DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and LOC102556967

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_008757653.1	Gene:	LOC102556967 / 102556967	RGDID:	7510716	Length:	727	Species:	Rattus norvegicus

Alignment Length:	813	Identity:	193/813 - (23%)
Similarity:	296/813 - (36%)	Gaps:	237/813 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 AYDDPTSDFEDED--SLDN----------LPLYNRIQKWKTGRKSVYKCHDCPRSFKRFDFLKRH 222
            ::||.|.||..|:  .||:          |.:|:.:  ...|:..:...|.  :.|.:..||...
  Rat    50 SFDDVTVDFSQEEWQHLDSAQRCLYQEVMLEIYSHL--LAVGKLQLDIQHQ--QIFVKASFLTDA 110

  Fly   223 EMRVHKPETRLYDCSLCIRKFSRSEALEAHLKIHRNSKRSANISEHKKAKAVDLNLCKPHGYKLI 287
            ...|    ||...|...:.|..:.:...|        ||..
  Rat   111 TNEV----TRHGSCCSVLEKLWQDDDTAA--------KRDQ------------------------ 139

  Fly   288 ECMICQSQYNKIADLRRHLEEHPDIVSLCG-RPNMEPHELAELFYP-----DSKDLSEEQLINLI 346
                 |||...|:......::..:|.|:|. ....|||.::..:.|     |::..:.|||.::|
  Rat   140 -----QSQVRPISPDAFRNQKLLNIDSVCDYEETGEPHLISTQYVPPRANSDNQSNTIEQLNDII 199

  Fly   347 RKDLAAGIYQRFYSITNQSGYEMDL-------DSSETDSDLDG---------DHDDQHKRR---- 391
                  |.:|.|     ..|...|:       :.|..:|....         ||:...:.:
  Rat   200 ------GSHQCF-----TQGSSNDICTVPPQREKSYNESQFGNILSPNLPLMDHEINFQDKPVGY 253

  Fly   392 ------------------KKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRC---- 434
                              ..:.:.::.|..|.:.|..|.:|..|. ::|. .:.|:.|..|
  Rat   254 TGCGKVFTGEVVFCEQQITNNMETSFICHTCGKTFLHKSKLASHS-ETHR-EETPYECPDCAKSR 316

  Fly   435 DGRFVSLQLLRHHNESQC--RNAQKRFLCHKCPLRFRWKHNLKTHFREHRITNQTFECSECKRVF 497
            .|: .|||:|       |  :..:|.:.||.|...|.:..:||.|.|.| ...:.:.||:|.:.|
  Rat   317 RGK-SSLQVL-------CGIQTKEKPYECHVCGKSFSYTSHLKVHLRTH-TGEKPYACSDCGKAF 372

  Fly   498 DKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAATSRPNG 562
            .:|..||:| ..:|..| |...|..|.:.|.....|.||.:.|                    .|
  Rat   373 SQKSVLTIH-QRIHTGE-KPYTCSDCGKMFVCASDLTKHCRFH--------------------TG 415

  Fly   563 AKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSETEDEMQ 627
            .|...|..|...|....:|.||.:        :|.| :.|
  Rat   416 EKPYECPDCGKSFSIKSNLLAHHR--------IHTS-EGP------------------------- 446

  Fly   628 PGVGSRPVYICELCSVQCKRKFEMIQHQRTMHRF--DKMPHECDDCIFKCVSKSIMDHHRQGQCS 690
                    |.|    ..|...|..|...:..|:.  |.....|.||......||::..|:  :..
  Rat   447 --------YKC----FDCGESFRKISQLKVHHQIHTDGRSFVCSDCGMAFSQKSVLTTHQ--RIH 497

  Fly   691 STEKKHACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPH 755
            |.:|.:.|..|...|::..:|::|....         ||::.                  .:|..
  Rat   498 SGDKCYPCNDCGKLFLYASDLKKHCRFH---------TGEKP------------------YKCHD 535

  Fly   756 CDRTYQMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDL 820
            |.::|.:||.|:.|.| :| .|:|..|       |..||...|..:.|..|.:.||||||:||..
  Rat   536 CGKSYSVKSHLHVHHR-IH-TGERPYK-------CDDCGKSFRRNSHLQMHQQTHTGEKPYKCSD 591

  Fly   821 CEMAFPRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAK 885
            |..:|.|.|.|..|.|:||||||:.|:.|||.|.....|..|...|:|.||:.|:.|.|:.....
  Rat   592 CGKSFRRASHLKVHHRIHTGEKPYVCSECGKAFNDRSVLSTHQRIHTGEKPYICSDCGKAMSSKA 656

  Fly   886 DLKLHLQQHTGECPFVCGTCGERFIQSSTLEKH 918
            :||.|.:.||||.|:||..||:.|...|:..:|
  Rat   657 NLKEHQRIHTGEKPYVCAECGKAFSDKSSFYRH 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368	4/20 (20%)
		C2H2 Zn finger	236..256	CDD:275368	3/19 (16%)
		C2H2 Zn finger	401..422	CDD:275368	6/20 (30%)
		C2H2 Zn finger	431..447	CDD:275368	7/19 (37%)
		C2H2 Zn finger	461..481	CDD:275368	8/19 (42%)
		C2H2 Zn finger	490..511	CDD:275368	8/20 (40%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..659	CDD:275368	4/20 (20%)
		C2H2 Zn finger	668..690	CDD:275368	6/21 (29%)
		C2H2 Zn finger	698..715	CDD:275368	4/16 (25%)
		C2H2 Zn finger	753..774	CDD:275368	8/20 (40%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		zf-H2C2_2	802..825	CDD:290200	11/22 (50%)
		COG5048	814..>886	CDD:227381	31/71 (44%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	14/24 (58%)
		C2H2 Zn finger	846..866	CDD:275368	7/19 (37%)
		zf-H2C2_2	859..883	CDD:290200	9/23 (39%)
		C2H2 Zn finger	874..894	CDD:275368	6/19 (32%)
		C2H2 Zn finger	902..924	CDD:275368	6/17 (35%)
LOC102556967	XP_008757653.1	KRAB	48..89	CDD:396083	10/40 (25%)
		C2H2 Zn finger	254..273	CDD:275368	0/18 (0%)
		C2H2 Zn finger	281..301	CDD:275368	6/20 (30%)
		COG5048	328..702	CDD:227381	129/469 (28%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		C2H2 Zn finger	365..385	CDD:275368	8/20 (40%)
		C2H2 Zn finger	393..413	CDD:275368	6/19 (32%)
		C2H2 Zn finger	421..441	CDD:275368	6/27 (22%)
		C2H2 Zn finger	449..469	CDD:275368	5/23 (22%)
		C2H2 Zn finger	477..497	CDD:275368	6/21 (29%)
		C2H2 Zn finger	505..525	CDD:275368	5/19 (26%)
		C2H2 Zn finger	533..553	CDD:275368	8/20 (40%)
		C2H2 Zn finger	561..581	CDD:275368	6/19 (32%)
		C2H2 Zn finger	589..609	CDD:275368	8/19 (42%)
		C2H2 Zn finger	617..637	CDD:275368	7/19 (37%)
		C2H2 Zn finger	645..665	CDD:275368	6/19 (32%)
		C2H2 Zn finger	673..693	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910