Protein Alignment MARK3 and mark3b

DIOPT Version :10

• Sequence 1: NP_001122390.2
• Gene: MARK3 / 4140
• HGNCID: 6897
• Length: 753
• Species: Homo sapiens
• Sequence 2: XP_009293196.1
• Gene: mark3b / 767634
• ZFINID: ZDB-GENE-060929-80
• Length: 834
• Species: Danio rerio
• Alignment Length: 802
• Identity: 640/802 - (79%)
• Similarity: 687/802 - (85%)
• Gaps: 71/802 - (8%)

Human    18 HTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREV 82
            ||||.|||.||.||..|||||||||||||||||||||||||||||||||||||||||||||||||
Zfish    38 HTSHTDGRNEVASRPGRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREV 102

Human    83 AIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAH 147
            ||||||||||||||||||||||||||||||||||||||||||:|||||:||||||||||||||||
Zfish   103 AIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVAH 167

Human   148 GRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTF 212
            |||||||||:|||||||||||||||.|||||||||||||||||||||||||||||||:|.|||||
Zfish   168 GRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTIGNKLDTF 232

Human   213 CGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 277
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   233 CGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 297

Human   278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQ 342
            |||||||||||||||:|||||||||||||||||.||:|||||||||||||||||||||||||||:
Zfish   298 TDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGCEEEELKPFVEPELDISDQKRIDIMVGMGYSR 362

Human   343 EEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHH-KVQ 406
            |||.|||::|||||||||||||||||:||:.|||||||||||||.||:|:.||  ||||.| |||
Zfish   363 EEIHESLTRMKYDEITATYLLLGRKSTELEVSDSSSSSNLSLAKARPNSEHNN--GQSPSHLKVQ 425

Human   407 RSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDG-ISSRKSSGSAVGGKGIAPASP 470
            ::.|::||||||||.|||.||| |.|||||||::|:|:.||:| ..:||||.|  |.:|:|||||
Zfish   426 KNASTNQKQRRYSDQAGPTIPS-VGYPKRSQTTSAESEHKEEGSAQARKSSSS--GSRGMAPASP 487

Human   471 MLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENS------ 529
            |||||:||||||||:||||:..|.:|:.|.|||||||||||||...|||||||||||||
Zfish   488 MLGNANNPNKADIPDRKKSAGAPGNNSVSSGMTRRNTYVCSERNATDRHSVIQNGKENSLSEMSG 552

Human   530 ---------------------------------------TIP------------------DQRTP 537
                                                   |:|                  .||.|
Zfish   553 CVSTSPTAYAVALASSSASVRLRHQKAASLSASGHTCRATLPTSDASADLFRPNTSTAQTSQRNP 617

Human   538 VASTHSISSAATPDRIRFPRGTASRSTFH-GQPRERRTATYNGPPASPSLSHEATPLSQTRSRGS 601
            .:||||||||..|||:||||||.|||||| ||.|||||||||||||||:|||:||||||:|||||
Zfish   618 GSSTHSISSATPPDRLRFPRGTLSRSTFHGGQLRERRTATYNGPPASPTLSHDATPLSQSRSRGS 682

Human   602 TNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKT 666
            ||||:|||||||||||||||.||:|.|.:|||||:.||||||.:||:|:|:||||||||||||||
Zfish   683 TNLFTKLTSKLTRRNMSFRFSKRVPAECDRNGRYDDSSRNVSGDQKEEHKDAKPRSLRFTWSMKT 747

Human   667 TSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFK 731
            ||||:|.:||||||||||||||||||||||||.|||||||||:||||||||||||||||||||||
Zfish   748 TSSMEPTEMMREIRKVLDANNCDYEQRERFLLLCVHGDGHAESLVQWEMEVCKLPRLSLNGVRFK 812

Human   732 RISGTSIAFKNIASKIANELKL 753
            ||||||||||||||||||||||
Zfish   813 RISGTSIAFKNIASKIANELKL 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		12/17 (71%)
		STKc_MARK	55..307	CDD:270974	244/251 (97%)
		UBA_MARK3_4	325..367	CDD:270590	37/41 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..600		170/295 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..655		15/22 (68%)
		MARK1-3_C	654..751	CDD:213381	91/96 (95%)
mark3b	XP_009293196.1	STKc_MARK	75..327	CDD:270974	244/251 (97%)
		UBA_MARK3_4	345..387	CDD:270590	37/41 (90%)
		MARK1-3_C	735..832	CDD:213381	91/96 (95%)