Protein Alignment MARK3 and GIN4

DIOPT Version :10

• Sequence 1: NP_001122390.2
• Gene: MARK3 / 4140
• HGNCID: 6897
• Length: 753
• Species: Homo sapiens
• Sequence 2: NP_010795.3
• Gene: GIN4 / 852119
• SGDID: S000002915
• Length: 1142
• Species: Saccharomyces cerevisiae
• Alignment Length: 736
• Identity: 204/736 - (27%)
• Similarity: 323/736 - (43%)
• Gaps: 162/736 - (22%)

Human    41 NSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN------------ 93
            |||.:..|..  ||.::|.:|:|.|:..||:|||:..||:|.|:|:|.|...|
Yeast     6 NSIPAIKDNT--IGPWKLGETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGS 68

Human    94 --PTSL-QKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEA 155
              |.:| ..:.||:.|||:|||||:::|::|.||...|||::|||..||:|:.||..|.:.|.||
Yeast    69 TTPDALPYGIEREIIIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEA 133

Human   156 RSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAA 220
            ...||||:..|.|||...|||||||.||||||...||||||||.:...|.|..|:|.||||.|||
Yeast   134 IRFFRQIIIGVSYCHALGIVHRDLKPENLLLDHKYNIKIADFGMAALETEGKLLETSCGSPHYAA 198

Human   221 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYRIPF--YMSTDCE 281
            ||:..|..|.|...||||.||||:.|::|.||||.:  |::.|..:|.:|::.:|.  .:|.:.:
Yeast   199 PEIVSGIPYQGFASDVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEFEMPSDDEISREAQ 263

Human   282 NLLKRFLVLNPIKRGTLEQIMKDRWI-------------NAGHEEDELKPFVE--PELDISDQKR 331
            :|:::.|.::|.:|.....|:|...:             ....|:..|.|..|  ..:|.:..:.
Yeast   264 DLIRKILTVDPERRIKTRDILKHPLLQKYPSIRDSKSIRGLPREDTYLTPLSESNSSIDATILQN 328

Human   332 IDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGR----------KSSELDASDSSSSSNLSLAK 386
            : :::..|...|.|:|.|.:...:.....|.||.|          |..::....|.||.::|
Yeast   329 L-VILWHGRDPEGIKEKLREPGANAEKTLYALLYRFKCDTQKELIKQQQVKKRQSISSVSVS--- 389

Human   387 VRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGIS 451
              ||..::.:..:..:.:...||:||:|:             .:::.|.:.:|.:.|:|...|.|
Yeast   390 --PSKKVSTTPQRRRNRESLISVTSSRKK-------------PISFNKFTASSASSSNLTTPGSS 439

Human   452 SRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTA 516
            .|.|.                         :...:||.||:.:.::.:.....:...|.:.....
Yeast   440 KRLSK-------------------------NFSSKKKLSTIVNQSSPTPASRNKRASVINVEKNQ 479

Human   517 DRHSVIQNGKEN----------STIPDQR-----TPVASTH------------------SISSAA 548
            .|.|:....|:|          |.||..:     |.:.||:                  :.|:.|
Yeast   480 KRASIFSTTKKNKRSSRSIKRMSLIPSMKRESVTTKLMSTYAKLAEDDDWEYIEKETKRTSSNFA 544

Human   549 T----------PDRIRFPRGTASRSTFHGQPRE----RRTATYNGPPASPSLSHEATPLSQTRSR 599
            |          .::||..:....|.....:.||    ||........|...|..|.....|...:
Yeast   545 TLIDEIFEYEKYEQIRKEKEELERKVREAKAREELERRRRKQEEKERARKLLEKEDLKRKQEELK 609

Human   600 GSTNL-FSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKP-------- 655
            ....: .|.|..:|::               .:..:.:|:.|::||..::|.|....
Yeast   610 KQIEIDISDLEQELSK---------------HKEEKLDGNIRSISAPMENEEKNINHLEVDIDNI 659

Human   656 -RSLRFTWSMKTTSSMDPGDM 675
             |...|:...:..|.:|||.|
Yeast   660 LRRRNFSLQTRPVSRLDPGIM 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36
		STKc_MARK	55..307	CDD:270974	119/270 (44%)
		UBA_MARK3_4	325..367	CDD:270590	10/51 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..600		48/276 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..655		6/22 (27%)
		MARK1-3_C	654..751	CDD:213381	7/31 (23%)
GIN4	NP_010795.3	Protein Kinases, catalytic domain	17..289	CDD:473864	120/271 (44%)
		Kcc4p_like_C	1026..1139	CDD:213379