DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42327 and Ptpn22

DIOPT Version :9

Sequence 1:	NP_001036706.2	Gene:	CG42327 / 41401	FlyBaseID:	FBgn0259227	Length:	1429	Species:	Drosophila melanogaster
Sequence 2:	NP_033005.1	Gene:	Ptpn22 / 19260	MGIID:	107170	Length:	802	Species:	Mus musculus

Alignment Length:	337	Identity:	94/337 - (27%)
Similarity:	148/337 - (43%)	Gaps:	66/337 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1098 ASELARFVERRSDVFEEFRDVPQIIARADEVPPGCEDKNRYANVIPLPETRVVLQRQGDDDKTEY 1162
            |||..: ::|:|..::..:..|..:|:.    |....||||.:::|...:.|.|.....|:.:.|
Mouse    25 ASEFLK-LKRQSTKYKADKIYPTTVAQR----PKNIKKNRYKDILPYDHSLVELSLLTSDEDSSY 84

  Fly  1163 INANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEY-LPPSA 1226
            |||::::|.. .|..|||.|.||.:|..||||||||.:..||:.|....|.|.::|..| ..|..
Mouse    85 INASFIKGVY-GPKAYIATQGPLSTTLLDFWRMIWEYRILVIVMACMEFEMGKKKCERYWAEPGE 148

  Fly  1227 TLDNHSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWYK-WPEAGVPAEEAPIIAM 1290
            |   ...:|.:.::.:..:.|..|.|.|  ||.....|:|.:..:.|| ||:..||:...||:.:
Mouse   149 T---QLQFGPFSISCEAEKKKSDYKIRT--LKAKFNNETRIIYQFHYKNWPDHDVPSSIDPILQL 208

  Fly  1291 LLEARSSLKSYSLEQANELREKSATLETSMDADGSKAEAGSTSSHEINGNISSRSGTRSQQGPLT 1355
            :.:.|.            .:|....                                     |:.
Mouse   209 IWDMRC------------YQEDDCV-------------------------------------PIC 224

  Fly  1356 VHCSPGTGRTGTIIASD---MAIRSLETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASM 1417
            :|||.|.||||.|.|.|   |.::....|| :..:..|:..:|..|.|.|||:||||.:|.....
Mouse   225 IHCSAGCGRTGVICAVDYTWMLLKDGIIPK-NFSVFNLIQEMRTQRPSLVQTQEQYELVYSAVLE 288

  Fly  1418 YAAKITNLSNDN 1429
            ...:..::.:||
Mouse   289 LFKRHMDVISDN 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:238006	84/285 (29%)
CG42327	NP_001036706.2	Y_phosphatase	1134..1415	CDD:278528	84/285 (29%)
Ptpn22	NP_033005.1	PTPc-N22	57..290	CDD:350450	84/288 (29%)
		Substrate binding. /evidence=ECO:0000250	227..233		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..358
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..564
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..619
		Interaction with CSK. /evidence=ECO:0000269\|PubMed:8890164	613..621
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..695
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	713..802
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900