DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42327 and Ptprz1

DIOPT Version :9

Sequence 1:	NP_001036706.2	Gene:	CG42327 / 41401	FlyBaseID:	FBgn0259227	Length:	1429	Species:	Drosophila melanogaster
Sequence 2:	NP_037212.2	Gene:	Ptprz1 / 25613	RGDID:	3455	Length:	2316	Species:	Rattus norvegicus

Alignment Length:	1732	Identity:	351/1732 - (20%)
Similarity:	609/1732 - (35%)	Gaps:	531/1732 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ETTGLEQAMASTST-----DPDIVKAPRESGIG---------REPV---AIKAESDMFSSQTNIE 76
            |.|||.....|.:.     :|.:......:.:|         |.|.   ....:||:.::..|..
  Rat   439 EDTGLNPGRDSATNQIRKKEPQVSTTTHYNHMGTKYNEAKTNRSPTKGSEFSGKSDVLNTSLNPT 503

  Fly    77 DEKSAKTVDQTETQTASPKE---NL---NVKQTTAA----------FEKNESSNTTESHLNGAQV 125
            .::.|:.  ..|.:.:.|.:   ||   :|:.|:|:          |.:...|.|.|| ||...:
  Rat   504 SQQVAEF--NPEREMSLPSQIGTNLPPHSVEGTSASLNSGSKTLLVFPQMNLSGTAES-LNMVSI 565

  Fly   126 DPVKELKDTETSADTVKEE---------------------SSTT--TTSQLDQNPTNVTD----- 162
            ...||:     |||..:||                     |||.  :|..|....|:.:|
  Rat   566 TEYKEV-----SADLSEEENLLTDFKLDSGADDSSGSSPASSTVPFSTDNLSHGYTSSSDTPEAV 625

  Fly   163 ------------------KKSTEAQFKDERLSKEI-------LSTTTEQILLTEKALQKYVVITN 202
                              ...:|...||..|...:       |:|.:|    |....:.::.:.:
  Rat   626 TYDVLRPESTRNALEDSAPSGSEESLKDPSLEGSVWFPGSTDLTTQSE----TGSGREGFLQVNS 686

  Fly   203 SPLRGEAQPEIKDKTSKSATSEK------------STLPLKPVTIE----VPST------TTEGV 245
            :..:.:...|..:..|..||:.:            ||....|..:.    .||:      .|..:
  Rat   687 TDFQVDESRETTETFSPDATASRGPSVTDMEMPHYSTFAYPPTEVTPHAFTPSSRPLDLAPTSNI 751

  Fly   246 FNTTTTRSSDHGRSMQYSSTTEESSRSSPA--SVTPMKLIPLPMTSTPSSTTSTS----TPL-PT 303
            .::.||:...:|      .|..:.|.||..  .|||:.|....:.:||::::|.|    ||: |:
  Rat   752 LHSQTTQPVYNG------ETPLQPSYSSEVFPLVTPLLLDNQTLNTTPAASSSDSALHATPVFPS 810

  Fly   304 TAVSFASNENVIEESTSKSEVRQLPEKRAKFISE--NSTNAQQLTLPNTAEVWS----------- 355
            ..|||   ::::   :|..:...||...|.|.|:  :..:....|||.......
  Rat   811 VGVSF---DSIL---SSYDDAPLLPFSSASFSSDLFHHLHTVSQTLPQVTSAAERDELSLHASLL 869

  Fly   356 LAGMKAVPKAPLTTTTSV--------------------PLLNHTDLANDIDMPLNKTELHKEKN- 399
            :||...:.:..|...:.|                    .:|..|.:.:.|:.|.:...:|...:
  Rat   870 VAGGDLLLEPSLVQYSDVMSHQVTIHAASDTLEFGSESAVLYKTSMVSQIESPSSDVVMHAYSSG 934

  Fly   400 -----------------------LLDWMNIA---MLPLTPEN----RTEFVVRTTL--------- 425
                                   :.|.:.:|   .|.:.|.:    .:.|:..|..
  Rat   935 PETSYAIEGSHHVLTVSSSSAIPVHDSIGVADQGSLLINPSHISLPESSFITPTASLLQLPPALS 999

  Fly   426 -DATEGATQATTEALVEETHSKSDITVGLEQDNVT--------TARTMPSTPD-----PGSM--- 473
             |.......:.:|.|:.:|.       ||...|::        |..|..|..|     .|.|
  Rat  1000 GDGEWSGASSDSELLLPDTD-------GLRTLNMSSPVSVADFTYTTSVSGDDIKPLSKGEMMYG 1057

  Fly   474 ---DLNMTTTTVRTQQLEVPLVKKMSDAAN---------------------AKLIEAVTE----- 509
               :|.|::.:......:..:|.||||..|                     ..|:..:|:
  Rat  1058 NETELKMSSFSDMAYPSKSTVVPKMSDIVNKWSESLKETSVSVSSINSVFTESLVYPITKVFDQE 1122

  Fly   510 ---------PQRETEAATEAATFVTLPEKLATFGITARVDSTQTELLNVTTAAAATESGEMSKAN 565
                     |.:.|..|::|:....|...|:|....|..|:..:|:|:.:|.....|:
  Rat  1123 ISRVPEIIFPVKPTHTASQASGDTWLKPGLSTNSEPALSDTASSEVLHPSTQPLLYEA------- 1180

  Fly   566 STDTLSAMTSTTTTTARPMSVEHVT----PEQDMEAATSLATTAATSSGTTEAAAT-------SS 619
                           |.|.:.|.:.    |..|::  |.|.|  |..||..:...|       ||
  Rat  1181 ---------------ASPFNTEALLQPSFPASDVD--TLLKT--ALPSGPRDPVLTETPMVEQSS 1226

  Fly   620 TTAATPVVSEAATAAEASATSEATTAATLSVATTAASTTEIAMKATQISNIRDDNDD-------- 676
            ::.:.|:.||:|:   :.:|...|:...|:::.:....|  :::...:.:.|::..:
  Rat  1227 SSMSLPLASESAS---SKSTLHFTSVPVLNMSPSDVHPT--SLQRLTVPHSREEYFEQGLLKSKS 1286

  Fly   677 --------NSNDVIVATTKF-------PESEQAATTASV---EPTTTSVSVRVAGEVSTSIRPEI 723
                    :|:|....|...       |:...|..|..:   ||..|.:|..|..| ...:.|||
  Rat  1287 PQQVLPSLHSHDEFFQTAHLDISQAYPPKGRHAFATPILSIDEPQNTLISRLVYSE-DIFMHPEI 1350

  Fly   724 IVTSTRNSTIVDTSTSATSVATPTQTEIAQISNEVNLEAVTVKTRDGLSDTNEL----RTAEKTD 784
            .:|   :..:....|:.:.|...|...:...|..:::..|:....|.::.|..|    .|::.|.
  Rat  1351 SIT---DKALTGLPTTVSDVLIATDHSVPLGSGPISMTTVSPNRDDSVTTTKLLLPSKATSKPTH 1412

  Fly   785 NAVNNSVAI----------------TESDLGALATAVETNP--TTTNSLLSDVSKLSKEHESSL- 830
            :|.:::..:                .:||...:...:..:|  .:...:::|    |...||||
  Rat  1413 SARSDADLVGGGEDGDDYDDDDYDDIDSDRFPVNKCMSCSPYRESQEKVMND----SDTQESSLV 1473

  Fly   831 -ETNNIGEAPPESTTPAAPATVAVATDESTAAPAATGGQEIVREGQHHDGQQVADEQDTEQQL-- 892
             :::.|.....|:|......|.....|:|   |..:....::.: :|:||::..|.|.....|
  Rat  1474 DQSDPISHLLSENTEEENGGTGVTRVDKS---PDKSPPPSMLPQ-KHNDGREDRDIQMGSAVLPH 1534

  Fly   893 ---AKTTMAVTTTTTSATTTTTSTTTTTTETPLTTTTMQPVEISLLD-DSTTTTTTTPAPPVYFE 953
               :|....:|:...|.:...||.:....|   |:|.....:::..| |.......|...|....
  Rat  1535 TPGSKAWAVLTSDEESGSGQGTSDSLNDNE---TSTDFSFPDVNEKDADGVLEADDTGIAPGSPR 1596

  Fly   954 SSTVASTTIRSSTTMLPETTTASTQSPSEMPPTFMAPYPNELDHMQTNAQDNGTDVNVIIAITVS 1018
            |||.:.|:..|..:...|...:::...|.:         ...:.:::..:      .||..:.||
  Rat  1597 SSTPSVTSGHSGVSNSSEAEASNSSHESRI---------GLAEGLESEKK------AVIPLVIVS 1646

  Fly  1019 VIGVVALILLVAFLYLMRKRQKQTSYGQRCRPVSLDAYSLDNVSV----------------LGSV 1067
            .:..:.|::||..|...||..:...:           |..||.|.                :|::
  Rat  1647 ALTFICLVVLVGILIYWRKCFQTAHF-----------YLEDNTSPRVISTPPTPIFPISDDIGAI 1700

  Fly  1068 RRKG-----RDMRASKRTYGNAAFDDPSLRHNLLTASELARFVERRSDVFEEFRDVPQ------I 1121
            ..|.     .|:.||.                        .|.|....:.|.:::|..      |
  Rat  1701 PIKHFPKHVADLHASN------------------------GFTEEFETLKEFYQEVQSCTVDLGI 1741

  Fly  1122 IARADEVPPGCEDKNRYANVIPLPETRVVLQRQGDDD--KTEYINANYVRGPRDAPNYYIACQAP 1184
            .|.:...|.. :.||||.|::....:||.|.:..:.|  .|:|||||||.| .:.|..|||.|.|
  Rat  1742 TADSSNHPDN-KHKNRYVNIVAYDHSRVKLTQLAEKDGKLTDYINANYVDG-YNRPKAYIAAQGP 1804

  Fly  1185 LESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATLDNHSSYGDYQVTLKHREVKDR 1249
            |:||..||||||||....||:..|:|.|.|..:|.:|.|    .|....||.:.|..|:.:|...
  Rat  1805 LKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP----TDGSEEYGSFLVNQKNVQVLAY 1865

  Fly  1250 YAISTLVLKRV-------DGEES-RELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLKSYSLEQ 1305
            |.:....|:..       .|..| |.:|.|.| :||:.|||....|::|.:
  Rat  1866 YTVRNFTLRNTKIKKGSQKGRSSGRLVTQYHYTQWPDMGVPEYSLPVLAFV-------------- 1916

  Fly  1306 ANELREKSATLETSMDADGSKAEAGSTSSHEINGNISSRSGTRSQQGPLTVHCSPGTGRTGTIIA 1370
                 .|:|                              ...|...||:.||||.|.|||||.|.
  Rat  1917 -----RKTA------------------------------QAKRHAVGPVVVHCSAGVGRTGTYIV 1946

  Fly  1371 SDMAIRSLETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIY 1412
            .|..::.:: .:.:|:|...:.::|..|...|||:|||.||:
  Rat  1947 LDSMLQQIQ-HEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIH 1987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:238006	94/290 (32%)
CG42327	NP_001036706.2	Y_phosphatase	1134..1415	CDD:278528	94/290 (32%)
Ptprz1	NP_037212.2	alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..401	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..499		11/59 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..537		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	586..624		7/37 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..720		12/87 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1141..1172		8/30 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1228		7/25 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1401..1521		23/127 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1545..1622		17/79 (22%)
		PTPc	1717..1992	CDD:214550	101/327 (31%)
		PTPc	1753..1992	CDD:238006	94/290 (32%)
		Substrate binding. /evidence=ECO:0000250	1934..1940		3/5 (60%)
		PTPc	2023..2281	CDD:214550
		PTPc	2051..2281	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900