DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42327 and Lar

DIOPT Version :9

Sequence 1:	NP_001036706.2	Gene:	CG42327 / 41401	FlyBaseID:	FBgn0259227	Length:	1429	Species:	Drosophila melanogaster
Sequence 2:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster

Alignment Length:	1603	Identity:	317/1603 - (19%)
Similarity:	504/1603 - (31%)	Gaps:	515/1603 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 SGIGREPVAIKAE----------SDMFSSQTNIEDEKSAKTV-DQTETQTASPKENLNVKQTTAA 106
            :.|||.|.:..|.          :.|.|:..|::    .:|: ..|...|..|.|..|.:.|...
  Fly   396 NNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQ----VRTLSSSTMVITWEPPETPNGQVTGYK 456

  Fly   107 FEKNESSNTTESHLNGAQVDPVKELKDTETSADTVKEESSTTTTSQLDQNPTNVTDKKSTEAQFK 171
            .....:||..|:..|...||                 .|..||.|:|
  Fly   457 VYYTTNSNQPEASWNSQMVD-----------------NSELTTVSEL------------------ 486

  Fly   172 DERLSKEILSTTTEQILLTEKALQKYVVI----TNSPLRGEAQPEIKDKTSK-SATSEKSTLPLK 231
                        |...:.|.: :|.|..:    .::|::.:||..:..:.|. .||....|
  Fly   487 ------------TPHAIYTVR-VQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGET---- 534

  Fly   232 PVTIE--VPSTTTEGV------FNTTTTRSSDHGR---------------SMQYSSTTEESSRSS 273
            .||::  .|:.::|.:      :|.|....:.|.|               ::.|......|.|..
  Fly   535 AVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGE 599

  Fly   274 PASVTPMKLIPLPMTSTPSSTTSTSTPLPTTAVSF------ASNENVIEESTSKSEV-RQLPEKR 331
            .|:..|:.:......:.|.:.|:.:|...|.::|:      .||..:|.......|| |:..|..
  Fly   600 GATTPPIPVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEAT 664

  Fly   332 AKFISENSTNAQQLTLPNTAEVWSLAGMKAVPKAPLTTTTSVPLLNHT--DLANDID----MPLN 390
            ...::..|....:|......::|.||| .:|...|    .|.|::..|  |:..|..    .|||
  Fly   665 TMTLNMTSIVLDELKRWTEYKIWVLAG-TSVGDGP----RSHPIILRTQEDVPGDPQDVKATPLN 724

  Fly   391 KTELH--------KEKN----------------------------LLDWMNIAMLPLTPENRTEF 419
            .|.:|        |::|                            ::|.:...:..|.|:.:...
  Fly   725 STSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSI 789

  Fly   420 VVRTTLDATEGATQAT------------------------------------------------- 435
            .|.......:|...|.
  Fly   790 QVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRW 854

  Fly   436 ---TEALVEETHSKSDIT----------------------VGLEQDNVTTARTMPSTPDPGSMDL 475
               .:||.||..|...:|                      :|:.|:.|...:|...|  ||....
  Fly   855 GVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGT--PGGPPS 917

  Fly   476 NMTTTTVRTQQLEVPLVKKMSDAANAKLIEAVTEPQRETEAATEAATFVTLPEKLATFGITARVD 540
            |:   |:|.|..:|             |......|.||...                 ||..|.|
  Fly   918 NI---TIRFQTPDV-------------LCVTWDPPTREHRN-----------------GIITRYD 949

  Fly   541 STQTELL--------NVTTAAAATESGEMSKANSTDTLSAMTSTTTTTARPMSVE-HVTPEQDME 596
            ....:.:        |:|...|...:.|    .:|:.:..:.:.|...|.|.|.: .|..|:||
  Fly   950 VQFHKKIDHGLGSERNMTLRKAVFTNLE----ENTEYIFRVRAYTKQGAGPFSDKLIVETERDM- 1009

  Fly   597 AATSLATTAATSSGTTEAAATSSTTAATPVVSEAATAAEASATSEATTAATLSVATTAASTTEIA 661
                                           ..|..:.:|.||||.|........|:....  :.
  Fly  1010 -------------------------------GRAPMSLQAEATSEQTAEIWWEPVTSRGKL--LG 1041

  Fly   662 MKATQISNIRDDNDDNSNDVIVATTKFPESEQAATTASVEPTTTSVSV-------RVAGEVSTSI 719
            .|........:|.||.....:..|    ||..............:::.       |::.:|:..|
  Fly  1042 YKIFYTMTAVEDLDDWQTKTVGLT----ESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRI 1102

  Fly   720 RPEIIVTSTRNSTIVDTSTSATSVATPTQTEIAQISNEVNLEAVTV-KTRDGLSDTNELRTAE-- 781
            :||.:..:.|..   |.||.:.:::......:..::.:::.:|:.| ....|.|.|..:...|
  Fly  1103 KPEDVPLNLRAH---DVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREII 1164

  Fly   782 -----KTDNAVNNSVAITESDLGALATAVETNPTTTNSLLSDVSKLSKEHESSLETNNIGEAPPE 841
                 || :.:|                 |.:|.||.::  :||.:..::         ...||.
  Fly  1165 LKHYVKT-HTIN-----------------ELSPFTTYNV--NVSAIPSDY---------SYRPPT 1200

  Fly   842 STTPAAPATVAVATDESTAAP---AATGGQEIVREGQHHDGQQVADEQDTEQ--QLAKTTMAVTT 901
            ..|    .|..:|..:....|   ....|:||:          |...|.:|:  .::...:.|..
  Fly  1201 KIT----VTTQMAAPQPMVKPDFYGVVNGEEIL----------VILPQASEEYGPISHYYLVVVP 1251

  Fly   902 TTTSATTTTTSTTTTTTETPLTTTTMQP-----------------VEISLLDDSTTTT------- 942
            ...|..........|....|......:|                 ..:...||....|
  Fly  1252 EDKSNLHKIPDQFLTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLERE 1316

  Fly   943 ----------TTTPAPPVYFES--STVASTTIRSSTTMLPETTTASTQSPSEMPPTFMAPYPNEL 995
                      ..||...:|..|  |...|..:|.:             .|.|.|......:|.|.
  Fly  1317 KRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREA-------------PPGERPHRPDPNWPAEP 1368

  Fly   996 DHMQTNAQDNGTDVNVIIAITVSVIGV-VALILLVAFLYLMRKRQKQTSYGQRCRPVSLDAYSLD 1059
            :......:|....:.|::.:.||...| .|||:|..   :.|:||...:..|......|.|..|.
  Fly  1369 EVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCV---VKRRRQPCKTPDQAAVTRPLMAADLG 1430

  Fly  1060 NVSVLGSVRRKGRDMRASKRTYGNAAFDDPS-LRHNLLTASELARFVER-RSDVFEEFRDVPQII 1122
                .|.......|||       ...|..|. :.|..:..||.|..:|| :|:..::|..
  Fly  1431 ----AGPTPSDPVDMR-------RLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQ----- 1479

  Fly  1123 ARADEVPPGCE------------DKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDAP 1175
             ..:.:.||.:            .|||||||.....:||.|........::||||||..|.| ..
  Fly  1480 -EYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYR-KH 1542

  Fly  1176 NYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATLDNHSSYGDYQVT 1240
            |.|:|.|.||:.|..|||||.||.::..|:..|.|.|....:|.:|.|...|    .:||...||
  Fly  1543 NAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGT----ETYGQIFVT 1603

  Fly  1241 LKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLKSYSLE 1304
            :...:....|:|.|..|.|....:.||:....: .||:.|||...||.:..|...|:.
  Fly  1604 ITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRAL------- 1661

  Fly  1305 QANELREKSATLETSMDADGSKAEAGSTSSHEINGNISSRSGTRSQQGPLTVHCSPGTGRTGTII 1369
                                                      |..:.||:.||||.|.||||..|
  Fly  1662 ------------------------------------------TPPESGPVIVHCSAGVGRTGCYI 1684

  Fly  1370 ASDMAIRSLETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIY 1412
            ..|..:..::..| .:||...|..:|..|...|||::||.||:
  Fly  1685 VIDSMLERMKHEK-IIDIYGHVTCLRAQRNYMVQTEDQYIFIH 1726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:238006	87/280 (31%)
CG42327	NP_001036706.2	Y_phosphatase	1134..1415	CDD:278528	87/280 (31%)
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470	4/7 (57%)
		FN3	423..514	CDD:238020	25/142 (18%)
		FN3	520..610	CDD:238020	17/93 (18%)
		FN3	616..707	CDD:238020	22/95 (23%)
		FN3	712..810	CDD:238020	14/97 (14%)
		FN3	832..907	CDD:238020	9/74 (12%)
		FN3	914..1005	CDD:238020	23/127 (18%)
		FN3	1012..1101	CDD:238020	17/94 (18%)
		fn3	1106..1198	CDD:278470	19/123 (15%)
		PTPc	1476..1731	CDD:214550	90/312 (29%)
		PTPc	1503..1731	CDD:238006	87/279 (31%)
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100