DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and znf142

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_002934000.3	Gene:	znf142 / 100485110	XenbaseID:	XB-GENE-1032931	Length:	1898	Species:	Xenopus tropicalis

Alignment Length:	1062	Identity:	231/1062 - (21%)
Similarity:	383/1062 - (36%)	Gaps:	263/1062 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RTCDSTDT--DNLLKLATPSKKYPDKLLSEILCELTE-INLDATGSQKFPQCLCSGCTKKLMGAY 69
            :..|.|:.  ||.:.:...|      ||:.|..|..| .|:   |.:.||..:
Frog   858 QVADMTEASGDNNISVTDES------LLATITLEPVETCNI---GLEDFPVQI------------ 901

  Fly    70 CYVKQAMAANELLMKHLKNGAAPTSTDCLQEAPMELCAEQHVEVKLETEDEDCGEN--------- 125
                |..|:.|||.|.....|.....|.||.....||..:::.|:   :|.:||:.
Frog   902 ----QLSASTELLSKETSEEALGACEDPLQAREELLCFTENLAVE---DDINCGQEYEEEADPSL 959

  Fly   126 -----------------------DVTITCSELPEPDETDMESKKSVDPLTMIET--------VKL 159
                                   |:...|::||.....:::.:.:..||.:.|:        |:|
Frog   960 EDHDKMHESSETRAKFNQEPLLCDLNDKCTDLPVHVGANLDLQHNGIPLEVEESWAHVIKDGVQL 1024

  Fly   160 EMEPRSVE-----------KPAYDDPTSDF------------EDEDSLDNLPLYNRIQKWKT-GR 200
            .:...|.|           ..::.:.|.:.            :|:|..:.|.|..|:|.... .|
Frog  1025 TIVCESSELADNGTTEEETSASFHEDTEECSRPESMLRTLRKQDKDQAETLVLEGRVQMLVVQSR 1089

  Fly   201 KSVYKCHDCPRSFKRFDFLKRH-EMRVHKPETRLYDCSLCIRKFSRSEALEAHL-----KIHRNS 259
            ..||:|..|....::...:.:| :...|..::.|. |..|...|.:...|..|:     .|.:..
Frog  1090 TPVYRCEKCSYITRKEGCMLQHSKSGCHARKSSLV-CEECGASFKQQRGLNTHIIKKCPAILKRK 1153

  Fly   260 KRSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIADLRRHLEEHPDIVSLCGRPNMEPH 324
            |.|.......:|...:..|..|   .|.|.::.:||.:..:::|   .||...:|.|.
Frog  1154 KPSLQAVTSAEATISETGLEAP---ALDEGIMAESQASLTSEIR---VEHVHPLSPCQ------- 1205

  Fly   325 ELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQSGYEMDLDSSETDSDLDGD----HD 385
                               :||.::|...|.::...:.......::..||.:| ||..|    ..
Frog  1206 -------------------DLILEELKGNISEKNNVLDKAQNRIIEFSSSASD-DLGPDPLMTSG 1250

  Fly   386 DQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRHHNE- 449
            .|.:.:.|..:..:.|..|.....|:..:..|.|.:         |....|......|.||..|
Frog  1251 FQDREKYKFEQGKFRCLFCSFVCSRECTIICHVRDN---------CRELRGNSSETALRRHLRER 1306

  Fly   450 ------SQCRNAQK----------------RFLCHKCPLRFRWKHNLKTHFREHRITNQTFECSE 492
                  .:.:|.::                |..|..||........::||.::..:.....:|..
Frog  1307 SVSSVDEESQNTEEDEDHRKEFVYKIDGESRISCPSCPFTCSQNRAMRTHMKKGCLKPGELQCPL 1371

  Fly   493 CKRVFDKKKSLTVHLLSVHAEESKLIPCQWCSRKFYRHDYLVK-------HLK-RH-GLKEHDIP 548
            |     ..:.::...|..|.|..:...|.....|..:.|:..|       |:| || |:|.|...
Frog  1372 C-----SFRCMSSAALKRHKELHQKYSCNRAQLKCKQCDFTCKQPRCMKQHVKIRHEGVKPHRCQ 1431

  Fly   549 LAE-------TLIAATSRPNGAKRITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYS 606
            ..:       .|.|..|...|..||:|..|:..|.....||.|       ...:|:...: |..|
Frog  1432 YCDFSTTRRYRLDAHESLHTGVGRISCDSCSRTFGTNSKLRLH-------QRRVHEKKPT-HFCS 1488

  Fly   607 ITNESGFELQLEDSETEDEMQPGVGS----RPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHE 667
            :.:.||:        :::::...:||    .|.:.|::|......:..:.||....|: :|..||
Frog  1489 LCDYSGY--------SQNDIARHMGSCHNGEPAFPCDVCQASFSSEAALKQHSLRKHQ-EKATHE 1544

  Fly   668 CDDCIFKCVSKS-----IMDHHRQGQCSSTEK----------------KHACGKCSYKFMWPENL 711
            |..|.|.|.|.:     :..||.|..|:..::                .|.|..|.|.....:.|
Frog  1545 CLQCQFSCHSLATLRCHLQKHHLQLDCTICKQTFCRRQDLEEHRKSHFAHHCHLCQYAAKDRQQL 1609

  Fly   712 EQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPHCDRTYQMKSRLNNHIRDVHIN 776
            ..|...:|...:|                 ...|..:.||.||.|  ::..:.:|   :.|.|:.
Frog  1610 VHHYAEEHETPAV-----------------PGAEQEMGLLCCPFC--SFSCRHQL---VYDHHVK 1652

  Fly   777 GDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRHSELASHRRMHTGE 841
            |    ...|:.:.||.|...|::...:..|.|.||||||:||.||..|....|.|..|.|:|..|
Frog  1653 G----HGGIRVYKCSDCEYTTKNKQKITWHSRIHTGEKPYKCHLCSYACADPSRLKYHMRIHKDE 1713

  Fly   842 KPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQ-QHTGECPFVCGTC 905
            |.:.|..||......::||.||..|:||||::|..|:....:|..|::|.: :|.....|:|..|
Frog  1714 KKYLCPECGYKCKWVNQLKYHMTKHTGLKPYQCEECDYCTNRADALRVHRETRHREVRSFICEQC 1778

  Fly   906 GERFIQSSTLEKHRLMRRHFDE 927
            |:.|.....|:.|  ||:|.:|
Frog  1779 GKAFKTRFLLKTH--MRKHSEE 1798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	19/78 (24%)
		C2H2 Zn finger	206..227	CDD:275368	3/21 (14%)
		C2H2 Zn finger	236..256	CDD:275368	5/24 (21%)
		C2H2 Zn finger	401..422	CDD:275368	5/20 (25%)
		C2H2 Zn finger	431..447	CDD:275368	4/15 (27%)
		C2H2 Zn finger	461..481	CDD:275368	5/19 (26%)
		C2H2 Zn finger	490..511	CDD:275368	3/20 (15%)
		C2H2 Zn finger	520..540	CDD:275368	6/27 (22%)
		C2H2 Zn finger	638..659	CDD:275368	4/20 (20%)
		C2H2 Zn finger	668..690	CDD:275368	8/26 (31%)
		C2H2 Zn finger	698..715	CDD:275368	4/16 (25%)
		C2H2 Zn finger	753..774	CDD:275368	5/20 (25%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		zf-H2C2_2	802..825	CDD:290200	12/22 (55%)
		COG5048	814..>886	CDD:227381	29/71 (41%)
		C2H2 Zn finger	818..838	CDD:275368	8/19 (42%)
		zf-H2C2_2	830..855	CDD:290200	9/24 (38%)
		C2H2 Zn finger	846..866	CDD:275368	7/19 (37%)
		zf-H2C2_2	859..883	CDD:290200	11/23 (48%)
		C2H2 Zn finger	874..894	CDD:275368	5/20 (25%)
		C2H2 Zn finger	902..924	CDD:275368	8/21 (38%)
znf142	XP_002934000.3	C2H2 Zn finger	358..378	CDD:275368
		C2H2 Zn finger	386..406	CDD:275368
		C2H2 Zn finger	414..431	CDD:275368
		C2H2 Zn finger	448..468	CDD:275368
		C2H2 Zn finger	534..555	CDD:275368
		C2H2 Zn finger	563..584	CDD:275368
		C2H2 Zn finger	592..612	CDD:275368
		C2H2 Zn finger	620..640	CDD:275368
		C2H2 Zn finger	648..668	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	703..720	CDD:275368
		C2H2 Zn finger	1401..1422	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1430..1450	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1458..1476	CDD:275368	6/24 (25%)
		C2H2 Zn finger	1516..1537	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1545..1565	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1571..1591	CDD:275368	1/19 (5%)
		C2H2 Zn finger	1634..1654	CDD:275368	7/28 (25%)
		C2H2 Zn finger	1662..1682	CDD:275368	6/19 (32%)
		SFP1	<1684..1739	CDD:227516	23/54 (43%)
		C2H2 Zn finger	1690..1710	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1718..1738	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1746..1767	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1775..1795	CDD:275368	8/21 (38%)
		C2H2 Zn finger	1803..1823	CDD:275368
		C2H2 Zn finger	1831..1851	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910