DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42327 and PTP-ER

DIOPT Version :9

Sequence 1:	NP_001036706.2	Gene:	CG42327 / 41401	FlyBaseID:	FBgn0259227	Length:	1429	Species:	Drosophila melanogaster
Sequence 2:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster

Alignment Length:	1601	Identity:	287/1601 - (17%)
Similarity:	480/1601 - (29%)	Gaps:	616/1601 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 KTVDQTETQTASPKENLNVKQTTAAFEKNESSNTTESHLNGAQVDPVKE----LKDTETSADTV- 141
            |.:.|.:.::.||..|.:..:...:....:..||..   .|..||...|    |..:|.::.|:
  Fly   119 KRLSQYDRRSCSPHINTSSGEERVSGRGIDKENTMP---KGGSVDQDLENSLYLSKSEHNSPTIL 180

  Fly   142 -KEESSTT---TTSQLDQNP--------TNVTDKK---STEAQFKDERLSK-----EILSTTTEQ 186
             |:|||||   ..|:|..:|        .||:...   ...|.:|:....:     .::......
  Fly   181 FKDESSTTPGLEASRLSYSPKLLSSINNLNVSGSPLNIINSAGYKNGNFFRFPEIDHVVQDAPMD 245

  Fly   187 ILLTEKALQKYVVITNSPLRGEAQPEIKDKTSKSATSEKSTLPLKPVTIEVPSTTTEGVFNTTTT 251
            .:..|:|.::    ..||...| .||.:.:.|:...:.|:.                   |..|.
  Fly   246 TVCLEEATRR----DRSPALAE-PPEQQQQKSEGRKNRKNK-------------------NNLTI 286

  Fly   252 RSSDHGRSMQYSSTTEESSRSSPASVTPMKLIPLPMTSTPSSTTSTSTPLPTTAVSFASNE---- 312
            |.:|        ...:.||:.||        :|.|.|.|..||...:..|.:     |:||
  Fly   287 RITD--------VPIKNSSQPSP--------LPKPKTPTIKSTKEKARSLDS-----AANESELS 330

  Fly   313 ----NVIEESTSKSEVRQLPEKRAKFISENSTNAQQLTLPNTAEVWSLAGMKAVPKAPLTTTTSV 373
                |:.|...|..::.....:.:..:..:..:.||                  |.:.:.:|:..
  Fly   331 IVVHNITESHGSCDDMETGQSQPSTSVIHHHLHLQQ------------------PASAIHSTSLS 377

  Fly   374 PLLNHTDLANDIDMPLNKTELHKEKNLLDWMNIAMLPLTPENRTEFVVRTTLDATEGATQATTEA 438
            .|.:|..|||....|..|:   ...|..||    ::....:|..:
  Fly   378 RLDSHLSLANQRRTPRRKS---PGINTTDW----LMYHRKQNPYQ-------------------- 415

  Fly   439 LVEETHSKSDITVGLEQDNVTTARTMPSTPDPGSMDLNMTTTTVRTQQLEVPLVKKMSDAANAKL 503
             |:.||..|.....|:.|       ...||..|..:|....:.               |..:...
  Fly   416 -VQPTHCSSTTQSSLDSD-------ASLTPSLGDFELKSACSV---------------DGGSKFG 457

  Fly   504 IEAVTEPQ---RETEAATEAAT-FVTLPEKLATFGITARVDSTQTELLNVTTAAAATESGEMSKA 564
            |.|...|:   :..:....::| ..||||.|.              |:..:::....:.... |.
  Fly   458 IGASLAPRSAHKHNQLLHSSSTNLKTLPECLT--------------LVEFSSSGGGPKESPF-KQ 507

  Fly   565 NSTD----TLSAMTSTTTTTARPMSVEHVTPEQDMEAATSLATTAATSSGTTEAAATSSTTAATP 625
            .|.|    ||.|.|:.:|::...:        |...:..||.....:|.|....:..|.:..:..
  Fly   508 KSMDLPMPTLQAKTTVSTSSMNLL--------QRRGSNHSLTLNLHSSCGNLMNSGLSHSNYSLG 564

  Fly   626 VVSEAATAAEASATSEATTAATLSVATTAASTTEIAMKATQISNIRDDNDDNSNDVIVATTKFPE 690
            .:..    :::|...:|.||                      |.||.|             :.|:
  Fly   565 SILN----SKSSCNLDAGTA----------------------SQIRAD-------------QLPQ 590

  Fly   691 SEQAATTASVEPTTTSVSVRVAGEVSTSIRPEIIVTSTRNSTIVDTSTSATSVATPTQTEIAQIS 755
            |.   ...|.:.:...:..|.....|.:::       |.::|   ||....:.....|.:.|.:|
  Fly   591 SH---LLGSSQGSRQGLFRRRGSNHSITLK-------TGHTT---TSCGDLNSMQQLQQQQAMLS 642

  Fly   756 ----NEVNLEAVTVKTRDGLSDTNELRTAEK---TDNAVNNSVAITESDL--GALATAVE----T 807
                |.:|:.  |..|..|....:.:.|.::   .....|.|:.:....:  ||..|.::    .
  Fly   643 AEKYNRLNMR--TNSTGSGSGSGSNVPTPKRGLLERRGSNQSLTLNMGSILGGAAGTEIQMTDIV 705

  Fly   808 NPTTTNSLLSDVSKLSKEHESS-LETNNIGEAPPESTTPAAPATVAVATDESTAAPAATGGQEIV 871
            .|..|  :.|..:.....|:.. ..|.|:..:...|...........|:|
  Fly   706 QPKVT--VCSCAAANQAPHQRKFFSTENLNSSKANSQKFFGQVCFGSASD--------------- 753

  Fly   872 REGQHHDGQQVADEQDT--EQQLAKTTMAVTTTTTSATTTTTSTTTTTTETPLTTTTMQPVEIS- 933
                    .|...:||:  |.|....|.....|..:..|...|..||:.|..:...::|.::.:
  Fly   754 --------LQPNPQQDSVREDQAIGATCTCAGTVRNIMTRPLSPQTTSEEFKIYLASIQMLQSAS 810

  Fly   934 -------------LLDDS-TTTTTTTPAPPVYFESSTVASTTIRSSTTMLPETTTASTQSPSEMP 984
                         :.|.| .|.......|||...:    :..:.:.|.|:|         ||...
  Fly   811 NPLNQFDLIRLNYVFDHSYQTNRNIIEQPPVLGSN----ARDVETPTDMVP---------PSSED 862

  Fly   985 PTFMAPYPNELDHMQTNAQDNGTDVNVIIAITVSVIGVVALILLVAFLYLMRKRQKQTSYGQRCR 1049
            ...:|.|                                                 ||...:..:
  Fly   863 SELLASY-------------------------------------------------QTVVSRMAQ 878

  Fly  1050 PVSLDAYSLDNVSVLGSVRRKGRDMRASKRTYGNAAFDDPSLRHNLLTASELARFVERRSDVFEE 1114
            |:                                     |.|:.|     |..|...   |:.:|
  Fly   879 PI-------------------------------------PELKEN-----EQKRIFR---DLHKE 898

  Fly  1115 FRDVPQIIARADEVPP--GCEDKNRYANVIPLPETRVVLQRQ--------GDDDKTE-------- 1161
            |.|:|   ....|.|.  |.:.||||..::|...:||:|:.:        |:..:|.
  Fly   899 FWDLP---LNHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDL 960

  Fly  1162 -YINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRV---------------------- 1203
             ||||||::||......|:|.|.||.:|..:||.||::...|.
  Fly   961 PYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQ 1025

  Fly  1204 -----IIQATDLSENGIERCAEYLP------------------PSATLDNHSSY----------- 1234
                 |:..|:.:|...::||.|.|                  .:|..|....|
  Fly  1026 QYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVV 1090

  Fly  1235 -----GDYQVTLKHREV-------------------------------KDRYAISTLVLK---RV 1260
                 .||:::.:|..|                               ::.|::..|||.   ||
  Fly  1091 ASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRV 1155

  Fly  1261 DGEESRELT-----HYWY-KWPEAGVPAEEAPIIAMLLEARSSLKSYSLEQANELREKSATLETS 1319
            ....|..|.     |||| .||:...|.:    |..||:  :.|...:|.:.          |:.
  Fly  1156 PQSASYHLQKIYCYHYWYPDWPDHHSPRD----INTLLD--TCLHVLNLGKC----------ESE 1204

  Fly  1320 MDA-DGSKAEAGSTSSHEINGNISSRSGTRSQQG------PL-TVHCSPGTGRTGTIIASDMAIR 1376
            .|. |.:::|.        |.:::::.....||.      || .:|||.|.||||...|...|:|
  Fly  1205 FDIYDDTRSER--------NAHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVR 1261

  Fly  1377 SL--------------------------------------------------------------- 1378
            .|
  Fly  1262 QLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRL 1326

  Fly  1379 -ETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY 1418
             :.|...||:..:|..:|..|...||..||||.|::...:|
  Fly  1327 PKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAICLY 1367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:238006	97/470 (21%)
CG42327	NP_001036706.2	Y_phosphatase	1134..1415	CDD:278528	97/470 (21%)
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	97/471 (21%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	97/470 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000