DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18476 and Zfp35

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_035885.2	Gene:	Zfp35 / 22694	MGIID:	99179	Length:	580	Species:	Mus musculus

Alignment Length:	582	Identity:	163/582 - (28%)
Similarity:	256/582 - (43%)	Gaps:	113/582 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 SITNQSGYEMDLDSSETDSDLDGDHDDQHKRRKK----------SRKATYSCELCQQKFPRKYQL 414
            ::|.:||      |.|.|.    .||.:.|..::          .|:..|:|:.|.|.|.....|
Mouse    39 TVTEESG------SLEEDV----PHDSRGKEFREFGEELNDQMLFRRRQYNCDECDQSFAWSTGL 93

  Fly   415 YDHQRQSHSWSDAPHVCGRCDGRF-VSLQLLRHHNESQCRNAQKRFLCHKCPLRFRWKHNLKTHF 478
            ..||| :| |.  |:.|..|...| :|..|:.|   .:....:|.:.|..|...|....:|..|.
Mouse    94 IRHQR-TH-WK--PYECEECGKAFRMSSALVLH---QRIHTGEKPYPCSWCIKSFSRSSDLIKHQ 151

  Fly   479 REHRITNQTFECSECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRHGLK 543
            |.| ...:.::|.||.:.|.:...|.:| ..:|..| |...|..||:.|.:|..:||||:.|
Mouse   152 RVH-TGEKPYKCDECGKAFSQSSDLMIH-QRIHTGE-KPYQCSHCSKSFSQHSGMVKHLRIH--- 210

  Fly   544 EHDIPLAETLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSIT 608
                             .|.|...|..|..||.:..||..|.::         .:.:.|:...:.
Mouse   211 -----------------TGEKPYMCNHCYKHFSQSSDLIKHQRI---------HTGEKPYKCDVC 249

  Fly   609 NESGFELQLEDSETEDEM---QPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDD 670
            .::       .|::.|.:   :...|.:| |.|..|:....:..::|:|:| :|..:| |::|.:
Mouse   250 GKA-------FSQSSDRILHQRIHTGEKP-YPCAQCNKSFSQNSDLIKHRR-IHTGEK-PYKCSE 304

  Fly   671 CIFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQG 735
            |.......|::..|:  :..:.||.:.|.:|:..|....:|..|..:.         ||::.
Mouse   305 CGKAFNQSSVLILHQ--RIHTGEKPYPCNQCTKSFSRLSDLINHQRIH---------TGEKP--- 355

  Fly   736 TGDLEKDATEDGIPLLQCPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSA 800
                           ..|..|.:.:..:|.|..|.| :| .|:       |.:.|..||.....:
Mouse   356 ---------------YPCSQCSKMFSRRSDLVKHYR-IH-TGE-------KPYECDKCGKTFSQS 396

  Fly   801 AALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLT 865
            :.|:.|.|.||||||:.|:.|..:|.|.|:|..|:|:||||||:.|.:|.|.|::|..|.:|...
Mouse   397 SNLILHQRIHTGEKPYPCNSCSKSFSRGSDLIKHQRVHTGEKPYTCNLCSKSFSQSSDLTKHQRV 461

  Fly   866 HSGLKPHKCTYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHRLMRRHFDE 927
            |||.||:.|:.|.|::||:.||.||.:.||||.|:.|..|...|.|.|.|.||:  |.|..|
Mouse   462 HSGEKPYHCSSCNKAFRQSSDLILHHRVHTGERPYACTQCPRSFSQKSDLIKHQ--RIHTGE 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	401..422	CDD:275368	8/20 (40%)
		C2H2 Zn finger	431..447	CDD:275368	5/16 (31%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	490..511	CDD:275368	6/20 (30%)
		C2H2 Zn finger	520..540	CDD:275368	9/19 (47%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	668..690	CDD:275368	4/21 (19%)
		C2H2 Zn finger	698..715	CDD:275368	4/16 (25%)
		C2H2 Zn finger	753..774	CDD:275368	6/20 (30%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		zf-H2C2_2	802..825	CDD:290200	11/22 (50%)
		COG5048	814..>886	CDD:227381	33/71 (46%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	13/24 (54%)
		C2H2 Zn finger	846..866	CDD:275368	7/19 (37%)
		zf-H2C2_2	859..883	CDD:290200	10/23 (43%)
		C2H2 Zn finger	874..894	CDD:275368	9/19 (47%)
		C2H2 Zn finger	902..924	CDD:275368	9/21 (43%)
Zfp35	NP_035885.2	C2H2 Zn finger	80..100	CDD:275368	8/20 (40%)
		COG5048	102..489	CDD:227381	126/471 (27%)
		C2H2 Zn finger	106..126	CDD:275368	6/22 (27%)
		C2H2 Zn finger	134..154	CDD:275368	6/19 (32%)
		C2H2 Zn finger	162..182	CDD:275368	6/20 (30%)
		C2H2 Zn finger	190..210	CDD:275368	9/19 (47%)
		C2H2 Zn finger	218..238	CDD:275368	7/28 (25%)
		C2H2 Zn finger	246..266	CDD:275368	2/26 (8%)
		C2H2 Zn finger	274..294	CDD:275368	5/20 (25%)
		C2H2 Zn finger	302..322	CDD:275368	4/21 (19%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		C2H2 Zn finger	358..378	CDD:275368	6/20 (30%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		C2H2 Zn finger	470..490	CDD:275368	9/19 (47%)
		C2H2 Zn finger	498..518	CDD:275368	9/21 (43%)
		C2H2 Zn finger	526..545	CDD:275368
		zf-H2C2_2	541..562	CDD:404364
		C2H2 Zn finger	553..573	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100