Protein Alignment MARK3 and KIN2

DIOPT Version :10

• Sequence 1: NP_001122390.2
• Gene: MARK3 / 4140
• HGNCID: 6897
• Length: 753
• Species: Homo sapiens
• Sequence 2: NP_013197.1
• Gene: KIN2 / 850785
• SGDID: S000004086
• Length: 1147
• Species: Saccharomyces cerevisiae
• Alignment Length: 1101
• Identity: 247/1101 - (22%)
• Similarity: 404/1101 - (36%)
• Gaps: 392/1101 - (35%)

Human    16 ENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGR 80
            :|..|..:|..|:.....||                 :|::..|:|:|.|:..||||.:|..|..
Yeast    76 QNDASRPNGAVELRQFHRRS-----------------LGDWEFLETVGAGSMGKVKLVKHRQTKE 123

Human    81 EVAIKIIDK-------------TQLNPTSL--------------QKLFREVRIMKILNHPNIVKL 118
            ...|||:::             :..|.:.:              ::..||..:.:||.||:|.:|
Yeast   124 ICVIKIVNRASKAYLHKQHSLPSPKNESEILERQKRLEKEIARDKRTVREASLGQILYHPHICRL 188

Human   119 FEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAEN 183
            ||:.......|::.||.|||::.||::.||.:||..||...|.|.||:||.|...|||||||.||
Yeast   189 FEMCTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEHHARKFARGIASALQYLHANNIVHRDLKIEN 253

Human   184 LLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVS 248
            :::.:...|||.|||.||.|....:|.|||||..:|||||.:.:.|.|||||:||.|::||.||.
Yeast   254 IMISSSGEIKIIDFGLSNIFDYRKQLHTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLVC 318

Human   249 GSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGH-- 311
            |.:|||.:|...|.|::.:||...|.::|.:..:||.|.:|::|::|.||:.:::..|:|.|:
Yeast   319 GKVPFDDENSSILHEKIKKGKVDYPSHLSIEVISLLTRMIVVDPLRRATLKNVVEHPWMNRGYDF 383

Human   312 -----------------EEDELKPFVEPEL--DISDQKR--IDIMVGMGYSQ--EEIQESLSKMK 353
                             :...||.....|.  ||.|.:|  |.::....|.|  :|..:.||..|
Yeast   384 KAPSYVPNRVPLTPEMIDSQVLKEMYRLEFIDDIEDTRRSLIRLVTEKEYIQLSQEYWDKLSNAK 448

Human   354 ---------YDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQ-----SPHH- 403
                     |...||...|:   .:.:.::.|.|..|      .|.|:..:.|..     |.:|
Yeast   449 GLSSSLNNNYLNSTAQQTLI---QNHITSNPSQSGYN------EPDSNFEDPTLAYHPLLSIYHL 504

Human   404 ----------KVQR------SVSSSQKQRRYSDHAG----------------------------- 423
                      |:||      ...:.|:|::.....|
Yeast   505 VSEMVARKLAKLQRRQALALQAQAQQRQQQQQVALGTKVALNNNSPDIMTKMRSPQKEVVPNPGI 569

Human   424 ---PAI---------------------PSVVAYPKR---SQTSTADSDLKEDGISSRKSSGSAVG 461
               |||                     |..:..|::   |.||...||:..:.....||:...|.
Yeast   570 FQVPAIGTSGTSNNTNTSNKPPLHVMVPPKLTIPEQAHTSPTSRKSSDIHTELNGVLKSTPVPVS 634

Human   462 GK-GIAPASPMLGNASNPN---------------------KADIPERKKSSTVPSSNTASGGMTR 504
            |: ....|||::|.....|                     :..:|||:..:.:..||..|..:.:
Yeast   635 GEYQQRSASPVVGEHQEKNTIGGIFRRISQSGQSQHPTRQQEPLPEREPPTYMSKSNEISIKVPK 699

Human   505 -------------------------------RNTYVC------SERTTADRHSVIQNGK------ 526
                                           :||.:.      |::..:|..::.||.:
Yeast   700 SHSRTISDYIPSARRYPSYVPNSVDVKQKPAKNTTIAPPIRSVSQKQNSDLPALPQNAELIVQKQ 764

Human   527 -------------------------------ENS----TIPDQRT--PVASTHSISSAATPDRIR 554
                                           :||    ::|..|.  |.|...|:..|.. :.::
Yeast   765 RQKLLQENLDKLQINDNDNNNVNAVVDGINNDNSDHYLSVPKGRKLHPSARAKSVGHARR-ESLK 828

Human   555 FPR-------------------GTASR-----------------STFHGQPRERRTATYN----- 578
            |.|                   |.|::                 :|:......|.|:.|:
Yeast   829 FTRPPIPAALPPSDMTNDNGFLGEANKERYNPVSSNFSTVPEDSTTYSNDTNNRLTSVYSQELTE 893

Human   579 ---------GPPAS-PSLSHEAT-------PLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIK--- 623
                     .||.| ||:.:..:       .:..|.|:....:...:.|.|||.|:.|:.:|
Yeast   894 KQILEEASKAPPGSMPSIDYPKSMFLKGFFSVQTTSSKPLPIVRHNIISVLTRMNIDFKEVKGGF 958

Human   624 --------------------------------------RLPTEYERNGRYEGSSRNVSAEQKDEN 650
                                                  :|.:.|....  ..:|||.|.:::...
Yeast   959 ICVQQRPSIETAAVPVITTTGVGLDSGKAMDLQNSLDSQLSSSYHSTA--SSASRNSSIKRQGSY 1021

Human   651 KEAK---PRSLRFTWSMKTTSS--MDP--GDMMREIRKVLDANNCDYEQRERFLLFC-------- 700
            |..:   |.:...|.:.:..||  |.|  |:........|.:.:.||.|::..:|..
Yeast  1022 KRGQNNIPLTPLATNTHQRNSSIPMSPNYGNQSNGTSGELSSMSLDYVQQQDDILTTSRAQNINN 1086

Human   701 VHGDGHAENL--------VQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753
            |:|.....|.        :::|:.:.|:..:.|.||.||::||.:..:|.:||.|..||.|
Yeast  1087 VNGQTEQTNTSGIKERPPIKFEIHIVKVRIVGLAGVHFKKVSGNTWLYKELASYILKELNL 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		5/19 (26%)
		STKc_MARK	55..307	CDD:270974	106/278 (38%)
		UBA_MARK3_4	325..367	CDD:270590	15/54 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..600		68/467 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..655		5/25 (20%)
		MARK1-3_C	654..751	CDD:213381	28/119 (24%)
KIN2	NP_013197.1	STKc_Kin1_2	97..377	CDD:270979	107/279 (38%)
		KA1	1104..1147	CDD:460465	15/42 (36%)