DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and ZNF721

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_597731.2	Gene:	ZNF721 / 170960	HGNCID:	29425	Length:	923	Species:	Homo sapiens

Alignment Length:	950	Identity:	225/950 - (23%)
Similarity:	338/950 - (35%)	Gaps:	284/950 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 STDTDNLLKLATPSKKYPDKLLSEILCELTEINLDA---TGSQKFPQCLCSGCTKKLMGAYCYVK 73
            ||:.:...|:.|..|.|..|...:.....:.:|...   ||.:.:.   |..|.|.:..:..:.|
Human   205 STNLNEYKKIHTGDKPYKCKECGKAFMHSSHLNKHEKIHTGEKPYK---CKECGKVISSSSSFAK 266

  Fly    74 -----------------QAMAANELLMKH--LKNGAAPTSTDCLQEAPMELCAEQHVEVKLETED 119
                             :|...:..|.||  :..|..|.:.:...:| ....|..:|..::.|.:
Human   267 HKRIHTGEKPFKCLECGKAFNISTTLTKHRRIHTGEKPYTCEVCGKA-FRQSANLYVHRRIHTGE 330

  Fly   120 E--DCGENDVTITCSELPEPDETDMESKKSVDPLTMIETVKLEMEPRSVEKPAYDDPTSDFEDED 182
            :  .|||...|...|.
Human   331 KPYTCGECGKTFRQSA------------------------------------------------- 346

  Fly   183 SLDNLPLYNRIQKWKTGRKSVYKCHDCPRSFKRFDFLKRHEMRVHKPETRLYDCSLCIRKFSRSE 247
               ||.::.||.   ||.|. |||.||.::|.|:..|.:|: ::|..| :.|.|..|.:.|:.|.
Human   347 ---NLYVHRRIH---TGEKP-YKCEDCGKAFGRYTALNQHK-KIHTGE-KPYKCEECGKAFNSST 402

  Fly   248 ALEAHLKIHRNSK------------RSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIA 300
            .|.||.:||...|            .|.|::|:||....|    ||:     :|..|...:....
Human   403 NLTAHKRIHTREKPYTCEDRGRAFGLSTNLNEYKKIHTGD----KPY-----KCKECGKAFIHSL 458

  Fly   301 DLRRHLEEH----PDIVSLCGRPNMEPHELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSI 361
            .|.:|.:.|    |.....||:                                         .|
Human   459 HLNKHEKIHTGKKPYKCKQCGK-----------------------------------------VI 482

  Fly   362 TNQSGYEMDLDSSETDSDLDGDHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSD 426
            |:.|.:.                  :|||.....| .:.|..|.:.|.....|..| |:.|: .:
Human   483 TSSSSFA------------------KHKRIHTGEK-PFECLECGKAFTSSTTLTKH-RRIHT-GE 526

  Fly   427 APHVCGRCDGRFVSLQLLRHHNESQCRNAQKRFLCHKCPLRFRWKHNLKTHFREHRITNQTFECS 491
            .|:.|..|...|....:|..|.  :....:|.:.|.:|...||...||..|.|.| ...:.::|.
Human   527 KPYTCEVCGKAFRQSAILYVHR--RIHTGEKPYTCEECGKTFRQSANLYVHRRIH-TGEKPYKCE 588

  Fly   492 ECKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAA 556
            ||.:.|.:...|..| ..:|..| ||..|:.|.:.|..:..|.:..|.:
Human   589 ECGKAFGRYTDLNQH-KKIHTGE-KLYKCEECGKDFVWYTDLNQQKKIY---------------- 635

  Fly   557 TSRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSE 621
                .|.|...|..|...|....||..|.::                   :|.|..
Human   636 ----TGEKPYKCEECGKAFAPSTDLNQHTKI-------------------LTGEQS--------- 668

  Fly   622 TEDEMQPGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCVSKS--IMDHH 684
                          |.||.|.........:.||:: :|..:| |::|::| .|..|:|  :..|.
Human   669 --------------YKCEECGKAFGWSIALNQHKK-IHTGEK-PYKCEEC-GKAFSRSRNLTTHR 716

  Fly   685 RQGQCSSTEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIP 749
            |   ..:.||.:.|......|.|..||.::..:.         |||:
Human   717 R---VHTREKPYKCEDRGRSFGWSTNLNEYKKIH---------TGDK------------------ 751

  Fly   750 LLQCPHCDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEK 814
            |.:|..|.:.::..|.||.| ..:|...        |.:.|..||....|:::...|.|.|||||
Human   752 LYKCKECGKVFKQSSHLNRH-EKIHTGK--------KPYKCKECGKVITSSSSFAKHKRIHTGEK 807

  Fly   815 PFKCDLCEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEK 879
            ||||..|..||...:.|..|||:||||||:.|..|||.|.:|..|..|...|:|.||:.|..|.|
Human   808 PFKCLECGKAFTSSTTLTKHRRIHTGEKPYTCEECGKAFRQSAILYVHRRIHTGEKPYTCGECGK 872

  Fly   880 SYRQAKDLKLHLQQHTGECPFVCGTCGERFIQSSTLEKHR 919
            ::||:.:|..|.:.||||.|:.||.||:.|.||:.|..|:
Human   873 TFRQSANLYAHKKIHTGEKPYTCGDCGKTFRQSANLYAHK 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	16/91 (18%)
		C2H2 Zn finger	206..227	CDD:275368	7/20 (35%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		C2H2 Zn finger	401..422	CDD:275368	6/20 (30%)
		C2H2 Zn finger	431..447	CDD:275368	4/15 (27%)
		C2H2 Zn finger	461..481	CDD:275368	8/19 (42%)
		C2H2 Zn finger	490..511	CDD:275368	6/20 (30%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	668..690	CDD:275368	7/23 (30%)
		C2H2 Zn finger	698..715	CDD:275368	5/16 (31%)
		C2H2 Zn finger	753..774	CDD:275368	6/20 (30%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		zf-H2C2_2	802..825	CDD:290200	12/22 (55%)
		COG5048	814..>886	CDD:227381	35/71 (49%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	15/24 (63%)
		C2H2 Zn finger	846..866	CDD:275368	8/19 (42%)
		zf-H2C2_2	859..883	CDD:290200	9/23 (39%)
		C2H2 Zn finger	874..894	CDD:275368	7/19 (37%)
		C2H2 Zn finger	902..924	CDD:275368	9/17 (53%)
ZNF721	NP_597731.2	C2H2 Zn finger	83..103	CDD:275368
		COG5048	93..492	CDD:227381	77/416 (19%)
		C2H2 Zn finger	111..131	CDD:275368
		C2H2 Zn finger	139..159	CDD:275368
		zf-H2C2_2	151..176	CDD:290200
		C2H2 Zn finger	167..187	CDD:275368
		C2H2 Zn finger	223..243	CDD:275368	2/19 (11%)
		zf-H2C2_2	235..257	CDD:290200	5/24 (21%)
		C2H2 Zn finger	251..271	CDD:275368	4/19 (21%)
		C2H2 Zn finger	279..299	CDD:275368	4/19 (21%)
		zf-H2C2_2	292..316	CDD:290200	6/24 (25%)
		C2H2 Zn finger	307..327	CDD:275368	3/20 (15%)
		zf-H2C2_2	319..344	CDD:290200	6/24 (25%)
		C2H2 Zn finger	335..355	CDD:275368	8/71 (11%)
		zf-H2C2_2	347..372	CDD:290200	13/28 (46%)
		C2H2 Zn finger	363..383	CDD:275368	7/20 (35%)
		zf-H2C2_2	375..400	CDD:290200	8/26 (31%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		COG5048	442..885	CDD:227381	148/622 (24%)
		C2H2 Zn finger	447..467	CDD:275368	4/19 (21%)
		C2H2 Zn finger	475..495	CDD:275368	8/78 (10%)
		zf-H2C2_2	487..512	CDD:290200	7/43 (16%)
		C2H2 Zn finger	503..523	CDD:275368	6/20 (30%)
		zf-H2C2_2	516..540	CDD:290200	8/25 (32%)
		C2H2 Zn finger	531..551	CDD:275368	5/21 (24%)
		zf-H2C2_2	544..568	CDD:290200	6/25 (24%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		zf-H2C2_2	571..596	CDD:290200	9/25 (36%)
		C2H2 Zn finger	587..607	CDD:275368	6/20 (30%)
		C2H2 Zn finger	615..634	CDD:275368	4/18 (22%)
		C2H2 Zn finger	643..663	CDD:275368	6/38 (16%)
		C2H2 Zn finger	671..691	CDD:275368	5/20 (25%)
		zf-H2C2_2	683..708	CDD:290200	8/27 (30%)
		C2H2 Zn finger	699..719	CDD:275368	7/23 (30%)
		C2H2 Zn finger	755..775	CDD:275368	6/20 (30%)
		zf-H2C2_2	767..789	CDD:290200	8/30 (27%)
		C2H2 Zn finger	783..803	CDD:275368	6/19 (32%)
		zf-H2C2_2	795..820	CDD:290200	14/24 (58%)
		C2H2 Zn finger	811..831	CDD:275368	8/19 (42%)
		zf-H2C2_2	824..848	CDD:290200	15/23 (65%)
		C2H2 Zn finger	839..859	CDD:275368	8/19 (42%)
		zf-H2C2_2	852..876	CDD:290200	9/23 (39%)
		C2H2 Zn finger	867..887	CDD:275368	7/19 (37%)
		C2H2 Zn finger	895..915	CDD:275368	9/17 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143219
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940