Protein Alignment MARK3 and KCC4

DIOPT Version :10

• Sequence 1: NP_001122390.2
• Gene: MARK3 / 4140
• HGNCID: 6897
• Length: 753
• Species: Homo sapiens
• Sequence 2: NP_009907.2
• Gene: KCC4 / 850334
• SGDID: S000000529
• Length: 1037
• Species: Saccharomyces cerevisiae
• Alignment Length: 709
• Identity: 206/709 - (29%)
• Similarity: 320/709 - (45%)
• Gaps: 177/709 - (24%)

Human    45 SCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN------------PTSL 97
            |.|.....||.::|.:|:|.|:..||:||:|..||...|:|:|.|:..|            |.::
Yeast    10 SAAKPSSTIGPWKLGETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNI 74

Human    98 QKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQI 162
            :   ||:.|||:|:|||::.|::|.||...||||:|||..||:|:.||.||.:.|:||.:.||||
Yeast    75 E---REIVIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQI 136

Human   163 VSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGK 227
            :..:.|||...|||||||.||||||:..||||||||.:...|....|:|.||||.|||||:..|.
Yeast   137 IIGISYCHALGIVHRDLKPENLLLDSFYNIKIADFGMAALQTDADLLETSCGSPHYAAPEIVSGL 201

Human   228 KYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYRIP--FYMSTDCENLLKRFL 288
            .|:|...||||.||||:.|::|.||||.:  |:::|..:|.:|::.:|  ..:|.|.::|:.:.|
Yeast   202 PYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPNDTEISRDAQDLIGKIL 266

Human   289 VLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMK 353
            |::|.:|..:..|:.             .|.::....|.|.|.|              :.|.:..
Yeast   267 VVDPRQRIKIRDILS-------------HPLLKKYQTIKDSKSI--------------KDLPREN 304

Human   354 YDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRY 418
                  |||.                         |.:|.||.|..|    :..|:..:.....:
Yeast   305 ------TYLY-------------------------PLADSNNHTSAS----IDDSILQNLVVLWH 334

Human   419 SDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRK--------SSGSAVGGKGIAPASPMLGNA 475
            ..||...:                |.|||:|.:..|        ....:|.|          .|.
Yeast   335 GRHADDIV----------------SKLKENGTNKEKILYALLYRFKLDSVRG----------SNK 373

Human   476 SNPNK-ADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHS-------------VIQNGK 526
            .|.|| ....:.|:|||:.||::..  :..|:......|.|:.|||             :..|..
Yeast   374 KNRNKIKKTKKNKRSSTLSSSSSLL--LNNRSIQSTPRRRTSKRHSREFSSSRKRSSFLLSSNPT 436

Human   527 ENSTIPDQRTPVASTH----SISSAATPDRIRFP--RGTASRST--FHGQPRERRTATYNGPPAS 583
            ::|.|| .|:....||    |.::.|||..:..|  |.:..||:  ....|..:|::.     .|
Yeast   437 DSSPIP-LRSSKRITHINVASANTQATPSGVPNPHKRNSKKRSSKRLSYMPNTKRSSL-----TS 495

Human   584 PSLSH--------EATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSR 640
            .|||:        :...:.:...|.|:| |:.|..::.... .|...||...|.:|..: |...:
Yeast   496 KSLSNFTNLIDDDDWEYIEKDAKRTSSN-FATLIDEIFEPE-KFELAKREKAELQRKVQ-EAKRQ 557

Human   641 NVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLD-----ANNCDYEQRE 694
            :|:|::.:|::                ...:..|.|:|::|:.|     ..|.::.|:|
Yeast   558 SVNAQKINEDE----------------FGSEVSDGMKELKKINDKVSSPLINYEFSQQE 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36
		STKc_MARK	55..307	CDD:270974	117/267 (44%)
		UBA_MARK3_4	325..367	CDD:270590	8/41 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..600		54/267 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..655		4/22 (18%)
		MARK1-3_C	654..751	CDD:213381	8/46 (17%)
KCC4	NP_009907.2	Protein Kinases, catalytic domain	19..285	CDD:473864	119/281 (42%)
		Kcc4p_like_C	920..1034	CDD:213379