DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42327 and Ptpn5

DIOPT Version :9

Sequence 1:	NP_001036706.2	Gene:	CG42327 / 41401	FlyBaseID:	FBgn0259227	Length:	1429	Species:	Drosophila melanogaster
Sequence 2:	XP_038965611.1	Gene:	Ptpn5 / 29644	RGDID:	3448	Length:	613	Species:	Rattus norvegicus

Alignment Length:	728	Identity:	163/728 - (22%)
Similarity:	272/728 - (37%)	Gaps:	227/728 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   810 TTTNSLLSDVSKLSKEHESSLETNNIGEAPPESTTPAAPATVAVATDESTAAPAATGG------Q 868
            ::::||.|..|.|:||                    :.......:..||.||..:.||      .
  Rat     4 SSSSSLSSSSSSLTKE--------------------SGDRMAQWSEKESQAADDSKGGTLDMCCS 48

  Fly   869 EIVREGQHHDGQQVADEQDTEQQLAKTTMAVTTTTTSATTTTTSTTTTTTETPLTTTTMQPVEIS 933
            :.:...||  |..|.|:...:.:|               .:...:|..:...|      ||||:.
  Rat    49 KRLLGWQH--GPPVGDQIPGQDKL---------------LSKKRSTEDSKGLP------QPVEMG 90

  Fly   934 LLDDS---TTTTTTTPAPPVYFESSTVA----------STTIRSSTTMLP--------------- 970
            .||:.   .:.....|.||....|....          |.|:|||..:..
  Rat    91 GLDEGEGLPSKQRELPPPPPSPPSEPAQKLPPQGAGSHSLTVRSSLCLFAASQLLLACGVLWLSG 155

  Fly   971 ------ETTTASTQSPSEMPPTFMAPYPNELDHMQTNAQDN----GTDVNVIIAITVSVIGVVAL 1025
                  :|||....|...:           |:|:...|...    ||...:::::||| :|::..
  Rat   156 HGHSWLQTTTDLIFSSLTV-----------LNHLGPAAWLGSGTWGTPSLLLVSLTVS-LGIITT 208

  Fly  1026 ILLVAFLYLMR------------------KRQKQTSYGQRC-RPVSLDAYSLD------------ 1059
            ::    .:|::                  .||...:|.:.. ..|..|...||
  Rat   209 LV----WHLLKTPPEPPVPLPPEDRRQSVSRQPSFTYSEWMEEKVEDDFLDLDAVPETPVFDCVM 269

  Fly  1060 -----------NVSVLGSVRRKGRDMR---------ASKRTYGNAAFD-DPSLRHNLLTASELAR 1103
                       .|..:|...|:|.::.         .::..:|..... :.|....||:||.:.|
  Rat   270 DIKPEADPTSLTVKSMGLQERRGSNVSLTLDMCTPGCNEEGFGYLVSPREESAHEYLLSASRVLR 334

  Fly  1104 ---FVERRSDVF---EEFRDVPQIIARADEVP-PGCEDKNRYANVIPLPETRVVLQRQGDDDK-T 1160
               ..|:..|.|   .||.::|.......|.. ||...||||..::|.|.:||.|.....:|. :
  Rat   335 AEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVRLTSPDPEDPLS 399

  Fly  1161 EYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPS 1225
            .||||||:||.......|||.|.|:.||.:|||||:|::::.:|:..|::.|.. |:|.||.|..
  Rat   400 SYINANYIRGYNGEEKVYIATQGPIVSTVADFWRMVWQERTPIIVMITNIEEMN-EKCTEYWPEE 463

  Fly  1226 ATLDNHSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIA 1289
            ..:     :...::|::.....:.|.:..:.|:|  |.|.|.|.|||: .||:...|....|::.
  Rat   464 QVV-----HDGVEITVQKVIHTEDYRLRLISLRR--GTEERGLKHYWFTSWPDQKTPDRAPPLLH 521

  Fly  1290 MLLEARSSLKSYSLEQANELREKSATLETSMDADGSKAEAGSTSSHEINGNISSRSGTRSQQG-- 1352
            ::.|         :|:|.:                                         |:|
  Rat   522 LVRE---------VEEAAQ-----------------------------------------QEGPH 536

  Fly  1353 --PLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVA 1415
              |:.||||.|.||||..||:.:..:.|.. :..|||.:....:|:.|...:||.|||:|::...
  Rat   537 CSPIIVHCSAGIGRTGCFIATSICCQQLRR-EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHAM 600

  Fly  1416 SMYAAKITNLSND 1428
            |:|..:::..|::
  Rat   601 SLYEKQLSLQSSE 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:238006	83/286 (29%)
CG42327	NP_001036706.2	Y_phosphatase	1134..1415	CDD:278528	83/286 (29%)
Ptpn5	XP_038965611.1	PTPc-N5	346..603	CDD:350461	91/315 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566624at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910