Protein Alignment MARK3 and KIN1

DIOPT Version :10

• Sequence 1: NP_001122390.2
• Gene: MARK3 / 4140
• HGNCID: 6897
• Length: 753
• Species: Homo sapiens
• Sequence 2: NP_010407.1
• Gene: KIN1 / 851700
• SGDID: S000002529
• Length: 1064
• Species: Saccharomyces cerevisiae
• Alignment Length: 1060
• Identity: 250/1060 - (23%)
• Similarity: 402/1060 - (37%)
• Gaps: 361/1060 - (34%)

Human     5 TPL-PTVNERDTENHTSH------------GDGRQEVTSRTSRSGARCRNSIASCADEQPH---I 53
            ||| |..:.:...|..||            |..|:......:.|.:|..:|  ....:|.|   :
Yeast    55 TPLMPPADIKYANNGNSHQAEQKERQVELEGKSRENAPKPNTTSQSRVSSS--QGMPKQFHRKSL 117

Human    54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIID--------KTQLNP------------TSLQ 98
            |::..::|:|.|:..|||||:|..|....|:||::        |.|:.|            ..|:
Yeast   118 GDWEFVETVGAGSMGKVKLAKHRYTNEVCAVKIVNRATKAFLHKEQMLPPPKNEQDVLERQKKLE 182

Human    99 K-------LFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEAR 156
            |       ..||..:.:||.||:|.:|||:.......|::.||.|||::.||::.||.::|.:||
Yeast   183 KEISRDKRTIREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQHGSIREHQAR 247

Human   157 SKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAP 221
            ...|.|.||:.|.|...|||||||.||:::.....|||.|||.||.:....:|.|||||..:|||
Yeast   248 KFARGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQLHTFCGSLYFAAP 312

Human   222 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKR 286
            ||.:...|.||||||||.||:|:.||.|.:|||.:|...|.|::.:||...|.::|.:..:||.:
Yeast   313 ELLKANPYTGPEVDVWSFGVVLFVLVCGKVPFDDENSSVLHEKIKQGKVEYPQHLSIEVISLLSK 377

Human   287 FLVLNPIKRGTLEQIMKDRWINAGHEE------DELKPFVEPELDIS---DQKRIDIMVGMGYSQ 342
            .||::|.:|.||:|:::..|:..|...      .:..|.....|||:   :..|::.:
Yeast   378 MLVVDPKRRATLKQVVEHHWMVRGFNGPPPSYLPKRVPLTIEMLDINVLKEMYRLEFI------- 435

Human   343 EEIQESLSKMKYDEITATYLLLGRK------SSELDASDSSSSSNLSLAKVRPS----------- 390
            ::::|:.|.:.......||:||.|:      ....::||:.::.|::.:...|:
Yeast   436 DDVEETRSVLVSIITDPTYVLLSRQYWTLAAKMNAESSDNGNAPNITESFEDPTRAYHPMISIYY 500

Human   391 ----------SDLNNSTGQSPHHKVQR--SVSSSQKQR--------------------------- 416
                      :.:.|...:..|..:::  .:..|.|||
Yeast   501 LTSEMLDRKHAKIRNQQQRQSHENIEKLSEIPESVKQRDVEVNTTAMKSEPEATLATKDTSVPFT 565

Human   417 -RYSDHAGP----AIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNAS 476
             :.||...|    .||..:|.|:::.||.          :|||||.:.......|.:....||
Yeast   566 PKNSDGTEPPLHVLIPPRLAMPEQAHTSP----------TSRKSSDNQRREMEYALSPTPQGN-- 618

Human   477 NPNKADIPERKKSSTV--PSSNTASGGMTRRNTYVCSER--TTADRHSVIQNGKENSTIPDQRTP 537
                 |..:.:..||.  ||.....|.:.|:    .|:|  .|.::.||..|...|.       |
Yeast   619 -----DYQQFRVPSTTGDPSEKAKFGNIFRK----LSQRRKKTIEQTSVNSNNSINK-------P 667

Human   538 VASTHS------ISSAATP--------------------DRIRFPRGTASRSTFHGQPRERR--- 573
            |..|||      :...|.|                    ::..||...|.......:.||::
Yeast   668 VQKTHSRAVSDFVPGFAKPSYDSNYTMNEPVKTNDSRGGNKGDFPALPADAENMVEKQREKQIEE 732

Human   574 -------------------------TATYNG---------PPASPSLSHEATPLSQTRSRGSTNL 604
                                     ...:.|         ||.:.:...:..|.::.:|.|..
Yeast   733 DIMKLHDINKQNNEVAKGSGREAYAAQKFEGSDDDENHPLPPLNVAKGRKLHPSARAKSVGHA-- 795

Human   605 FSKLTSKLTRRNMSFRFIK-RLPT------EYERNGRYEGSSRN--------------------- 641
                      |..|.:::: .:|:      |....|..|.|..|
Yeast   796 ----------RRESLKYMRPPMPSSAYPQQELIDTGFLESSDDNKSDSLGNVTSQTNDSVSVHSV 850

Human   642 --------VSAEQKDEN--KEAK------------PRS--LRFTWSMKTTSSMDPGDMMREIRKV 682
                    |..|..||.  :||.            |||  |:..:|::||||.....:..:|..|
Yeast   851 NAHINSPSVEKELTDEEILQEASRAPAGSMPSIDFPRSLFLKGFFSVQTTSSKPLPIVRYKIMFV 915

Human   683 LDANNCDYEQ-------RERF-------------------------------------------- 696
            |...|.::::       .:||
Yeast   916 LRKMNIEFKEVKGGFVCMQRFSSNNVAAKREGTPRSIMPLSHHESIRRQGSNKYSPSSPLTTNSI 980

Human   697 -------------------LLFCVH--GDGHAENL-------VQWEMEVCKLPRLSLNGVRFKRI 733
                               .|..:|  ||| :|.:       :::|:.:.|:..:.|.||.||:|
Yeast   981 HQRKTSITETYGDDKHSGTSLENIHQQGDG-SEGMTTTEKEPIKFEIHIVKVRIVGLAGVHFKKI 1044

Human   734 SGTSIAFKNIASKIANELKL 753
            ||.:..:|.:||.|..||||
Yeast  1045 SGNTWLYKELASSILKELKL 1064

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		9/43 (21%)
		STKc_MARK	55..307	CDD:270974	109/278 (39%)
		UBA_MARK3_4	325..367	CDD:270590	9/44 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..600		58/351 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..655		10/65 (15%)
		MARK1-3_C	654..751	CDD:213381	35/189 (19%)
KIN1	NP_010407.1	STKc_Kin1_2	118..398	CDD:270979	110/279 (39%)
		MARK_C_like	890..1062	CDD:213377	32/172 (19%)