 PTSDFEDEDSLDNLPLYNRIQKWKTGRKSVYKCHDCPRSFKRFDFLKRHEMRVHKPETRLYDCSL 238
            ..|.           ||:.:|:.....:..|:|..|.:.|.....|..|: |:|..| :.|.|::
Mouse   167 HFSS-----------LYSLMQETVDMEEKPYQCGHCRKYFSTTSSLSIHQ-RIHTGE-KPYKCNI 218

  Fly   239 CIRKFSRSEALEAHLKIHRNSKRSANISEHKKAKAVDLNLCKPH-----GYKLIECMICQSQYNK 298
            |.:.|::..:|:....:| .:|:.....|..|. .|.|:..|.|     |.|..:|..|...:..
Mouse   219 CGKSFNQWSSLKTDQTLH-TAKKPYKCKEGGKL-LVQLSALKSHQRRHTGEKPYKCQQCDRSFAH 281

  Fly   299 IADLRRHLEEH-PDI---VSLCGRPNMEPHELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFY 359
            .|.||.|.:.| |:|   ...||:...|                   |.:|.|       :.|.:
Mouse   282 CASLRWHQKIHSPEIHYECKECGKSCFE-------------------LSHLKR-------HCRIH 320

  Fly   360 SITNQSGYEMDLDSSETDSDLDGDHDDQHKRRKKSR-----------------------KATYSC 401
            :......||: .|:|.|.:.....|...|.|.|..|                       |..|.|
Mouse   321 TAEKPYRYEV-CDTSITVNSTLKTHHKIHTREKPYRYRECDKSITKCSYLRTYQRVHTGKRPYRC 384

  Fly   402 ELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRHHNESQCRNAQKRFLCHKCPL 466
            ..|.:.|.:...|..||: .|: .:.|..|..||..|:.:..:|...:...  .::|:.|.:|..
Mouse   385 TECDKFFTKHSNLRQHQK-IHT-GEKPPKCKDCDKSFLRISSVRIRQKIHA--GERRYRCKECGR 445

  Fly   467 RFRWKHNLKTHFREHRITNQTFECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHD 531
            .|.|..||:.|.|.| ...:.:.|.||.:.|....:|.|| ..:|
Mouse   446 SFTWFSNLRVHQRVH-TGERPYRCKECGKSFTTGSNLRVH-QKIH-------------------- 488

  Fly   532 YLVKHLKRHGLKEHDIPLAETLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLH 596
                                         .|.|...|:.|::.|..|.:||.|.::.
Mouse   489 -----------------------------TGEKPYKCKDCDISFLWISNLRTHQKIH-------- 516

  Fly   597 QSYDSPHNYSITNESGFELQLEDSETEDEMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRF 661
                                             .|.:| |.|:
Mouse   517 ---------------------------------TGEKP-YKCQ---------------------- 525

  Fly   662 DKMPHECDDCIFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSN 726
                 ||:....:|  ..:.||.:   ..:.||.:.|..|...|||..:|.:|..:.
Mouse   526 -----ECNKSFTRC--SYLRDHQK---IHTGEKLYKCKDCDISFMWISSLRRHQKIH-------- 572

  Fly   727 PTGDRHTQGTGDLEKDATEDGIPLLQCPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCS 791
             ||::.                  .:|..|::::...|.|.:| :.:| .|:       |.:.|.
Mouse   573 -TGEKP------------------YKCRGCEKSFTQCSTLRDH-QKIH-TGE-------KPYKCK 609

  Fly   792 LCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARS 856
            .||:.....::|..|.:.||||||:||..|:::|...|.|.:|:::||||||:.|..|.|.|.|.
Mouse   610 DCGISFLWISSLRRHQKIHTGEKPYKCKDCDISFLWISNLRTHQKIHTGEKPYKCQECNKSFTRC 674

  Fly   857 DKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQHTG 896
            ..|:.|..||||.|.:||..|:.|:....:|:.|.:.|||
Mouse   675 SYLRVHQRTHSGEKLYKCENCDVSFMWISNLRRHQKIHTG 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	6/29 (21%)
		C2H2 Zn finger	206..227	CDD:275368	6/20 (30%)
		C2H2 Zn finger	236..256	CDD:275368	4/19 (21%)
		C2H2 Zn finger	401..422	CDD:275368	6/20 (30%)
		C2H2 Zn finger	431..447	CDD:275368	5/15 (33%)
		C2H2 Zn finger	461..481	CDD:275368	8/19 (42%)
		C2H2 Zn finger	490..511	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	0/19 (0%)
		C2H2 Zn finger	638..659	CDD:275368	1/20 (5%)
		C2H2 Zn finger	668..690	CDD:275368	4/21 (19%)
		C2H2 Zn finger	698..715	CDD:275368	6/16 (38%)
		C2H2 Zn finger	753..774	CDD:275368	5/20 (25%)
		C2H2 Zn finger	790..810	CDD:275368	5/19 (26%)
		zf-H2C2_2	802..825	CDD:290200	11/22 (50%)
		COG5048	814..>886	CDD:227381	31/71 (44%)
		C2H2 Zn finger	818..838	CDD:275368	6/19 (32%)
		zf-H2C2_2	830..855	CDD:290200	12/24 (50%)
		C2H2 Zn finger	846..866	CDD:275368	7/19 (37%)
		zf-H2C2_2	859..883	CDD:290200	11/23 (48%)
		C2H2 Zn finger	874..894	CDD:275368	5/19 (26%)
		C2H2 Zn finger	902..924	CDD:275368
Zfp52	NP_653098.2	KRAB	12..52	CDD:366587
		C2H2 Zn finger	134..153	CDD:275368	1/18 (6%)
		COG5048	184..615	CDD:227381	123/626 (20%)
		C2H2 Zn finger	188..208	CDD:275368	6/20 (30%)
		C2H2 Zn finger	216..264	CDD:275368	12/49 (24%)
		C2H2 Zn finger	244..259	CDD:275368	4/15 (27%)
		C2H2 Zn finger	272..292	CDD:275368	6/19 (32%)
		C2H2 Zn finger	300..320	CDD:275368	7/45 (16%)
		C2H2 Zn finger	329..348	CDD:275368	5/19 (26%)
		C2H2 Zn finger	357..376	CDD:275368	0/18 (0%)
		C2H2 Zn finger	384..404	CDD:275368	6/20 (30%)
		C2H2 Zn finger	412..432	CDD:275368	5/19 (26%)
		C2H2 Zn finger	440..460	CDD:275368	8/19 (42%)
		C2H2 Zn finger	468..488	CDD:275368	7/20 (35%)
		C2H2 Zn finger	496..516	CDD:275368	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	6/51 (12%)
		C2H2 Zn finger	552..572	CDD:275368	7/19 (37%)
		C2H2 Zn finger	580..600	CDD:275368	5/20 (25%)
		C2H2 Zn finger	608..628	CDD:275368	5/19 (26%)
		zf-H2C2_2	620..643	CDD:372612	11/22 (50%)
		C2H2 Zn finger	636..656	CDD:275368	6/19 (32%)
		zf-H2C2_2	648..673	CDD:372612	12/24 (50%)
		C2H2 Zn finger	664..684	CDD:275368	7/19 (37%)
		zf-H2C2_5	690..714	CDD:372805	7/23 (30%)
		C2H2 Zn finger	692..712	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833380
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45252
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.040