DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18476 and znf-782

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_500033.1	Gene:	znf-782 / 190310	WormBaseID:	WBGene00021931	Length:	662	Species:	Caenorhabditis elegans

Alignment Length:	388	Identity:	99/388 - (25%)
Similarity:	158/388 - (40%)	Gaps:	59/388 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   586 QLELKLSLSLHQSYDSPHNYSITNES-----GFELQLEDSETEDEMQPGVGSRPVYICELCSVQC 645
            :||...|.|...|..|||..|.:|.|     ..::|.....:.....|.......:||.:|. :.
Worm    49 ELENSDSASSLVSAGSPHGSSSSNGSHGSSPPLQVQSPSQGSGSSGSPTGQPEKRHICTVCG-KG 112

  Fly   646 KRKFEMIQHQRTMHRFDKMPHECDDCIFKCVSKSIMDHHRQGQCSSTEKKHACGKCSYKFMWPEN 710
            ...|.:::..:..|..:| |:.|..|......|:.:..|.  :..:.|:.:.|..|...|
Worm   113 FSYFSILESHKRSHTGEK-PYNCHFCQKTFAQKATLQVHE--RTHTGERPYKCRYCEKTF----- 169

  Fly   711 LEQHILLQHSKSS---VSN---PTGDRHTQGTGDLEKDATEDGIPLLQCPHCDRTYQMKSRLNNH 769
            .:......|.||:   :.|   |..|:.......|.......|....:|..|.:|:.:|:.|..|
Worm   170 AQYGTKTVHEKSAHLGIRNYKCPKCDKLLSSPSALYTHKKTHGDKTFRCDFCPKTFALKNYLKLH 234

  Fly   770 IRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASH 834
            ::.||...:||.       :|..|......|.:|..|:|.||||:|:.|..|..||.....|.||
Worm   235 VKQVHEQNERKH-------VCVYCNKGFAYAGSLQVHVRTHTGERPYVCKFCPKAFASQGNLQSH 292

  Fly   835 RRMHTGEKPFHCTVCGKDFARSDKLKRHMLTH-------------SGLKP-------------HK 873
            .|.||||:|:.|..|.:.|.:..:|..|..||             :.:.|             ::
Worm   293 ERTHTGERPYSCQFCQRTFIQKSQLTAHESTHLTQKHSVNPDSTTADILPVAGSVTDHQMVGNYE 357

  Fly   874 CTYCEKSYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHRLMRRHFDEVEAWLRRQK 936
            ||:|.|.|..|..|.:|:::||.:..:.|..||:.:.|..:|..|:      |:.||:..|.|
Worm   358 CTFCNKKYPYASSLYIHMRKHTEKSAYSCDGCGKPYSQKISLNIHQ------DQCEAFKNRLK 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	401..422	CDD:275368
		C2H2 Zn finger	431..447	CDD:275368
		C2H2 Zn finger	461..481	CDD:275368
		C2H2 Zn finger	490..511	CDD:275368
		C2H2 Zn finger	520..540	CDD:275368
		C2H2 Zn finger	638..659	CDD:275368	3/20 (15%)
		C2H2 Zn finger	668..690	CDD:275368	4/21 (19%)
		C2H2 Zn finger	698..715	CDD:275368	3/16 (19%)
		C2H2 Zn finger	753..774	CDD:275368	6/20 (30%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		zf-H2C2_2	802..825	CDD:290200	10/22 (45%)
		COG5048	814..>886	CDD:227381	28/97 (29%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	12/24 (50%)
		C2H2 Zn finger	846..866	CDD:275368	5/19 (26%)
		zf-H2C2_2	859..883	CDD:290200	10/49 (20%)
		C2H2 Zn finger	874..894	CDD:275368	8/19 (42%)
		C2H2 Zn finger	902..924	CDD:275368	6/21 (29%)
znf-782	NP_500033.1	C2H2 Zn finger	106..126	CDD:275368	3/20 (15%)
		zf-H2C2_2	119..143	CDD:290200	5/24 (21%)
		C2H2 Zn finger	134..154	CDD:275368	4/21 (19%)
		zf-H2C2_2	147..171	CDD:290200	5/30 (17%)
		C2H2 Zn finger	162..180	CDD:275368	4/22 (18%)
		COG5048	<187..404	CDD:227381	63/229 (28%)
		C2H2 Zn finger	191..211	CDD:275370	3/19 (16%)
		C2H2 Zn finger	218..239	CDD:275368	6/20 (30%)
		C2H2 Zn finger	248..268	CDD:275368	6/19 (32%)
		zf-H2C2_2	260..285	CDD:290200	12/24 (50%)
		C2H2 Zn finger	276..296	CDD:275368	8/19 (42%)
		zf-H2C2_2	288..313	CDD:290200	12/24 (50%)
		C2H2 Zn finger	304..324	CDD:275368	5/19 (26%)
		C2H2 Zn finger	386..403	CDD:275368	5/16 (31%)
		C2H2 Zn finger	424..441	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910