DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42327 and Ptpn11

DIOPT Version :9

Sequence 1:	NP_001036706.2	Gene:	CG42327 / 41401	FlyBaseID:	FBgn0259227	Length:	1429	Species:	Drosophila melanogaster
Sequence 2:	NP_001171064.1	Gene:	Ptpn11 / 25622	RGDID:	3447	Length:	597	Species:	Rattus norvegicus

Alignment Length:	389	Identity:	108/389 - (27%)
Similarity:	166/389 - (42%)	Gaps:	97/389 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1061 VSVLGSVRRKGRDMRASKRTYGNAAFDDPSLRHNLLTASELARFVERRSDV----FEEFRDVPQ- 1120
            |..||:|.:..:.:..::.   |||..:..:|       ||::..|....|    :|||..:.|
  Rat   203 VETLGTVLQLKQPLNTTRI---NAAEIESRVR-------ELSKLAETTDKVKQGFWEEFETLQQQ 257

  Fly  1121 ----IIARADEVPPGCEDKNRYANVIPLPETRVVLQRQGDDDK--TEYINANYVRGPRDAPNY-- 1177
                :.:|.:......::||||.|::|...||||| ..||.::  ::|||||.:     .|.:
  Rat   258 ECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVL-HDGDPNEPVSDYINANII-----MPEFET 316

  Fly  1178 ----------YIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATLDNHS 1232
                      |||.|..|::|.:|||||::::.||||:..|...|.|..:|.:|.|....|   .
  Rat   317 KCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDECAL---K 378

  Fly  1233 SYGDYQVTLKHREVKDRYAISTLVLKRV-----DGEESRELTHYWYK-WPEAGVPAEEAPIIAML 1291
            .||..:|..........|.:..|.|.:|     .|...|.:..|.:: ||:.|||::...::..|
  Rat   379 EYGVMRVRNVRESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFL 443

  Fly  1292 LEARSSLKSYSLEQANELREKSATLETSMDADGSKAEAGSTSSHEINGNISSRSGTRSQQGPLTV 1356
                           .|:..|.   |:.:||                             ||:.|
  Rat   444 ---------------EEVHHKQ---ESIVDA-----------------------------GPVVV 461

  Fly  1357 HCSPGTGRTGTIIASDMAIRSLETP--KRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY 1418
            |||.|.|||||.|..|:.|..:...  ...:|:|:.:..||..|:..|||:.||.|||.....|
  Rat   462 HCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHY 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:238006	90/302 (30%)
CG42327	NP_001036706.2	Y_phosphatase	1134..1415	CDD:278528	90/302 (30%)
Ptpn11	NP_001171064.1	SH2_N-SH2_SHP_like	5..103	CDD:198203
		SH2_C-SH2_SHP_like	111..218	CDD:198185	4/14 (29%)
		PTPc	246..524	CDD:214550	95/333 (29%)
		PTPc	276..523	CDD:238006	90/302 (30%)
		Substrate binding. /evidence=ECO:0000250	463..469		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000