DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42327 and Ptprg

DIOPT Version :9

Sequence 1:	NP_001036706.2	Gene:	CG42327 / 41401	FlyBaseID:	FBgn0259227	Length:	1429	Species:	Drosophila melanogaster
Sequence 2:	NP_599183.2	Gene:	Ptprg / 171357	RGDID:	620774	Length:	1442	Species:	Rattus norvegicus

Alignment Length:	1124	Identity:	246/1124 - (21%)
Similarity:	389/1124 - (34%)	Gaps:	346/1124 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 HKEKNLLDWMNIAMLPLTPENRTEFVVRTTLDATEGATQATTEALVEETHSKSDITVGL------ 453
            |:::..||               .||:|..|.|:.|:....|.:|.  |...|:|...:
  Rat   227 HEKETFLD---------------PFVLRDLLPASLGSYYRYTGSLT--TPPCSEIVEWIVFRRPV 274

  Fly   454 -----------------EQDNVTTARTMPST--PDPGSMDLNMTTTTVRTQQLEVPLVKKMSDAA 499
                             :||:|.:...:.:.  |.....|..::.:.||             ||.
  Rat   275 PISYHQLEAFYSIFTTEQQDHVKSVEYLRNNFRPQQALNDRVVSKSAVR-------------DAW 326

  Fly   500 NAKLIEAVTEPQRETEAATEAATFVTLPE---KLATFGITA-RVDSTQTE------LLNVTTAAA 554
            |..|.:.:..|     ..|||:...:.|.   |:.....|| :|..:|.|      ::|...:.:
  Rat   327 NHDLADFLDNP-----LGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYS 386

  Fly   555 ATES-GEMSKANSTDTLSAMTSTTTTTARPMSVEHVTPE------------QDMEAATSLATTAA 606
            .|:: .|..|..:.|:...:.:|         :.|::|:            .||.  :..:.|..
  Rat   387 WTKNEDEKEKTFTKDSDKDLKAT---------ISHISPDSLYLFRVQAVCRNDMR--SDFSQTML 440

  Fly   607 TSSGTTEA-AATSSTTAATPVVSEAATAAEASATSEATTAATLSVATTAASTTEIAMKATQISNI 670
            ..:.||.. ..|.......|..|.|::|..|..:|.::|..:..:..:..|
  Rat   441 FQANTTRIFQGTRIVKTGVPTASPASSADMAPISSGSSTWTSSGIPFSFVS-------------- 491

  Fly   671 RDDNDDNSNDVIVATTKFPESE-QAATTASVEPTTTSVSVRVAGEVSTSIRPEIIVTSTRNSTIV 734
                        :||...|.|. ..||.|||..:|....:...|...:|.      .||...|.:
  Rat   492 ------------MATGMGPSSSGSQATVASVVTSTLLAGLGFGGGGISSF------PSTVWPTRL 538

  Fly   735 DTSTSATSVATPTQTEIAQISNEVNLEAVTVKTRDGLSDTNELRTAEKTDNAVNNSVAITESDLG 799
            .|:::|:..|........:.......:..:..|:|| ....|....||:::
  Rat   539 PTASAASKQAGRPVLATTEALASPGPDGDSAPTKDG-EGAEEGEKEEKSES-------------- 588

  Fly   800 ALATAVETNPTTTNSLLSDVSKLSKEHESSLETNNIGEAPPESTTPAAPATVAVATDESTAAPAA 864
                             .|..:..:|.|...|.....||          ...|..:|::..||..
  Rat   589 -----------------EDGEREQEEEEKDSEKKEKSEA----------THTAAESDQTAPAPTP 626

  Fly   865 TGGQEIVREGQHHDGQQVADEQDTEQQLAKTTMAVTTTTTSATTTTTSTTTTTTETPLTTTTMQP 929
            :......:||.|   |.:...:...                             ..|:|.   ||
  Rat   627 SSPHRTAQEGGH---QTIPGHRQDH-----------------------------SAPVTD---QP 656

  Fly   930 VEISL-LDDSTTTTTTTPAPPVYFESSTVASTTIR---------SSTTMLPETTTASTQSPSEMP 984
            ..:.. ||  |...|.|..||...|.....|...|         |......|.:...|.:|:|..
  Rat   657 GHVDPGLD--TLVDTATQVPPTATEEHYSGSDPKRPEMPSKKPISRGDRFSEDSKFITVNPAEKN 719

  Fly   985 PTFM--APYPNELDHMQTNAQDNGTDVNVIIAITVSVIGVVALILLVAFLYLMR--KRQKQTSYG 1045
            .:.|  .|.|..::.             :|..|.||.:..|.|:||:|.|...|  .:.|...:.
  Rat   720 TSGMISRPSPGRMEW-------------IIPLIVVSALTFVCLVLLIAVLVYWRGCNKIKSKGFP 771

  Fly  1046 QRCRPVSLDAYSLDNVSVLGSVRRKGRDMRASKRTYGNAAF---DDPSLR------------HNL 1095
            :|.|.|.             |...:|.  :.|::.:..|.|   |..|.|            .:.
  Rat   772 RRSREVP-------------SSGERGE--KGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDD 821

  Fly  1096 LTASELARFVERRSDVFE--------EFRDVPQIIARADEVP-----PGCEDKNRYANVIPLPET 1147
            :.|..:.:|.:...:::.        :|.:|.:..|..:...     |..:.||||.|::....:
  Rat   822 MEAIPVKQFGKHIGELYSNSQHGFSGDFEEVQRCTADMNITAEHSNHPDNKHKNRYINILAYDHS 886

  Fly  1148 RVVLQ-RQGDDDK-TEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDL 1210
            ||.|: ..|.|.| ::|||||||.|...| ..|||.|.||:||..|||||||||.:.:||..|:|
  Rat   887 RVKLRPLPGKDSKHSDYINANYVDGYNKA-KAYIATQGPLKSTFEDFWRMIWEQNTGIIIMITNL 950

  Fly  1211 SENGIERCAEYLPPSATLDNHSSYGDYQVTLKHREVKDRYAI------STLVLKRVDG-----EE 1264
            .|.|..:|.:|.|    .:|...||:..||||..||...|.:      :|.|.|...|     :.
  Rat   951 VEKGRRKCDQYWP----TENTEEYGNIIVTLKSTEVHACYTVRRFSVRNTKVKKGQKGNPKGRQN 1011

  Fly  1265 SRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLKSYSLEQANELREKSATLETSMDADGSKAE 1328
            .|.:..|.| :||:.|||....|::..                  :|..||.....|
  Rat  1012 ERTVIQYHYTQWPDMGVPEYALPVLTF------------------VRRSSAARMPDM-------- 1050

  Fly  1329 AGSTSSHEINGNISSRSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQLVYY 1393
                                   ||:.||||.|.|||||.|..|..::.:: .|.:|::...:.:
  Rat  1051 -----------------------GPVLVHCSAGVGRTGTYIVIDSMLQQIK-DKSTVNVLGFLKH 1091

  Fly  1394 VRRGRASAVQTKEQYEFIY 1412
            :|..|...|||:|||.||:
  Rat  1092 IRTQRNYLVQTEEQYIFIH 1110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:238006	99/293 (34%)
CG42327	NP_001036706.2	Y_phosphatase	1134..1415	CDD:278528	99/293 (34%)
Ptprg	NP_599183.2	alpha_CARP_receptor_like	67..319	CDD:239396	19/108 (18%)
		FN3	348..438	CDD:238020	17/100 (17%)
		R-PTPc-G-1	845..1118	CDD:350505	103/321 (32%)
		R-PTP-G-2	1202..1406	CDD:350508
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900