DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18476 and Gm14124

DIOPT Version :9

Sequence 1:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001135882.1	Gene:	Gm14124 / 100216455	MGIID:	3652002	Length:	715	Species:	Mus musculus

Alignment Length:	814	Identity:	203/814 - (24%)
Similarity:	309/814 - (37%)	Gaps:	207/814 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 SKKSVDPLTMIETVKLEMEPRSVEKPAYDDPTSDFEDEDSLDNLPL---YNRIQKWKTGRKSVYK 205
            |:|::....|:||.      |::....|     .:||.::.::|.:   |.|.::..|.:: :.:
Mouse    24 SQKNLYRDVMLETY------RNLAAIGY-----VWEDHNTEEHLHISRRYERHERSHTAQQ-LSE 76

  Fly   206 CHDCPRSFKRFDFLKRHEMRVHKPETRLYDCSLCIRKFSRSEALEAHLKIHRNSKRSA------- 263
            ...|.::| .|....:.:.::|..||. |:|:.|.:.|:|...|..|.:||...|..|
Mouse    77 FIQCDKAF-AFQSHNQRKEKIHNAETP-YECNQCGKSFARKSHLLRHKRIHTGEKPYACNQCGKD 139

  Fly   264 -----NISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIADLRRHLEEHPDIVSLCGRPNMEP 323
                 .:..||:.:.         |.|..:|..|...:.....||.|...|
Mouse   140 FASPSYLQYHKRVRT---------GEKPYKCNQCGKAFACSTGLRGHKRTH-------------- 181

  Fly   324 HELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQSG--YEMDLDSSETDSDLDGDHDD 386
                          :||:|....:.|.|         ...|||  |
Mouse   182 --------------TEEKLNECNQCDKA---------FAGQSGLLY------------------- 204

  Fly   387 QHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFVSLQLLRHHNESQ 451
             |||.....| .:.|..|.:.|.|...|..|:| .|: .:.|:.|.:|:...|....|.:|..:.
Mouse   205 -HKRTHTGEK-PFQCNQCGKTFARNTHLLQHKR-VHT-GEKPYECNQCEKASVCHIGLLYHKRTH 265

  Fly   452 CRNAQKRFLCHKCPLRFRWKHNLKTHFREHRITNQTFECSECKRVFDKKKSLTVHLLSVHAEESK 516
            .  .|:.:.|::|.....:...:|...|.| ...:.|||::|.:.|.:|..|..| ..:|..| |
Mouse   266 A--GQRPYECNECGKSIVYHSCIKQCKRRH-TGEKPFECNQCGKSFARKSHLLRH-KRIHTGE-K 325

  Fly   517 LIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAATSRPNGAKRITCRMCNLHFERIVDL 581
            ...|..|.:.|.|...|..|.:.|                    .|.|...|:.|...|.....|
Mouse   326 PYKCDQCGKDFARPSSLQYHKRVH--------------------TGEKPYECKQCGKAFACSTVL 370

  Fly   582 RAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSETEDEMQPGVGSRPVYICELCSVQCK 646
            |.|.:..                   |.|..||                       |..|.....
Mouse   371 RRHKRAH-------------------TGEKPFE-----------------------CYQCGKSFA 393

  Fly   647 RKFEMIQHQRTMHRFDKMPHECDDCIFKCVSKSIMDHHRQGQCS---STEKKHACGKCSYKFMWP 708
            .|..:::|:| :|..:| |::||.|     .|..:.|....||.   :.||...|.:|...|
Mouse   394 SKSHLLRHKR-IHTGEK-PYKCDQC-----GKDFVYHSCIKQCKRRHAGEKPFECNQCGKSF--- 448

  Fly   709 ENLEQHILLQHSKSSVSNPTGDRHTQ---------GTGDLEK-DATEDGIPLLQCPHCDRTYQMK 763
              ..:..||:|.:..    ||::|.:         .|..|:. .....|....:|..|.:.:...
Mouse   449 --ASKSYLLRHKRIH----TGEKHYKCDQCGKDFASTYSLQNHKRVHTGEKPYECKQCGKAFACS 507

  Fly   764 SRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAFPRH 828
            |:|.:|.| .| .|:       |.|.|:.||......:.|:.|.|.||||||:|||.|...|.|.
Mouse   508 SKLRSHKR-TH-TGE-------KPFECNQCGKSFAIKSHLLRHKRIHTGEKPYKCDQCGKDFARP 563

  Fly   829 SELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGLKPHKCTYCEKSYRQAKDLKLHLQQ 893
            |.|..|:|:||||||:.|..|||.||.|.:|:.|..||:|.||::|..|.|::........|.:.
Mouse   564 SSLQYHKRVHTGEKPYECKQCGKAFACSRRLRIHKRTHTGEKPYECNQCGKAFSSPSGFLYHKRT 628

  Fly   894 HTGECPFVCGTCGERFIQSSTLEKHRLMRRHFDE 927
            ||||.|:.|..||:.||..|..:.|:  |.|..|
Mouse   629 HTGERPYECNECGKSFIHRSNFQMHK--RTHTGE 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071
		C2H2 Zn finger	206..227	CDD:275368	3/20 (15%)
		C2H2 Zn finger	236..256	CDD:275368	6/19 (32%)
		C2H2 Zn finger	401..422	CDD:275368	7/20 (35%)
		C2H2 Zn finger	431..447	CDD:275368	4/15 (27%)
		C2H2 Zn finger	461..481	CDD:275368	4/19 (21%)
		C2H2 Zn finger	490..511	CDD:275368	6/20 (30%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	668..690	CDD:275368	6/21 (29%)
		C2H2 Zn finger	698..715	CDD:275368	3/16 (19%)
		C2H2 Zn finger	753..774	CDD:275368	6/20 (30%)
		C2H2 Zn finger	790..810	CDD:275368	6/19 (32%)
		zf-H2C2_2	802..825	CDD:290200	13/22 (59%)
		COG5048	814..>886	CDD:227381	35/71 (49%)
		C2H2 Zn finger	818..838	CDD:275368	9/19 (47%)
		zf-H2C2_2	830..855	CDD:290200	14/24 (58%)
		C2H2 Zn finger	846..866	CDD:275368	9/19 (47%)
		zf-H2C2_2	859..883	CDD:290200	10/23 (43%)
		C2H2 Zn finger	874..894	CDD:275368	4/19 (21%)
		C2H2 Zn finger	902..924	CDD:275368	8/21 (38%)
Gm14124	NP_001135882.1	KRAB	4..>45	CDD:214630	6/26 (23%)
		KRAB	4..43	CDD:279668	6/24 (25%)
		C2H2 Zn finger	79..97	CDD:275368	3/18 (17%)
		COG5048	87..514	CDD:227381	120/579 (21%)
		C2H2 Zn finger	105..125	CDD:275368	6/19 (32%)
		zf-H2C2_2	117..142	CDD:290200	6/24 (25%)
		C2H2 Zn finger	133..153	CDD:275368	2/19 (11%)
		C2H2 Zn finger	161..181	CDD:275368	5/19 (26%)
		C2H2 Zn finger	189..209	CDD:275368	9/48 (19%)
		zf-H2C2_2	202..226	CDD:290200	8/44 (18%)
		C2H2 Zn finger	217..237	CDD:275368	7/20 (35%)
		C2H2 Zn finger	245..265	CDD:275368	5/19 (26%)
		C2H2 Zn finger	273..293	CDD:275368	4/19 (21%)
		C2H2 Zn finger	301..321	CDD:275368	6/20 (30%)
		zf-H2C2_2	313..338	CDD:290200	8/26 (31%)
		C2H2 Zn finger	329..349	CDD:275368	6/19 (32%)
		zf-H2C2_2	341..366	CDD:290200	8/44 (18%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		zf-H2C2_2	370..394	CDD:290200	9/65 (14%)
		C2H2 Zn finger	385..405	CDD:275368	5/20 (25%)
		zf-H2C2_2	397..422	CDD:290200	9/31 (29%)
		C2H2 Zn finger	413..433	CDD:275368	7/24 (29%)
		C2H2 Zn finger	441..461	CDD:275368	6/24 (25%)
		zf-H2C2_2	453..478	CDD:290200	6/28 (21%)
		C2H2 Zn finger	469..489	CDD:275368	2/19 (11%)
		zf-H2C2_2	481..506	CDD:290200	4/24 (17%)
		C2H2 Zn finger	497..517	CDD:275368	6/20 (30%)
		zf-H2C2_2	510..533	CDD:290200	10/31 (32%)
		C2H2 Zn finger	525..545	CDD:275368	6/19 (32%)
		zf-H2C2_2	537..562	CDD:290200	14/24 (58%)
		C2H2 Zn finger	553..573	CDD:275368	9/19 (47%)
		zf-H2C2_2	565..590	CDD:290200	14/24 (58%)
		C2H2 Zn finger	581..601	CDD:275368	9/19 (47%)
		zf-H2C2_2	594..618	CDD:290200	10/23 (43%)
		C2H2 Zn finger	609..629	CDD:275368	4/19 (21%)
		C2H2 Zn finger	637..657	CDD:275368	8/21 (38%)
		zf-H2C2_2	649..674	CDD:290200	4/14 (29%)
		C2H2 Zn finger	665..685	CDD:275368
		zf-H2C2_2	677..702	CDD:290200
		C2H2 Zn finger	693..713	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100