DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and Prdm9

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_036016343.1	Gene:	Prdm9 / 213389	MGIID:	2384854	Length:	854	Species:	Mus musculus

Alignment Length:	964	Identity:	223/964 - (23%)
Similarity:	337/964 - (34%)	Gaps:	272/964 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 CLCSGCTKKLMGAYCYVKQAMAAN----------------------ELLMKHLKNGAAPTSTDCL 98
            |..||.........||.:|||...                      ...:||.|...
Mouse    70 CCFSGLRAPRPAFMCYQRQAMKPQINDSEDSDEEWTPKQQVSPPWVPFRVKHSKQQK-------- 126

  Fly    99 QEAPMELCAEQHVEVKLETED--EDCGENDVTITCSELPEPDETDMESKKSVDPLTMIETVKLEM 161
            :.:.|....|.:|:.....|:  ...|...|....|.|.|.:.:...|.|.:......:.|:::|
Mouse   127 ESSRMPFSGESNVKEGSGIENLLNTSGSEHVQKPVSSLEEGNTSGQHSGKKLSKKLRKKNVEVKM 191

  Fly   162 -EPRSVEKPAYDDPTSDFEDEDSLDNLPLYNRIQKWKTGRKSVY--KCHD-----CPRSFKRFDF 218
             ..|..:..||:: .|:.:|:|.|                   |  ||.:     ||.
Mouse   192 YRLRERKGLAYEE-VSEPQDDDYL-------------------YCEKCQNFFIDSCPN------- 229

  Fly   219 LKRHEMRVHKPETRLYDCSLCIRKFSRSE--ALEAHLKIHRNSKRSANISEHKKAKAVDLNL-CK 280
                    |.|...:.| |:..|......  :|...|:|..:....|.:....:|..:.:.| ..
Mouse   230 --------HGPPLFVKD-SMVDRGHPNHSVLSLPPGLRISPSGIPEAGLGVWNEASDLPVGLHFG 285

  Fly   281 PHGYKLIEC-MICQSQYNKIADLRRHLEEHPDIVSLCGRPNMEPHELAELFYPDSKDLSEE---Q 341
            |:..::.|. ....|.|:.:....|:..|                      |.|.:|.|:.   :
Mouse   286 PYEGQITEDEEAANSGYSWLITKGRNCYE----------------------YVDGQDESQANWMR 328

  Fly   342 LINLIRKD----LAAGIYQR--FYSITN--QSGYEMDLDSSETDSDLDGDHDDQH------KRRK 392
            .:|..|.|    |.|..|.|  ||....  :.|.|:.:        ..||...|.      .:.|
Mouse   329 YVNCARDDEEQNLVAFQYHRKIFYRTCRVIRPGCELLV--------WYGDEYGQELGIKWGSKMK 385

  Fly   393 KS-------RKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCD---GRFVSLQLLRHH 447
            |.       |...:.|.||...|..:..|..|...:|.....|....|.:   |...|.||...|
Mouse   386 KGFTAGRELRTEIHPCLLCSLAFSSQKFLTQHMEWNHRTEIFPGTSARINPKPGDPCSDQLQEQH 450

  Fly   448 NESQCRNAQ-----KRFLCHKCPLRFRWKHNLKTHFR--------EHRITNQT---------FEC 490
            .:||.:|.:     ||....:..:...:...||...|        |...|.||         |..
Mouse   451 VDSQNKNDKASNEVKRKSKPRQRISTTFPSTLKEQMRSEESKRTVEELRTGQTTNTEDTVKSFIA 515

  Fly   491 SE-------CKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIP 548
            ||       |.:.|..|.::..| ...|..|...: |:.|.|.|.::.:|::|.:.|
Mouse   516 SEISSIERQCGQYFSDKSNVNEH-QKTHTGEKPYV-CRECGRGFTQNSHLIQHQRTH-------- 570

  Fly   549 LAETLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGF 613
                        .|.|...||.|...|.:..||..|
Mouse   571 ------------TGEKPYVCRECGRGFTQKSDLIKH----------------------------- 594

  Fly   614 ELQLEDSETEDEMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCVSK 678
                        .:...|.:| |:|..|.....:|.::|:|||| |..:| |:.|.:|......|
Mouse   595 ------------QRTHTGEKP-YVCRECGRGFTQKSDLIKHQRT-HTGEK-PYVCRECGRGFTQK 644

  Fly   679 SIMDHHRQGQCSSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDA 743
            |::..|:  :..:.||.:.|.:|...|     .::.:|::|.::.    ||::
Mouse   645 SVLIKHQ--RTHTGEKPYVCRECGRGF-----TQKSVLIKHQRTH----TGEK------------ 686

  Fly   744 TEDGIPLLQCPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMR 808
                 |.: |..|.|.:..||.|..|.| .| .|:       |.::|..||....:.:.|:.|.|
Mouse   687 -----PYV-CRECGRGFTAKSVLIQHQR-TH-TGE-------KPYVCRECGRGFTAKSNLIQHQR 736

  Fly   809 RHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHK 873
            .||||||:.|..|...|...|.|..|:|.||||||:.|..||:.|.....|.:|..||:|.||:.
Mouse   737 THTGEKPYVCRECGRGFTAKSVLIQHQRTHTGEKPYVCRECGRGFTAKSVLIQHQRTHTGEKPYV 801

  Fly   874 CTYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHRLMRRHFDE 927
            |..|.:.:.|..:|..|.:.||||.|:||..||..|.|.|.|.:|:  |.|..|
Mouse   802 CRECGRGFTQKSNLIKHQRTHTGEKPYVCRECGWGFTQKSDLIQHQ--RTHTRE 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	8/49 (16%)
		C2H2 Zn finger	206..227	CDD:275368	3/25 (12%)
		C2H2 Zn finger	236..256	CDD:275368	4/21 (19%)
		C2H2 Zn finger	401..422	CDD:275368	6/20 (30%)
		C2H2 Zn finger	431..447	CDD:275368	5/18 (28%)
		C2H2 Zn finger	461..481	CDD:275368	3/27 (11%)
		C2H2 Zn finger	490..511	CDD:275368	6/27 (22%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..659	CDD:275368	8/20 (40%)
		C2H2 Zn finger	668..690	CDD:275368	5/21 (24%)
		C2H2 Zn finger	698..715	CDD:275368	3/16 (19%)
		C2H2 Zn finger	753..774	CDD:275368	8/20 (40%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		zf-H2C2_2	802..825	CDD:290200	11/22 (50%)
		COG5048	814..>886	CDD:227381	29/71 (41%)
		C2H2 Zn finger	818..838	CDD:275368	7/19 (37%)
		zf-H2C2_2	830..855	CDD:290200	13/24 (54%)
		C2H2 Zn finger	846..866	CDD:275368	6/19 (32%)
		zf-H2C2_2	859..883	CDD:290200	9/23 (39%)
		C2H2 Zn finger	874..894	CDD:275368	5/19 (26%)
		C2H2 Zn finger	902..924	CDD:275368	9/21 (43%)
Prdm9	XP_036016343.1	SSXRD	186..212	CDD:401460	7/26 (27%)
		PR-SET_PRDM7_9	251..379	CDD:380970	30/157 (19%)
		C2H2 Zn finger	523..542	CDD:275368	4/19 (21%)
		COG5048	546..>851	CDD:227381	112/409 (27%)
		C2H2 Zn finger	550..570	CDD:275368	6/19 (32%)
		C2H2 Zn finger	578..598	CDD:275368	7/60 (12%)
		C2H2 Zn finger	606..626	CDD:275368	8/20 (40%)
		C2H2 Zn finger	634..654	CDD:275368	5/21 (24%)
		C2H2 Zn finger	662..682	CDD:275368	5/24 (21%)
		C2H2 Zn finger	690..710	CDD:275368	8/20 (40%)
		C2H2 Zn finger	718..738	CDD:275368	6/19 (32%)
		C2H2 Zn finger	746..766	CDD:275368	7/19 (37%)
		C2H2 Zn finger	774..794	CDD:275368	6/19 (32%)
		C2H2 Zn finger	802..822	CDD:275368	5/19 (26%)
		C2H2 Zn finger	830..850	CDD:275368	9/21 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000