DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18476 and egl-43

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001022288.1	Gene:	egl-43 / 174552	WormBaseID:	WBGene00001207	Length:	543	Species:	Caenorhabditis elegans

Alignment Length:	679	Identity:	120/679 - (17%)
Similarity:	194/679 - (28%)	Gaps:	277/679 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 DCSLCIRKFSRSEALEAHLKIHRNSKRSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKI 299
            |.::|:|:..|...|:        :.:..||.|....:.:....|.......:|.:|....
Worm    63 DANICMRQEDRKTFLQ--------TSKIINIGERLLLQRLSEEECDEEDQDDLENLILLKD---- 115

  Fly   300 ADLRRHLEEHPDIVSLCGRPNMEPHELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQ 364
                   |:.||....|.:
Worm   116 -------EDRPDSTQSCTK---------------------------------------------- 127

  Fly   365 SGYEMDLDSSETDSDLDG--DHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDA 427
                    ||..||:|:|  ::..:|.            ||...:.|               .|.
Worm   128 --------SSSEDSNLNGFEEYIREHG------------ELVPGQTP---------------PDG 157

  Fly   428 PHVCGRCDGRFVSLQLLRHHNESQCRNAQKRFLCHKCPLRFRWKHNLKTHFREHRITNQTFECSE 492
            .|.||.|...|.|...|:.|:...|  :.|.|.||.||..:....||..|.|.|   :..:.|..
Worm   158 SHKCGVCPKSFSSASGLKQHSHIHC--SLKPFRCHLCPKSYTQFSNLCRHRRVH---SDGWTCPT 217

  Fly   493 CKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAAT 557
            |:.....:.:||.|
Worm   218 CQSQMPSQAALTKH--------------------------------------------------- 231

  Fly   558 SRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSET 622
             ||      .|.|..|:                          .|....:...||
Worm   232 -RP------VCEMTALY--------------------------KPLMAQLAGLSG---------- 253

  Fly   623 EDEMQPGVGSRPV--YICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCVSKSIMDHHR 685
                ..|:||.|.  :|.::.:                    :.||  ....|...:.......:
Worm   254 ----AGGLGSVPYWPHILQMAT--------------------QAPH--FPLAFLAANPEAYKLMQ 292

  Fly   686 QGQCSSTEKKHACGKCSYKFMWPENLEQHILLQHSK---------SSVSNPTGDRHTQG-TGDLE 740
            |..|:|.:.:.:.|..|...  |...|...|....|         :|.|:...||.:.| :|:.:
Worm   293 QTTCASPDAECSSGHASESS--PTTTEPVDLTATPKPPSTSEMETTSKSDDGEDRDSIGDSGNDD 355

  Fly   741 KDATEDGIPLLQCPHCDRTYQMKSRLNNH-IRDVHINGDRKRKEAIK------------------ 786
            .|.:|.|:    ......|...|.|..:| |.|: :...:...:|:.
Worm   356 DDDSEAGV----LDESSTTTSTKKRPTSHTISDI-LAAPQLGAQALNSTFLGMLQRSLNYNPAVP 415

  Fly   787 ---RFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTV 848
               .||.::.|.:..|:.:    ....:|:..:.|..|:..|||.:.|..|.|.||||:|:.|..
Worm   416 SPHSFLRAMSGAKASSSPS----SSSGSGKDRYTCKFCQKVFPRSANLTRHLRTHTGEQPYKCQY 476

  Fly   849 CGKDFARSDKLKRHMLT-----HSGLKPH 872
            |.:.|:.|..|:||:..     ::.|.||
Worm   477 CERSFSISSNLQRHVRNIHNKPNTSLTPH 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368	4/19 (21%)
		C2H2 Zn finger	401..422	CDD:275368	3/20 (15%)
		C2H2 Zn finger	431..447	CDD:275368	6/15 (40%)
		C2H2 Zn finger	461..481	CDD:275368	8/19 (42%)
		C2H2 Zn finger	490..511	CDD:275368	5/20 (25%)
		C2H2 Zn finger	520..540	CDD:275368	0/19 (0%)
		C2H2 Zn finger	638..659	CDD:275368	0/20 (0%)
		C2H2 Zn finger	668..690	CDD:275368	2/21 (10%)
		C2H2 Zn finger	698..715	CDD:275368	4/16 (25%)
		C2H2 Zn finger	753..774	CDD:275368	6/21 (29%)
		C2H2 Zn finger	790..810	CDD:275368	2/19 (11%)
		zf-H2C2_2	802..825	CDD:290200	3/22 (14%)
		COG5048	814..>886	CDD:227381	23/64 (36%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	11/24 (46%)
		C2H2 Zn finger	846..866	CDD:275368	7/24 (29%)
		zf-H2C2_2	859..883	CDD:290200	6/19 (32%)
		C2H2 Zn finger	874..894	CDD:275368
		C2H2 Zn finger	902..924	CDD:275368
egl-43	NP_001022288.1	SFP1	<115..210	CDD:227516	35/191 (18%)
		C2H2 Zn finger	161..181	CDD:275368	7/19 (37%)
		C2H2 Zn finger	189..209	CDD:275368	8/19 (42%)
		C2H2 Zn finger	215..232	CDD:275368	5/68 (7%)
		zf-C2H2	444..466	CDD:395048	8/21 (38%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		zf-H2C2_2	458..482	CDD:404364	10/23 (43%)
		C2H2 Zn finger	474..495	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000