DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42327 and PTPRZ1

DIOPT Version :9

Sequence 1:	NP_001036706.2	Gene:	CG42327 / 41401	FlyBaseID:	FBgn0259227	Length:	1429	Species:	Drosophila melanogaster
Sequence 2:	NP_002842.2	Gene:	PTPRZ1 / 5803	HGNCID:	9685	Length:	2315	Species:	Homo sapiens

Alignment Length:	1737	Identity:	372/1737 - (21%)
Similarity:	613/1737 - (35%)	Gaps:	534/1737 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 MVTQARFIAKRETTGLEQAMASTSTDPDIVKAPRESGIGREPVAIKAESDMFSSQTNIEDEKSAK 82
            :|...|..|..:....|..:::|:....|.....|:...|.|    .....||.:.::.: .|..
Human   442 IVNPGRDSATNQIRKKEPQISTTTHYNRIGTKYNEAKTNRSP----TRGSEFSGKGDVPN-TSLN 501

  Fly    83 TVDQTETQTASPKENLNVKQTTAAFEKNESSNTTESHLNGAQV---DPVKELKDTETSADTVK-- 142
            :..|..|:.|:.|:.....||......:....|:.|..:|::.   .|...|..|..|.:||.
Human   502 STSQPVTKLATEKDISLTSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAESLNTVSIT 566

  Fly   143 --EESSTTTTSQLDQNPTNVTDKK----STEA-QFKDERLSK------EILSTTTEQILLTEKAL 194
              ||.|..|:.:||   |...|..    :|.| .|..|.:|:      |...|.|..:|:.|.|.
Human   567 EYEEESLLTSFKLD---TGAEDSSGSSPATSAIPFISENISQGYIFSSENPETITYDVLIPESAR 628

  Fly   195 QKYVVITNS---------PLRGE----------AQPEI-------------------KDKTSKSA 221
            ......|:|         .:.|.          |||::                   .:||:||.
Human   629 NASEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIRVDESEKTTKSF 693

  Fly   222 TSEKSTLPLKPVT-IEVPSTTTEGVFNTTTTRSSDHGRSMQ----------YSSTTE-------- 267
            ::.........|| :|:|..:|...|.|..|..:....|.|          ||.||:
Human   694 SAGPVMSQGPSVTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNGETP 758

  Fly   268 -ESSRSSPA--SVTPMKLIPLPMTSTPSSTTSTS----TP---------------------LPTT 304
             :.|.||..  .|||:.|....:.:||::::|.|    ||                     ||.:
Human   759 LQPSYSSEVFPLVTPLLLDNQILNTTPAASSSDSALHATPVFPSVDVSFESILSSYDGAPLLPFS 823

  Fly   305 AVSFASN--------ENVIEESTSKSEVRQLP-------------------------------EK 330
            :.||:|.        ..::.:.||.:|..::|                               .:
Human   824 SASFSSELFRHLHTVSQILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSDVLSTTHAASE 888

  Fly   331 RAKFISENSTNAQQLTLPNTAEVWSLAGMKAVPKAP-----------------LTTTTSVPLLNH 378
            ..:|.||:....:.|.........|.|.|.|....|                 ::.::::|:.:.
Human   889 TLEFGSESGVLYKTLMFSQVEPPSSDAMMHARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDS 953

  Fly   379 TDL-------ANDIDMPLNKTEL-----------HKEKNLLDWMNIA-----MLPLT-------- 412
            ..:       :....:|:.|:.|           |......:|...:     :||.|
Human   954 VGVTYQGSLFSGPSHIPIPKSSLITPTASLLQPTHALSGDGEWSGASSDSEFLLPDTDGLTALNI 1018

  Fly   413 --PENRTEFVVRTTLDATEGATQATTEALVEETHSKSDITVGLE--------------------- 454
              |.:..||...|::...:      .:||     |||:|..|.|
Human  1019 SSPVSVAEFTYTTSVFGDD------NKAL-----SKSEIIYGNETELQIPSFNEMVYPSESTVMP 1072

  Fly   455 --QDNVT--------TARTMPSTPD--PGSMDLNMTTTTVRTQQL-EVP-----------LVKKM 495
              .|||.        |:.::.||..  |||  |..|||.|...:: :||           :.:..
Human  1073 NMYDNVNKLNASLQETSVSISSTKGMFPGS--LAHTTTKVFDHEISQVPENNFSVQPTHTVSQAS 1135

  Fly   496 SDAANAKLIEAVTEPQRETEAATEAATFVTLPEKLATFGITARVDSTQTELLNVTTAAAATESGE 560
            .|.:...::.|.:||.....|::|..                   |..|:||...|:|:.:....
Human  1136 GDTSLKPVLSANSEPASSDPASSEML-------------------SPSTQLLFYETSASFSTEVL 1181

  Fly   561 MS---KANSTDTLSAMTSTTTTTARPMSVEHVTPEQDMEAATSLATTAATSSGTTEAAATSSTTA 622
            :.   :|:..||| ..|......:.|:.||  ||:.|..::|.|....:.|:.:.....::|
Human  1182 LQPSFQASDVDTL-LKTVLPAVPSDPILVE--TPKVDKISSTMLHLIVSNSASSENMLHSTS--- 1240

  Fly   623 ATPVVSEAATAAEASATSEATTAATLS-----VATTAASTTEIAMKATQISNIRDDNDDNSNDVI 682
             .||...:.|:...||:.:..|.:..|     |...:.|:.::....            .|||.:
Human  1241 -VPVFDVSPTSHMHSASLQGLTISYASEKYEPVLLKSESSHQVVPSL------------YSNDEL 1292

  Fly   683 VATTKF-------PESEQAATTASV---EPTTTSVSVRVAGEVSTSIRPEIIVTSTRNSTI---- 733
            ..|...       |:......|..:   ||..|.        ::..|..:.|:|||::|..
Human  1293 FQTANLEINQAHPPKGRHVFATPVLSIDEPLNTL--------INKLIHSDEILTSTKSSVTGKVF 1349

  Fly   734 --VDTSTSATSVATPTQTEIAQISNEVNLEAVTVKTRDGLSDTNELRTAEKTDNAVNNSVAITES 796
              :.|..|.|.|:|.....|.  :..|.:.||: ..|||...:.:|....|..:.:::|   .:|
Human  1350 AGIPTVASDTFVSTDHSVPIG--NGHVAITAVS-PHRDGSVTSTKLLFPSKATSELSHS---AKS 1408

  Fly   797 DLGALATAVETNPT----------------------TTNSLLSDVSKL---SKEHESSL--ETNN 834
            |.| |....|...|                      :.:|......|:   |..||:||  :.|.
Human  1409 DAG-LVGGGEDGDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRESQEKVMNDSDTHENSLMDQNNP 1472

  Fly   835 IGEAPPESTTPAAPATVAVATDESTA-------APAATGGQEIVREGQHHDGQQVADEQDTEQQL 892
            |..:..|::......| :|::|..|.       :|:|.|..:     :|:||::..|.|.....|
Human  1473 ISYSLSENSEEDNRVT-SVSSDSQTGMDRSPGKSPSANGLSQ-----KHNDGKEENDIQTGSALL 1531

  Fly   893 -----AKTTMAVTTTTTS----ATTTTTSTTTTTTETPLTTTTMQPVEISL----------LDDS 938
                 :|....:|:...|    .|:.:.:...|:|:.....|..:..:..|          ...|
Human  1532 PLSPESKAWAVLTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQS 1596

  Fly   939 TTTTTTTPAPPVYFESSTVASTTIRSSTTMLPETTTASTQSPSEMPPTFMAPYPNELDHMQTNAQ 1003
            .|::.|:....|:..|...||.:...|...|.|...:..::
Human  1597 PTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKA------------------------ 1637

  Fly  1004 DNGTDVNVIIAITVSVIGVVALILLVAFLYLMRKRQKQTSY-----GQRCRPVSLDAYSLDNVS- 1062
                   ||..:.||.:..:.|::||..|...|| ..||::     ....|.:|.....:..:|
Human  1638 -------VIPLVIVSALTFICLVVLVGILIYWRK-CFQTAHFYLEDSTSPRVISTPPTPIFPISD 1694

  Fly  1063 VLGSVRRKG-----RDMRASKRTYGNAAFDDPSLRHNLLTASELARFVERRSDVFEEFRDVPQ-- 1120
            .:|::..|.     .|:.||                        :.|.|....:.|.:::|..
Human  1695 DVGAIPIKHFPKHVADLHAS------------------------SGFTEEFETLKEFYQEVQSCT 1735

  Fly  1121 ----IIARADEVPPGCEDKNRYANVIPLPETRVVLQRQGDDD--KTEYINANYVRGPRDAPNYYI 1179
                |.|.:...|.. :.||||.|::....:||.|.:..:.|  .|:|||||||.| .:.|..||
Human  1736 VDLGITADSSNHPDN-KHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDG-YNRPKAYI 1798

  Fly  1180 ACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATLDNHSSYGDYQVTLKHR 1244
            |.|.||:||..||||||||....||:..|:|.|.|..:|.:|.|    .|....||::.||.|..
Human  1799 AAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP----ADGSEEYGNFLVTQKSV 1859

  Fly  1245 EVKDRYAISTLVLKRV-------DGEES-RELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLKS 1300
            :|...|.:....|:..       .|..| |.:|.|.| :||:.|||....|::..:.:|     :
Human  1860 QVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKA-----A 1919

  Fly  1301 YSLEQANELREKSATLETSMDADGSKAEAGSTSSHEINGNISSRSGTRSQQGPLTVHCSPGTGRT 1365
            |:                                            .|...||:.||||.|.|||
Human  1920 YA--------------------------------------------KRHAVGPVVVHCSAGVGRT 1940

  Fly  1366 GTIIASDMAIRSLETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIY 1412
            ||.|..|..::.:: .:.:|:|...:.::|..|...|||:|||.||:
Human  1941 GTYIVLDSMLQQIQ-HEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIH 1986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:238006	94/290 (32%)
CG42327	NP_001036706.2	Y_phosphatase	1134..1415	CDD:278528	94/290 (32%)
PTPRZ1	NP_002842.2	PARM	1089..>1255	CDD:293666	42/193 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1123..1160		5/36 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1397..1523		28/135 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1543..1572		5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1584..1621		7/36 (19%)
		PTPc	1716..1991	CDD:214550	101/327 (31%)
		PTPc	1752..1991	CDD:238006	94/290 (32%)
		Substrate binding. /evidence=ECO:0000250	1933..1939		3/5 (60%)
		PTPc	2022..2280	CDD:214550
		PTPc	2050..2280	CDD:238006
		alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..401	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..462		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..507		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	628..650		2/21 (10%)
		MFMR	684..>763	CDD:285072	18/78 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900